Publications 2015

De novo transcriptome profiling of highly purified human lymphocytes primary cells.
Bonnal RJ, Ranzani V, Arrigoni A, Curti S, Panzeri I, Gruarin P, Abrignani S, Rossetti G, Pagani M.
Sci Data. 2015 Sep 29;2:150051.

Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes
Elisa Cesarini, Chiara Mozzetta, Fabrizia Marullo, Francesco Gregoretti, Annagiusi Gargiulo, Marta Columbaro, Alice Cortesi, Laura Antonelli, Simona Di Pelino, Stefano Squarzoni, Daniela Palacios, Alessio Zippo, Beatrice Bodega, Gennaro Oliva, and Chiara Lanzuolo
J Cell Biol. 2015 Oct 13;6:527. doi: 10.3389/fimmu.2015.00527. eCollection 2015. Review.

Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets.
Geginat J, Nizzoli G, Paroni M, Maglie S, Larghi P, Pascolo S, Abrignani S.
Front Immunol. 2015 Oct 13;6:527. doi: 10.3389/fimmu.2015.00527. eCollection 2015. Review.

DEPDC5 variants increase fibrosis progression in Europeans with chronic HCV infection
Burza MA, Motta BM, Mancina RM, Pingitore P, Pirazzi C, Lepore SM, Spagnuolo R, Doldo P, Russo C, Lazzaro V,Fischer J, Berg T, Aghemo A, Cheroni C, De Francesco R, Fargion S, Colombo M, Datz C, Stickel F, Valenti L, Romeo S
Hepatology. 2015 Oct 30. doi: 10.1002/hep.28322. [Epub ahead of print]

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity
Cheroni, C., Donnici, L., Aghemo, A., Balistreri, F., Bianco, A., Zanoni, V., Pagani, M., Soffredini, R., D’Ambrosio, R., Rumi, M.G., Colombo, M., Abrignani, S., Neddermann, P., De Francesco, R.
PLOS ONE , DOI:10.1371/journal.pone.0138546 September 25, 2015

eIF6 coordinates insulin sensitivity and lipid metabolism by couplingtranslation to transcription.
Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen PK, Viero G, Tebaldi T, Offenhäuser N, Rozman J, Rathkolb B, Neschen S, Klingenspor M, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Quattrone A, Falciani F, Biffo S.
Nat Commun. 2015 Sep 18;6:8261. doi: 10.1038/ncomms9261.

Two of Them Do It Better: Novel Serum Biomarkers Improve Autoimmune Hepatitis Diagnosis.
Mazzara S, Sinisi A, Cardaci A, Rossi RL, Muratori L, Abrignani S, Bombaci M.
PLoS One. 2015 Sep 16;10(9):e0137927

Transmembrane 6 superfamily member 2 gene E167K variant impacts on steatosis and liver damage in chronic hepatitis C patients.
Milano M, Aghemo A, Mancina RM, Fischer J, Dongiovanni P, De Nicola S, Fracanzani AL, D’Ambrosio R, Maggioni M, De Francesco R, Fargion S, Berg T, Stickel F, Hampe J, Romeo S, Colombo M, Valenti L
Hepatology. 2015 Jul;62(1):111-7. doi: 10.1002/hep.27811. Epub 2015 May 6.

Integration of signaling pathways with the epigenetic machinery in the maintenance of stem cells
Fagnocchi L, Mazzoleni S, Zippo A.
Hindawi Publishing Corporation Stem Cells International Article ID 679280

Signal Strength and Metabolic Requirements Control Cytokine-Induced Th17 Differentiation of Uncommitted Human T Cells
Kastirr I, Crosti MC, Maglie S, Paroni M, Steckel B, Moro M, Pagani M, Abrignani S, Geginat J
Journal of Immunology. Sept 2015

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
Zanconato F, Forcato M, Battilana G, Azzolin L, Quaranta E, Bodega B, Rosato A, Bicciato S, Cordenonsi M, Piccolo S.
Nat Cell Biol. 2015 Sep;17(9):1218-27. doi: 10.1038/ncb3216. Epub 2015 Aug 10.

Reference proteome of highly purified human Th1 cells reveals strong effects on metabolism and protein ubiquitination upon differentiation.
Pagani M, Rockstroh M, Schuster M, Rossetti G, Moro M, Crosti M, Tomm JM.
Proteomics 2015 Sep 1. doi: 10.1002/pmic.201400139. [Epub ahead of print]

eIF6 anti-association activity is required for ribosome biogenesis, translational control and tumor progression.
Brina D, Miluzio A, Ricciardi S, Biffo S.
Biochim Biophys Acta 2015 Jul;1849(7):830-5. doi: 10.1016/j.bbagrm.2014.09.010. Epub 2014 Sep 22.

IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus.
Facciotti F, Gagliani N, Häringer B, Alfen JS, Penatti A, Maglie S, Paroni M, Iseppon A, Moro M, Crosti MC, Stölzel K, Romagnani C, Moroni G,Ingegnoli F, Torretta S, Pignataro L, Annoni A, Russo F, Pagani M, Abrignani S, Meroni P, Flavell R, Geginat J.
J Allergy Clin Immunol. 2015 Aug 25. pii: S0091-6749(15)00999-9. doi: 10.1016/j.jaci.2015.06.044. [Epub ahead of print]

Normalization of circulating microRNA expression data obtained by quantitative real-time RT-PCR.
Marabita F, de Candia P, Torri A, Tegnér J, Abrignani S, Rossi RL.
Brief Bioinform. 2015 Aug 3. pii: bbv056. [Epub ahead of print]

Deregulation of MiR-34b/Sox2 Predicts Prostate Cancer Progression.
Forno I, Ferrero S, Russo MV, Gazzano G, Giangiobbe S, Montanari E, Del Nero A, Rocco B, Albo G, Languino LR, Altieri DC, Vaira V, Bosari S.
PLoS One. 2015 Jun 24;10(6):e0130060.

The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.
Di Cristofori A, Ferrero S, Bertolini I, Gaudioso G, Russo M V, Berno V, Vanini M, Locatelli M, Zavanone M, Rampini P, Vaccari T, Caroli M and Vaira V.
Oncotarget. 5. May, 22, 2015. Advanced online publication.

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
Gagliani N, Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limón P, Paiva R, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire LX, Cotton MJ, Drier Y, Bernstein B, Geginat J, Stockinger B, Esplugues E, Huber S, Flavell RA.
Nature. 2015 Jul 9;523(7559):221-5.

miRiadne: a web tool for consistent integration of miRNA nomenclature.
Bonnal R JP, Rossi RL, Carpi D, Ranzani V, Abrignani S, Pagani M.
Nucleic Acids Res. 2015 Jul 1;43(W1):W487-92.

The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.
Ranzani V, Rossetti G, Panzeri I, Arrigoni A, Bonnal RJP, Curti S, Provasi E, Sugliano E, De Francesco R, Geginat J, Bodega B, Abrignani S, Pagani M.
Nat Immunol. 2015; 16: 318-25.

Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy.
Ghosh JC, Siegelin MD, Vaira V, Faversani A, Tavecchio M, Chae YC, Lisanti S, Rampini P, Giroda M, Caino MC, Seo JH, Kossenkov AV, Michalek RD, Schultz DC, Bosari S, Languino LR, Altieri DC.
J Natl Cancer Inst. 2015; 3: 107(3).

Epigenetic alterations in cancer and personalized cancer treatment.
Miozzo M, Vaira V, Sirchia SM.
Future Oncol. 2015; 11: 333-48.

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