Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients.
Notarbartolo S, Ranzani V, Bandera A, Gruarin P, Bevilacqua V, Putignano AR, Gobbini A, Galeota E, Manara C, Bombaci M, Pesce E, Zagato E, Favalli A, Sarnicola ML, Curti S, Crosti M, Martinovic M, Fabbris T, Marini F, Donnici L, Lorenzo M, Mancino M, Ungaro R, Lombardi A, Mangioni D, Muscatello A, Aliberti S, Blasi F, De Feo T, Prati D, Manganaro L, Granucci F, Lanzavecchia A, De Francesco R, Gori A, Grifantini R, Abrignani S.
Sci Immunol. 2021 Aug 10;6(62):eabg5021.

Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies
Celikkin N, Presutti D, Maiullari F, Fornetti E, Agarwal T, Paradiso A, Volpi M, Swieszkowski W, Bearzi C, Barbetta A, Zhang YS, Gargioli C, Rizzi R and Costantini M.
Front. Bioeng. Biotechnol. 2021 Sept. 16, 9:732130. doi: 10.3389/fbioe.2021.732130

Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R
De Simone M, Chirichella M, Emming S, Mazzara S, Ranzani V, Gruarin P, Moschetti G, Pulvirenti N, Maglie S, Vasco C, Crosti MC, Rossetti G, Pagani M, Abrignani S, Monticelli S, Geginat J.
Eur J Immunol. 2021 Sep 15. doi: 10.1002/eji.202149315. Online ahead of print.

Novel interferon‑sensitive genes unveiled by correlation‑driven gene selection and systems biology
Cheroni C, Manganaro L, Donnici L, Bevilacqua V, Bonnal JP, Rossi RL, De Francesco R.
Scientific Reports, 2021. 11:18043

Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma.
Scagliola A, Miluzio A, Ventura G, Oliveto S, Cordiglieri C, Manfrini N, Cirino D, Ricciardi S, Valenti L, Baselli G, D’Ambrosio R, Maggioni M, Brina D, Bresciani A, Biffo S.
Nat Commun. 2021 Aug 12;12(1):4878.

Focus on the road to modelling cardiomyopathy in muscular dystrophy
Canonico F, Chirivi M, Maiullari F, Milan M, Rizzi R, Arcudi A, Galli M, Pane M, Gowran A, Pompilio G, Mercuri E, Crea F, Bearzi C, D’Amario D.
Cardiovascular Research, 2021 Jul 12;cvab232. doi: 10.1093/cvr/cvab232. Online ahead of print.

Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression.
Bonnal RJP, Rossetti G, Lugli E, De Simone M, Gruarin P, Brummelman J, Drufuca L, Passaro M, Bason R, Gervasoni F, Della Chiara G, D’Oria C, Martinovic M, Curti S, Ranzani V, Cordiglieri C, Alvisi G, Mazza EMC, Oliveto S, Silvestri Y, Carelli E, Mazzara S, Bosotti R, Sarnicola ML, Godano C, Bevilacqua V, Lorenzo M, Siena S, Bonoldi E, Sartore-Bianchi A, Amatu A, Veronesi G, Novellis P, Alloisio M, Giani A, Zucchini N, Opocher E, Ceretti AP, Mariani N, Biffo S, Prati D, Bardelli A, Geginat J, Lanzavecchia A, Abrignani S, Pagani M.
Nat Immunol. 2021 May 20. doi: 10.1038/s41590-021-00930-4. Online ahead of print

Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties.
Lucà R, Assenza MR, Maiullari F, Pieroni L, Maiullari S, Federici G, Marini F, Rizzi R, Urbani A, Soddu S, Moretti F.
Cell Death Dis. 2021 May 29;12(6):558. doi: 10.1038/s41419-021-03828-z.

Tumor Extracellular Matrix Stiffness Promptly Modulates the Phenotype and Gene Expression of Infiltrating T Lymphocytes
Chirivì M, Maiullari F, Milan M, Presutti D, Cordiglieri C, Crosti M, Sarnicola ML, Soluri A, Volpi M, Święszkowski W, Prati D, Rizzi M, Costantini M, Seliktar D, Parisi C, Bearzi C, Rizzi R.
Int. J. Mol. Sci.2021, 22, 5862.

Geographic differences in the incidence of Huntington’s disease in Sardinia, Italy.
Muroni A, Murru MR, Ulgheri L, Sechi M, Ercoli T, Marrosu F, Scaglione CL, Bentivoglio AR, Petracca M, Soliveri P, Cocco E, Cuccu S, Deriu M, Zuccato C, Defazio G.
Neurol Sci. 2021 Apr 1. doi: 10.1007/s10072-021-05217-y.

Huntingtin-mediated axonal transport requires arginine methylation by PRMT6.
Migazzi A, Scaramuzzino C, Anderson EN, Tripathy D, Hernández IH, Grant RA, Roccuzzo M, Tosatto L, Virlogeux A, Zuccato C, Caricasole A, Ratovitski T, Ross CA, Pandey UB, Lucas JJ, Saudou F, Pennuto M, Basso M.
Cell Rep. 2021 Apr 13;35(2):108980. doi: 10.1016/j.celrep.2021.108980.

Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells.
Marongiu L, Mingozzi F, Cigni C, Marzi R, Di Gioia M, Garrè M, Parazzoli D, Sironi L, Collini M, Sakaguchi R, Morii T, Crosti M, Moro M, Schurmans S, Catelani T, Rotem R, Colombo M, Shears S, Prosperi D, Zanoni I, Granucci F. Sci Signal. 2021 Mar 30;14(676):eaaz2120. doi: 10.1126/scisignal.aaz2120. PMID: 33785611

Development of a Specific Monoclonal Antibody to Detect Male Cells Expressing the RPS4Y1 Protein
Spena S, Cordiglieri C, Garagiola I, Peyvandi F.
Int J Mol Sci. 2021 Feb 18;22(4):2001. doi: 10.3390/ijms22042001.

SREBP2 delivery to striatal astrocytes normalizes transcription of cholesterol biosynthesis genes and ameliorates pathological features in Huntington’s disease
Birolini G, Verlengia G Talpo F, Maniezzi C, Zentilin L, Giacca M, Conforti P, Cordiglieri C, Caccia C, Leoni V.
BRAIN-2020-02219.R1

The coding and long noncoding single-cell atlas of the developing human fetal striatum.
Bocchi VD, Conforti P, Vezzoli E, Besusso D, Cappadona C, Lischetti T, Galimberti M, Ranzani V, Bonnal RJP, De Simone M, Rossetti G, He X, Kamimoto K, Espuny-Camacho I, Faedo A, Gervasoni F, Vuono R, Morris SA, Chen J, Felsenfeld D, Pavesi G, Barker RA, Pagani M, Cattaneo E.
Science. 2021 May 7;372(6542):eabf5759. doi: 10.1126/science.abf5759. PMID: 33958447.

Structure, Immunoreactivity, and In Silico Epitope Determination of SmSPI S. mansoni Serpin for Immunodiagnostic Application.
De Benedetti S, Di Pisa F, Fassi EMA, Cretich M, Musicò A, Frigerio R, Mussida A, Bombaci M, Grifantini R, Colombo G, Bolognesi M, Grande R, Zanchetta N, Gismondo MR, Mileto D, Mancon A, Gourlay LJ.
Vaccines (Basel). 2021 Apr 1;9(4):322.

Formaldehyde-mediated snapshot of nuclear architecture
Lucini F, Bianchi A, Lanzuolo C.
Methods Mol Biol. 2021, 2157:173-195

Chemotherapy triggers cachexia by deregulating synergetic function of histone-modifying enzymes
Amrute-Nayak M., Pegoli G., Holler T., Lopez-Davila A.J., Lanzuolo C. and Nayak A.
J Cachexia Sarcopenia Muscle 2021 Feb 12

Role of Cdkn2a in the Emery–Dreifuss Muscular Dystrophy Cardiac Phenotype
Pegoli G, Milan M, Manti PG, Bianchi A, Lucini F, Santarelli P, Bearzi C, Rizzi R, Lanzuolo C.
Biomolecules. 2021 Apr 6;11(4):538. doi: 10.3390/biom11040538. PMID: 33917623

hiPSCs for predictive modelling of neurodegenerative diseases: dreaming the possible
Rivetti di Val Cervo P, Besusso D, Conforti P & Cattaneo E.
Nature Reviews Neurology. 2021 Mar 3:1–12. doi: 10.1038/s41582-021-00465-0. Epub ahead of print. PMID: 33658662; PMCID: PMC7928200.

ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington’s disease
Cozzolino F, Vezzoli E, Cheroni C, Besusso D, Conforti P, Valenza M, Iacobucci I, Monaco V, Birolini, Bombaci M, Falqui A, Saftig P, Rossi R, Monti M, Cattaneo E, Zuccato C.
Hum Mol Genet. 2021 Feb 18;ddab047.

In vivo organized neovascularization induced by 3D bioprinted endothelial-derived extracellular vesicles
Maiullari F, Chirivì M, Costantini M, Ferretti AM, Recchia S, Maiullari S, Milan M, Presutti D, Pace V, Raspa M, Scavizzi F, Massetti M, Petrella L, Fanelli M, Rizzi M, Fortunato O, Moretti F, Caradonna E, Bearzi C, Rizzi R.
Biofabrication. 2021 Jan 12. doi: 10.1088/1758-5090/abdacf.

Early maternal care restores LINE-1 methylation and enhances neurodevelopment in preterm infants
Fontana C, Marasca F, Provitera L, Mancinelli S, Pesenti N, Sinha S, Passera S, Abrignani S, Mosca F, Lodato S, Bodega B, Fumagalli M.
BMC Med. 2021 Feb 5;19(1):42.

Modeling autism-associated SHANK3 deficiency using human cortico-striatal organoids generated from single neural rosettes
Wang Y, Chiola S, Yang G, Russell C, Armstrong C J, Wu Y, Spampanato J, Tarboton P, Chang A N, Harmin D A, Vezzoli E, Besusso D, Cui J, Cattaneo E, Kubanek J, Shcheglovitov A.
bioRxiv preprint, version posted January 25, 2021, doi:https://doi.org/ 10.1101/2021.01.25.428022

Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington’s disease
Birolini G, Valenza M, Ottonelli I, Passoni A, Favagrossa M, Duskey JT, Bombaci M, Vandelli MA, Colombo L, Bagnati R, Caccia C, Leoni V, Taroni F, Forni F, Ruozi B, Salmona M, Tosi G, Cattaneo E.
J Control Release. 2021 Jan 5;330:587-598.

INGM RESEARCH IS SUPPORTED BY