RUES2 hESCs exhibit MGE-biased neuronal differentiation and muHTT-dependent defective specification hinting at SP1
Conforti P, Besusso D, Brocchetti S, Campus I, Cappadona C, Galimberti M, Laporta A, Iennaco R, Rossi RL, Bocchi Dickinson V, Cattaneo E.
Neurobiology of Disease, Oct. 2020, doi.org/10.1016/j.nbd.2020.105140. In press.

FAM46C and FNDC3A are multiple myeloma tumor suppressors that act in concert to impair clearing of protein aggregates and autophagy
Manfrini N, Mancino M, Miluzio A, Oliveto S, Balestra M, Calamita P, Alfieri R, Rossi RL, Sassoè-Pognetto M, Salio C, Cuomo A, Bonaldi T, Manfredi M, Marengo E, Ranzato E, Martinotti S, Cittaro D, Tonon G, Biffo S.
Cancer Res. 2020 Sep 22;canres.1357.2020.

GADD34 is a modulator of autophagy during starvation
Gambardella G, Staiano L, Moretti MN, De Cegli R, Fagnocchi L, Di Tullio G, Polletti S, Braccia C, Armirotti A, Zippo A, Ballabio A, De Matteis MA, Di Bernardo D.
Sci Adv. 2020 Sep 25;6(39)

Frataxin gene editing rescues Friedreich’s ataxia pathology in dorsal root ganglia organoid-derived sensory neurons
Mazzara PG, Muggeo S, Luoni M, Massimino L, Zaghi M, Tajalli-Tehrani Valverde P, Brusco S, Marzi MJ, Palma C, Colasante G, Iannielli A, Paulis M, Cordiglieri C, Giannelli SG, Podini P, Gellera C, Taroni F, Nicassio F, Rasponi M, Broccoli V
Nat Commun. 2020 Aug 21;11(1):4178. doi:10.1038/s41467-020-17954-3

Single Myofiber Isolation and Culture from a Murine Model of Emery-Dreifuss Muscular Dystrophy in Early Post-Natal Development
Pegoli G, Lucini F, Mozzetta C and Lanzuolo C
JoVE. 2020; Published July 1, 2020

Nanoparticle‐Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment
Salvioni L, Zuppone S, Andreata F, Monieri M, Mazzucchelli S, Di Carlo C, Morelli L, Cordiglieri C, Donnici L,
De Francesco R, Corsi F, Prosperi D, Vago R, and Colombo M
Adv. Therap.  2000007

Extracellular Vesicles From Skeletal Muscle Cells Efficiently Promote Myogenesis in Induced Pluripotent Stem Cells
Baci D, Chirivì M, Pace V, Maiullari F, Milan M, Rampin A, Somma P, Presutti D, Garavelli S, Bruno A, Cannata S, Lanzuolo C, Gargioli C, Rizzi R, Bearzi C.
Cells, 2020 Jun 23: E1527

Intermittent β-adrenergic blockade downregulates the gene expression of β-myosin heavy chain in the mouse heart
Maccari S, Pace V, Barbagallo F, Stati T, Ambrosio C, Grò MC, Molinari P, Vezzi V, Catalano L, Matarrese P, Patrizio M, Rizzi R, Marano G.
Eur J Pharmacol.  Available on line 2020 Jun 22:173287. doi:10.1016/j.ejphar.2020.173287. In press.

Type III interferons disrupt the lung epithelial barrier upon viral recognition
Broggi A, Ghosh S, Sposito B, Spreafico R, Balzarini F, Lo Cascio A, Clementi N, De Santis M, Mancini N, Granucci F, Zanoni I.
Science. 2020 Jun 11:eabc3545. doi: 10.1126/science.abc3545

Profound Alterations of the Chromatin Architecture at Chromosome 11p15.5 in Cells From Beckwith-Wiedemann and Silver-Russell Syndromes Patients
Rovina D, La Vecchia M, Cortesi A, Fontana L, Pesant M, Maitz S, Tabano S, Bodega B, Miozzo M, Sirchia S
Sci Rep. 2020 May 19;10(1):8275.

IRF4 Instructs Effector Treg Differentiation and Immune Suppression in Human Cancer
Alvisi G, Brummelman J, Puccio S, Mazza E Mc, Paoluzzi Tomada E, Losurdo A, Zanon V, Peano C, Colombo F S, Scarpa A, Alloisio M, Vasanthakumar A, Roychoudhuri R, Kallikourdis M, Pagani M, Lopci E, Novellis P, Blume J, Kallies A, Veronesi G, Lugli E.
J Clin Invest. 2020 May 11;130426. Online ahead of print.

The Sophisticated Transcriptional Response Governed by Transposable Elements in Human Health and Disease
Marasca F, Gasparotto E, Polimeni B, Vadalà R , Ranzani V, Bodega B.
Int J Mol Sci. 2020 Apr 30;21(9):E3201.

OligoMinerApp: A Web-Server Application for the Design of Genome-Scale Oligonucleotide in Situ Hybridization Probes Through the Flexible OligoMiner Environment
Passaro M, Martinovic M, Bevilacqua V, Hershberg E A, Rossetti G, Beliveau B, Bonnal RJP, Pagani M.
Nucleic Acids Res. 2020 Apr 20;gkaa251. Online ahead of print.

Dysfunctional polycomb transcriptional repression contributes to Lamin A/C dependent muscular dystrophy
Bianchi A, Mozzetta C, Pegoli G, Lucini F, Valsoni S, Rosti V, Petrini C, Cortesi A, Gregoretti F, Antonelli L, Oliva G, De Bardi M, Rizzi R, Bodega B, Pasini D, Ferrari F, Bearzi C, Lanzuolo C
J Clin Invest. 2020; May 2020; 130(5):2408-2421.

Ribosome profiling unveils translational regulation of metabolic enzymes in primary CD4+ Th1 cells
Manfrini N, Ricciardi S, Alfieri R, Ventura G, Calamita P, Favalli A, Biffo S.
Dev Comp Immunol. 2020 Aug;109:103697. Epub 2020 Apr 21

The Endless Frontier? The Recent Increase of R&D Productivity in Pharmaceuticals
Pammolli F, Righetto L, Abrignani S, Pani L, Pelicci PG, Rabosio E.
J Transl Med, 2020 Apr 9;18(1):162.doi:10.1186/s1296-020-02313-z.

DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis
Thiruvalluvan A, de Mattos EP, Brunsting JF, Bakels R, Serlidaki D, Barazzuol L, Conforti P, Fatima A, Koyuncu S, Cattaneo E, Vilchez D, Bergink S, Boddeke E H W G, Copray S, Kampinga HH.
Mol Cell, 2020 Mar 25;S1097-2765(20)30115-5. doi:10.1016/j.molcel.2020.02.022. Online ahead of print.

Evidence for a pathogenic role of extrafollicular, IL-10–producing CCR6+B helper T cells in systemic lupus erythematosus
Facciotti F, Larghi P, Bosotti R, Vasco C, Gagliani N, Cordiglieri C, Mazzara S, Ranzani V, Rottoli E, Curti S, Penatti A, Karnani B, Kobayashi Y, Crosti M, Bombaci M, van Hamburg JP, Rossetti G, Gualtierotti R, Gerosa M, Gatti S, Torretta S, Pignataro L, Tas SW, Abrignani S, Pagani M, Grassi F, Meroni PL, Flavell RA, and Geginat J.
PNAS , March 17,2020; http://doi. org/10.1073/pnas.1917834117.

Immunological variables associated with clinical and endoscopic response to vedolizumab in patients with inflammatory bowel diseases.
Coletta M, Paroni M, Alvisi MF, De Luca M, Rulli E, Mazza S, Facciotti F, Lattanzi G, Strati F, Abrignani S, Fantini MC, Vecchi M, Geginat J, Caprioli F.
J Crohns Colitis. 2020 Feb 26. pii: jjaa035. doi: 10.1093/ecco-jcc/jjaa035. [Epub ahead of print]

High-dose vitamin C enhances cancer immunotherapy.
Magrì A, Germano G, Lorenzato A, Lamba S, Chilà R, Montone M, Amodio V, Ceruti T, Sassi F, Arena S, Abrignani S, D’Incalci M, Zucchetti M, Di Nicolantonio F, Bardelli A.
Sci Transl Med. 2020 Feb 26;12(532). pii: eaay8707. doi: 10.1126/scitranslmed.aay8707.

Cellular and molecular mechanisms of antifungal innate immunity at epithelial barriers: The role of C-type lectin receptors
Borriello F, Zanoni I, Granucci F.
Eur J Immunol. 2020 Mar; 50 (3):317-325. Epub 2020 Feb 6.

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells 
Marasca F, Cortesi A, Manganaro L, Bodega B.
J Vis Exp 2020 Jan 25;(155)

Tumor-Educated Platelets and Angiogenesis in Glioblastoma: Another Brick in the Wall for Novel Prognostic and Targetable Biomarkers, Changing the Vision from a Localized Tumor to a Systemic Pathology
Campanella R, Guarnaccia L, Cordiglieri C, Trombetta E, Caroli M, Carrabba G, La Verde N, Rampini P, Gaudino C, Costa A, Luzzi S, Mantovani G, Locatelli M, Riboni L, Navone SE and Marfia G.
Cells 2020, 9, 294; doi:10.3390/cells9020294. Published: 25 January 2020

Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits
Pesce E, Miluzio A, Turcano L, Minici C, Cirino D, Calamita P, Manfrini N, Oliveto S, Ricciardi S, Grifantini R, Degano M, Bresciani A, Biffo S.
Cells. 2020 Jan 10; 9(1):172.

A Structurally Simple Vaccine Candidate Reduces Progression and Dissemination of Triple-Negative Breast Cancer
Amedei A, Asadzadeh F, Papi F, Vannucchi MG, Ferrucci V, Bermejo I A, Fragai M, Vieira De Almeida C, Cerofolini L, Giuntini S, Bombaci M, Pesce E, Niccolai E, Natali F, Guarini E, Gabel F, Traini C, Catarinicchia S, Ricci F, Orzalesi L, Berti F, Corzana F, Zollo M, Grifantini R and Nativi C.
iScience. 2020 Jun 26; 23(6): 101250. Published online 2020 Jun 6

Efficacy of Cholesterol Nose-to-Brain Delivery for Brain Targeting in Huntington’s Disease.
Passoni A, Favagrossa M, Colombo L, Bagnati R, Gobbi M, Diomede L, Birolini G, Di Paolo E, Valenza M, Cattaneo E, Salmona M.
ACS Chem Neurosci. 2020 Feb 5;11(3):367-372. doi: 10.1021/acschemneuro.9b00581. Epub 2020 Jan 7

Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion
Broggi A, Granucci F, Zanoni I.
J Exp Med. 2020 Jan 6; 217(1):e20190295.

The induction and function of the anti-inflammatory fate of T H 17 cells
Xu H, Agalioti T, Zhao J, Steglich , Wahib R, Amezcua Vesely MC, Bielecki P, Bailis W, Jackson R, Perez D, Izbicki J, Licona-Limón P, Kaartinen V, Geginat J, Esplugues E, Tolosa E, Huber S, Flavell R, Gagliani N.
Nat Commun. 2020 Jul 3;11(1):3334.

Huntingtin gene CAG repeat size affects autism risk: Family-based and case-control association study.
Piras IS, Picinelli C, Iennaco R, Baccarin M, Castronovo P, Tomaiuolo P, Cucinotta F, Ricciardello A, Turriziani L, Nanetti L, Mariotti C, Gellera C, Lintas C, Sacco R, Zuccato C, Cattaneo E, Persico AM.
Am J Med Genet B Neuropsychiatr Genet. 2020 Sep;183(6):341-351.

Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease.
Besusso D, Schellino R, Boido M, Belloli S, Parolisi R, Conforti P, Faedo A, Cernigoj M, Campus I, Laporta A, Bocchi VD, Murtaj V, Parmar M, Spaiardi P, Talpo F, Maniezzi C, Toselli MG, Biella G, Moresco RM, Vercelli A, Buffo A, Cattaneo E.
Stem Cell Reports. 2020 May 12;14(5):876-891.

Inflammatory interactions between degenerated intervertebral discs and microglia: Implication of sphingosine-1-phosphate signaling
Navone S, Campanella R, Guarnaccia L, Ouellet JA, Locatelli M, Cordiglieri C, Gualtierotti R, Gaudino C, Ciniglio Appiani G, Luzzi S, Borsa S, Rampini P, Pluderi M, Haglund L, Riboni L, Alini M, Marfia G.
J Orthop Res. 2020 Aug 11. doi: 10.1002/jor.24827.

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