A 12-month follow-up of the immune response to SARS-CoV-2 primary vaccination: evidence from a real-world study.
Fedele G, Schiavoni I, Trentini F, Leone P, Olivetta E, Fallucca A, Fiore S, Di Martino A, Abrignani S, Baldo V, Baldovin T, Bandera A, Clerici P, De Paschale M, Diaco F, Domnich A, Fortunato F, Giberti I, Gori A, Grifantini R, Lazzarotto T, Lodi V, Mastroianni CM, Prato R, Restivo V, Vitale F, Brusaferro S, Merler S, Palamara AT, Stefanelli P; Study Group for the Immunological Monitoring post Covid19 vaccination.
Front Immunol. 2023 Nov 20;14:1272119.

Inhibition of the lysine demethylase LSD1 modulates the balance between inflammatory and antiviral responses against coronaviruses.
Mazzarella L, Santoro F, Ravasio R, Fumagalli V, Massa PE, Rodighiero S, Gavilán E, Romanenghi M, Duso BA, Bonetti E, Manganaro L, Pallavi R, Trastulli D, Pallavicini I, Gentile C, Monzani S, Leonardi T, Pasqualato S, Buttinelli G, Di Martino A, Fedele G, Schiavoni I, Stefanelli P, Meroni G, de Francesco R, Steinkuhler C, Fossati G, Iannacone M, Minucci S, Pelicci PG.
Sci Signal. 2023 Dec 19;16(816):eade0326.

Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance.
Amodio V, Lamba S, Chilà R, Cattaneo CM, Mussolin B, Corti G, Rospo G, Berrino E, Tripodo C, Pisati F, Bartolini A, Aquilano MC, Marsoni S, Mauri G, Marchiò C, Abrignani S, Di Nicolantonio F, Germano G, Bardelli A.
Cancer Cell. 2023 Jan 9;41(1):196-209.e5.

Regulatory T-cell-derived interleukin-15 shapes cytotoxic T cell memory.
Geginat J, Granucci F.
Eur J Immunol. 2023 Jan;53(1):e2250238.

Plasma Proteomic Variables Related to COVID-19 Severity: An Untargeted nLC-MS/MS Investigation
Pagani L, Chinello C, Risca G, Capitoli G, Criscuolo L, Lombardi A, Ungaro R, Mangioni D, Piga I, Muscatello A, Blasi F, Favalli A, Martinovic M, Gori A, Bandera A, Grifantini R, Magni F.
Int. J. Mol. Sci. 2023, 24, 3570.

Eomesodermin-expressing type 1 regulatory (EOMES+ Tr1)-like T cells: Basic biology and role in immune-mediated diseases.
Geginat J, Vasco C, Gruarin P, Bonnal R, Rossetti G, Silvestri Y, Carelli E, Pulvirenti N, Scantamburlo M, Moschetti G, Clemente F, Grassi F, Monticelli S, Pagani M, Abrignani S.
Eur J Immunol. 2023 May;53(5):e2149775.

Nirmatrelvir treatment of SARS-CoV-2-infected mice blunts antiviral adaptive immune responses.
Fumagalli V, Di Lucia P, Ravà M, Marotta D, Bono E, Grassi S, Donnici L, Cannalire R, Stefanelli I, Ferraro A, Esposito F, Pariani E, Inverso D, Montesano C, Delbue S, Perlman S, Tramontano E, De Francesco R, Summa V, Guidotti LG, Iannacone M.
EMBO Mol Med. 2023 Mar 22:e17580.

Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity.
Unali G, Crivicich G, Pagani I, Abou-Alezz M, Folchini F, Valeri E, Matafora V, Reisz JA, Giordano AMS, Cuccovillo I, Butta GM, Donnici L, D’Alessandro A, De Francesco R, Manganaro L, Cittaro D, Merelli I, Petrillo C, Bachi A, Vicenzi E, Kajaste-Rudnitski A. I
EMBO J. 2023 Mar 27:e112234.

Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2.
Miluzio A, Cuomo A, Cordiglieri C, Donnici L, Pesce E, Bombaci M, Conti M, Fasciani A, Terracciano L, Manganaro L, Toccafondi M, Scagliola A, Oliveto S, Ricciardi S, Grifantini R, De Francesco R, Abrignani S, Manfrini N, Biffo S.
EBioMedicine. 2023 Jan;87:104390.

Translational Control of Metabolism and Cell Cycle Progression in Hepatocellular Carcinoma.
Scagliola A, Miluzio A, Biffo S.
Int J Mol Sci. 2023 Mar 3;24(5):4885.

B cell analyses after SARS-CoV-2 mRNA third vaccination reveals a hybrid immunity like antibody response.
Andreano E, Paciello I, Pierleoni G, Piccini G, Abbiento V, Antonelli G, Pileri P, Manganaro N, Pantano E, Maccari G, Marchese S, Donnici L, Benincasa L, Giglioli G, Leonardi M, De Santi C, Fabbiani M, Rancan I, Tumbarello M, Montagnani F, Sala C, Medini D, De Francesco R, Montomoli E, Rappuoli R.
Nat Commun. 2023 Jan 4;14(1):53.

Targeting Siderophore-Mediated Iron Uptake in M. abscessus: A New Strategy to Limit the Virulence of Non-Tuberculous Mycobacteria.
Mori M, Stelitano G, Cazzaniga G, Gelain A, Tresoldi A, Cocorullo M, Roversi M, Chiarelli LR, Tomaiuolo M, Delre P, Mangiatordi GF, Griego A, Rizzello L, Cassetta A, Covaceuszach S, Villa S, Meneghetti F.
Pharmaceutics. 2023 Feb 2;15(2):502.

SARS-COV-2 specific t-cells in patients with thyroid disorders related to COVID-19 are enriched in the thyroid and acquire a tissue-resident memory phenotype
Silvestri Y, Clemente F, Moschetti G, Maioli S, Carelli E, Espadas de Arias Al, Torelli R, Longhi E, De Feo T, Crosti MC, Sarnicola ML, Salvi M, Mantovani G, Arosio M, Bombaci M, Pesce E, Grifantini R, Abrignani S, Geginat J, Muller I.
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An intestinal Th17 subset is associated with inflammation in Crohn’s Disease and activated by adherent-invasive Escherichia coli (AIEC).
Paroni M, Leccese G, Ranzani V, Moschetti G, Chiara M, Perillo F, Ferri S, Clemente F, Noviello D, Conforti FS, Ferrero S, Karnani B, Bosotti R, Vasco C, Curti S, Crosti MC, Gruarin P, Rossetti G, Conte MP, Vecchi M, Pagani M, Landini P, Facciotti F, Abrignani S, Caprioli F, Geginat J.
J Crohns Colitis. 2023 Jul 18:jjad119.

TMEM123 a key player in immune surveillance of colorectal cancer.
Pesce E, Cordiglieri C, Bombaci M, Eppenberger-Castori S, Oliveto S, Manara C, Crosti M, Ercan C, Coto M, Gobbini A, Campagnoli S, Donnarumma T, Martinelli M, Bevilacqua V, De Camilli E, Gruarin P, Sarnicola ML, Cassinotti E, Baldari L, Viale G, Biffo S, Abrignani S, Terracciano LM, Grifantini R.
Front Immunol. 2023 Jun 23;14:1194087. doi: 10.3389/fimmu.2023.1194087. PMID: 37426665; PMCID: PMC10327427.

Clonal composition and persistence of antigen-specific circulating T follicular helper cells.
Hu M, Notarbartolo S, Foglierini M, Jovic S, Mele F, Jarrossay D, Lanzavecchia A, Cassotta A, Sallusto F.
Eur J Immunol. 2023 Feb;53(2):e2250190.

Serine metabolism during differentiation of human iPSC-derived astrocytes.
Tripodi F, Motta Z, Murtas G, Rabattoni V, Nonnis S, Grassi Scalvini F, Rinaldi AM, Rizzi R, Bearzi C, Badone B, Sacchi S, Tedeschi G, Maffioli E, Coccetti P, Pollegioni L.
FEBS J. 2023 Sep;290(18):4440-4464.

Combining rotary wet-spinning biofabrication and electro-mechanical stimulation for thein vitroproduction of functional myo-substitutes.
Celikkin N, Presutti D, Maiullari F, Volpi M, Promovych Y, Gizynski K, Dolinska J, Wiśniewska A, Opałło M, Paradiso A, Rinoldi C, Fuoco C, Swieszkowski W, Bearzi C, Rizzi R, Gargioli C, Costantini M.
Biofabrication. 2023 Aug 9;15(4).

The Protein Network in Subcutaneous Fat Biopsies from Patients with AL Amyloidosis: More Than Diagnosis?
Di Silvestre D, Brambilla F, Lavatelli F, Chirivì M, Canetti D, Bearzi C, Rizzi R, Bijzet J, Hazenberg BPC, Bellotti V, Gillmore JD, Mauri P.
Cells. 2023 Feb 22;12(5):699.

Revealing the amyloid β-protein with zinc finger protein of micronucleus during Alzheimer’s disease progress by a quaternary ammonium terpyridine probe.
Ding H, Liu S, Du W, Su L, Chen J, Tian Y, Pan D, Chen L, Rizzello L, Zheng X, Battaglia G, Luo K, Gong Q, Tian X.
Biosens Bioelectron. 2023 Sep 15;236:115446.

Generation of human cerebral organoids with a structured outer subventricular zone.
Walsh R, Giacomelli E, Ciceri G, Rittenhouse C, Galimberti M, Wu Y, Muller J, Vezzoli E, Jungverdorben J, Zhou T, Barker RA, Cattaneo E, Studer L, Baggiolini A.
bioRxiv [Preprint]. 2023 Feb 17:2023.02.17.528906.

The translational potential of cholesterol-based therapies for neurological disease.
Valenza M, Birolini G, Cattaneo E.
Nat Rev Neurol. 2023 Oct;19(10):583-598.

Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington’s disease.
Birolini G, Valenza M, Ottonelli I, Talpo F, Minoli L, Cappelleri A, Bombaci M, Caccia C, Canevari C, Trucco A, Leoni V, Passoni A, Favagrossa M, Nucera MR, Colombo L, Paltrinieri S, Bagnati R, Duskey JT, Caraffi R, Vandelli MA, Taroni F, Salmona M, Scanziani E, Biella G, Ruozi B, Tosi G, Cattaneo E.
Pharmacol Res. 2023 Aug;194:106823.

Microcephaly-associated protein WDR62 shuttles from the Golgi apparatus to the spindle poles in human neural progenitors.
Dell’Amico C, Angulo Salavarria MM, Takeo Y, Saotome I, Dell’Anno MT, Galimberti M, Pellegrino E, Cattaneo E, Louvi A, Onorati M.
Elife. 2023 Jun 5;12:e81716.

hESC-derived striatal progenitors grafted into a Huntington’s disease rat model support long-term functional motor recovery by differentiating, self-organizing and connecting into the lesioned striatum.
Schellino R, Besusso D, Parolisi R, Gómez-González GB, Dallere S, Scaramuzza L, Ribodino M, Campus I, Conforti P, Parmar M, Boido M, Cattaneo E, Buffo A.
Stem Cell Res Ther. 2023 Jul 28;14(1):189.

Cellular Targets of HIV-1 Protease: Just the Tip of the Iceberg?
Centazzo M, Manganaro L, Alvisi G.
Viruses. 2023 Mar 9;15(3):712.

Leveraging tissue-specific enhancer-target gene regulatory networks identifies enhancer somatic mutations that functionally impact lung cancer.
Hariprakash JM, Salviato E, La Mastra F, Sebestyén E, Tagliaferri I, Silva RS, Lucini F, Farina L, Cinquanta M, Rancati I, Riboni M, Minardi SP, Roz L, Gorini F, Lanzuolo C, Casola S, Ferrari F.
Cancer Res. 2023 Oct 19.

Tissue fluidification promotes a cGAS-STING cytosolic DNA response in invasive breast cancer.
Frittoli E, Palamidessi A, Iannelli F, Zanardi F, Villa S, Barzaghi L, Abdo H, Cancila V, Beznoussenko GV, Della Chiara G, Pagani M, Malinverno C, Bhattacharya D, Pisati F, Yu W, Galimberti V, Bonizzi G, Martini E, Mironov AA, Gioia U, Ascione F, Li Q, Havas K, Magni S, Lavagnino Z, Pennacchio FA, Maiuri P, Caponi S, Mattarelli M, Martino S, d’Adda di Fagagna F, Rossi C, Lucioni M, Tancredi R, Pedrazzoli P, Vecchione A, Petrini C, Ferrari F, Lanzuolo C, Bertalot G, Nader G, Foiani M, Piel M, Cerbino R, Giavazzi F, Tripodo C, Scita G.
Nat Mater. 2023 May;22(5):644-655.

Polycomb Bodies Detection in Murine Fibromuscular Stroma from Skin, Skeletal Muscles, and Aortic Tissues.
Rosti V, Gorini F, Santarelli P, Sarnicola ML, Magnani S, Lanzuolo C.
Methods Mol Biol. 2023;2655:125-146.

Segmentation, 3D Reconstruction, and Analysis of PcG Proteins in Fluorescence Microscopy Images in Different Cell Culture Conditions.
Gregoretti F, Lucini F, Cesarini E, Oliva G, Lanzuolo C, Antonelli L.
Methods Mol Biol. 2023;2655:147-169.

FAM46C Is an Interferon-Stimulated Gene That Inhibits Lentiviral Particle Production by Modulating Autophagy.
Mancino M, Lai G, De Grossi F, Cuomo A, Manganaro L, Butta GM, Ferrari I, Vicenzi E, Poli G, Pesce E, Oliveto S, Biffo S, Manfrini N.
Microbiol Spectr. 2023 Aug 17;11(4):e0521122.

Human T lymphocytes at tumor sites.
Notarbartolo S, Abrignani S.
Semin Immunopathol. 2022 Nov;44(6):883-901.

Green Silver Nanoparticles Promote Inflammation Shutdown in Human Leukemic Monocytes.
Cascione M, Rizzello L, Manno D, Serra A, De Matteis V.
Materials (Basel). 2022 Jan 20;15(3):775.

Omicron BA.1 and BA.2 neutralizing activity elicited by a comprehensive panel of human vaccines.
Bowen JE, Sprouse KR, Walls AC, Mazzitelli IG, Logue JK, Franko NM, Ahmed K, Shariq A, Cameroni E, Gori A, Bandera A, Posavad CM, Dan JM, Zhang Z, Weiskopf D, Sette A, Crotty S, Iqbal NT, Corti D, Geffner J, Grifantini R, Chu HY, Veesler D.
bioRxiv [Preprint]. 2022 Mar 16:2022.03.15.484542.

Human airway organoids and microplastic fibers: A new exposure model for emerging contaminants.
Winkler AS, Cherubini A, Rusconi F, Santo N, Madaschi L, Pistoni C, Moschetti G, Sarnicola ML, Crosti M, Rosso L, Tremolada P, Lazzari L, Bacchetta R.
Environ Int. 2022 May;163:107200.

Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis.
Oberkersch RE, Pontarin G, Astone M, Spizzotin M, Arslanbaeva L, Tosi G, Panieri E, Ricciardi S, Allega MF, Brossa A, Grumati P, Bussolati B, Biffo S, Tardito S, Santoro MM.
Dev Cell. 2022 May 23;57(10):1241-1256.e8.

Hybrid Polyelectrolyte Nanocomplexes for Non-Viral Gene Delivery with Favorable Efficacy and Safety Profile.
Maiorano G, Guido C, Russo A, Giglio A, Rizzello L, Testini M, Cortese B, D’Amone S, Gigli G, Palamà IE.
Pharmaceutics. 2022 Jun 21;14(7):1310.

Human platelet lysate-derived extracellular vesicles enhance angiogenesis through miR-126.
Bordin A, Chirivì M, Pagano F, Milan M, Iuliano M, Scaccia E, Fortunato O, Mangino G, Dhori X, De Marinis E, D’Amico A, Miglietta S, Picchio V, Rizzi R, Romeo G, Pulcinelli F, Chimenti I, Frati G, De Falco E.
Cell Prolif. 2022 Nov;55(11):e13312.

Synthesis and Assessment of the In Vitro and Ex Vivo Activity of Salicylate Synthase (Mbti) Inhibitors as New Candidates for the Treatment of Mycobacterial Infections.
Mori M, Stelitano G, Griego A, Chiarelli LR, Cazzaniga G, Gelain A, Pini E, Camera M, Canzano P, Fumagalli A, Scarpa E, Cordiglieri C, Rizzello L, Villa S, Meneghetti F.
Pharmaceuticals (Basel). 2022 Aug 11;15(8):992.

Caffeic Acid-Grafted PLGA as a Novel Material for the Design of Fluvastatin-Eluting Nanoparticles for the Prevention of Neointimal Hyperplasia.
Bellosta S, Selmin F, Magri G, Castiglioni S, Procacci P, Sartori P, Scarpa E, Tolva V, Rossi C, Puoci F, Rizzello L, Cilurzo F.
Mol Pharm. 2022 Nov 7;19(11):4333-4344.

Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study.
Scagliola A, Miluzio A, Mori G, Ricciardi S, Oliveto S, Manfrini N, Biffo S.
Int J Mol Sci. 2022 Jul 13;23(14):7720.

Brain Regional Identity and Cell Type Specificity Landscape of Human Cortical Organoid Models.
Magni M, Bossi B, Conforti P, Galimberti M, Dezi F, Lischetti T, He X, Barker RA, Zuccato C, Espuny-Camacho I, Cattaneo E.
Int J Mol Sci. 2022 Oct 29;23(21):13159.

SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines.
Bowen JE, Park YJ, Stewart C, Brown JT, Sharkey WK, Walls AC, Joshi A, Sprouse KR, McCallum M, Tortorici MA, Franko NM, Logue JK, Mazzitelli IG, Nguyen AW, Silva RP, Huang Y, Low JS, Jerak J, Tiles SW, Ahmed K, Shariq A, Dan JM, Zhang Z, Weiskopf D, Sette A, Snell G, Posavad CM, Iqbal NT, Geffner J, Bandera A, Gori A, Sallusto F, Maynard JA, Crotty S, Van Voorhis WC, Simmerling C, Grifantini R, Chu HY, Corti D, Veesler D.
Sci Immunol. 2022 Dec 23;7(78):eadf1421.

Biomimetic Keratin-Coated Gold Nanoparticles for Photo-Thermal Therapy in a 3D Bioprinted Glioblastoma Tumor Model.
Chirivì M, Bearzi C, Rosa P, Miglietta S, Petronella F, De Falco E, Calogero A, Pani R, Petrozza V, Perotto G, Rizzi R, De Sio L.
Int J Mol Sci. 2022 Aug 23;23(17):9528.

Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes.
Wang Y, Chiola S, Yang G, Russell C, Armstrong CJ, Wu Y, Spampanato J, Tarboton P, Ullah HMA, Edgar NU, Chang AN, Harmin DA, Bocchi VD, Vezzoli E, Besusso D, Cui J, Cattaneo E, Kubanek J, Shcheglovitov A.
Nat Commun. 2022 Oct 6;13(1):5688.

The ABA-LANCL1/2 Hormone-Receptors System Protects H9c2 Cardiomyocytes from Hypoxia-Induced Mitochondrial Injury via an AMPK- and NO-Mediated Mechanism.
Spinelli S, Guida L, Vigliarolo T, Passalacqua M, Begani G, Magnone M, Sturla L, Benzi A, Ameri P, Lazzarini E, Bearzi C, Rizzi R, Zocchi E. Cells.2022 Sep 15;11(18):2888.

ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies.
Low JS, Jerak J, Tortorici MA, McCallum M, Pinto D, Cassotta A, Foglierini M, Mele F, Abdelnabi R, Weynand B, Noack J, Montiel-Ruiz M, Bianchi S, Benigni F, Sprugasci N, Joshi A, Bowen JE, Stewart C, Rexhepaj M, Walls AC, Jarrossay D, Morone D, Paparoditis P, Garzoni C, Ferrari P, Ceschi A, Neyts J, Purcell LA, Snell G, Corti D, Lanzavecchia A, Veesler D, Sallusto F.
Science. 2022 Aug 12;377(6607):735-742.

Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein.
Tortorici MA, Walls AC, Joshi A, Park YJ, Eguia RT, Miranda MC, Kepl E, Dosey A, Stevens-Ayers T, Boeckh MJ, Telenti A, Lanzavecchia A, King NP, Corti D, Bloom JD, Veesler D.
Cell. 2022 Jun 23;185(13):2279-2291.e17

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift.
Cameroni E, Saliba C, Bowen JE, Rosen LE, Culap K, Pinto D, De Marco A, Zepeda SK, di Iulio J, Zatta F, Kaiser H, Noack J, Farhat N, Czudnochowski N, Havenar-Daughton C, Sprouse KR, Dillen JR, Powell AE, Chen A, Maher C, Yin L, Sun D, Soriaga L, Gustafsson C, Franko NM, Logue J, Iqbal NT, Mazzitelli I, Geffner J, Grifantini R, Chu H, Gori A, Riva A, Giannini O, Ceschi A, Ferrari P, Franzetti-Pellanda A, Garzoni C, Hebner C, Purcell LA, Piccoli L, Pizzuto MS, Walls AC, Telenti A, Virgin HW, Lanzavecchia A, Veesler D, Snell G, Corti D.
Nature. 2022 Feb;602(7898):664-670.

A Multiscale Study of Phosphorylcholine Driven Cellular Phenotypic Targeting.
Acosta-Gutiérrez S, Matias D, Avila-Olias M, Gouveia VM, Scarpa E, Forth J, Contini C, Duro-Castano A, Rizzello L, Battaglia G.
ACS Cent Sci. 2022 Jul 27;8(7):891-904.

Tracking circulating tumour-associated T cells for the early diagnosis of cancer
Notarbartolo S.
Clinical and Translational Discovery 2022;2:e88.

Production of anti-PF4 antibodies in antiphospholipid antibody-positive patients is not affected by COVID-19 vaccination.
Lonati PA, Bodio C, Scavone M, Martini G, Pesce E, Bandera A, Lombardi A, Gerosa M, Franceschini F, Tincani A, Podda G, Abrignani S, Grifantini R, Cattaneo M, Borghi MO, Meroni PL.
RMD Open. 2022 Feb;8(1):e001902.

In vitro-derived medium spiny neurons recapitulate human striatal development and complexity at single-cell resolution.
Conforti P, Bocchi VD, Campus I, Scaramuzza L, Galimberti M, Lischetti T, Talpo F, Pedrazzoli M, Murgia A, Ferrari I, Cordiglieri C, Fasciani A, Arenas E, Felsenfeld D, Biella G, Besusso D, Cattaneo E.
Cell Rep Methods. 2022 Dec 19;2(12):100367.

Evaluation of humoral and cellular response to four vaccines against COVID-19 in different age groups: A longitudinal study.
Fedele G, Trentini F, Schiavoni I, Abrignani S, Antonelli G, Baldo V, Baldovin T, Bandera A, Bonura F, Clerici P, De Paschale M, Fortunato F, Gori A, Grifantini R, Icardi G, Lazzarotto T, Lodi V, Mastroianni CM, Orsi A, Prato R, Restivo V, Carsetti R, Piano Mortari E, Leone P, Olivetta E, Fiore S, Di Martino A, Brusaferro S, Merler S, Palamara AT, Stefanelli P.
Front Immunol. 2022 Oct 31;13:1021396.

ISG15 deficiency restricts HIV-1 infection.
Jurczyszak D, Manganaro L, Buta S, Gruber C, Martin-Fernandez M, Taft J, Patel RS, Cipolla M, Alshammary H, Mulder LCF, Sachidanandam R, Bogunovic D, Simon V.
PLoS Pathog. 2022 Mar 25;18(3):e1010405.

Development of an HIV reporter virus that identifies latently infected CD4+ T cells.
Kim EH, Manganaro L, Schotsaert M, Brown BD, Mulder LCF, Simon V.
Cell Rep Methods. 2022 Jun 13;2(6):100238.

Impaired seroconversion after SARS-CoV-2 mRNA vaccines in patients with solid tumours receiving anticancer treatment.
Amatu A, Pani A, Patelli G, Gagliardi OM, Loparco M, Piscazzi D, Cassingena A, Tosi F, Ghezzi S, Campisi D, Grifantini R, Abrignani S, Siena S, Scaglione F, Sartore-Bianchi A.
Eur J Cancer. 2022 Mar;163:16-25.

Clonal structure, stability and dynamics of human memory B cells and circulating plasmablasts.
Phad GE, Pinto D, Foglierini M, Akhmedov M, Rossi RL, Malvicini E, Cassotta A, Fregni CS, Bruno L, Sallusto F, Lanzavecchia A.
Nat Immunol. 2022 Jul;23(7):1-10.

Fate mapping and scRNA sequencing reveal origin and diversity of lymph node stromal precursors.
Lenti E, Genovese L, Bianchessi S, Maurizio A, Sain SB, di Lillo A, Mattavelli G, Harel I, Bernassola F, Hehlgans T, Pfeffer K, Crosti M, Abrignani S, Evans SM, Sitia G, Guimarães-Camboa N, Russo V, van de Pavert SA, Garcia-Manteiga JM, Brendolan A.
Immunity. 2022 Apr 12;55(4):606-622.e6.

Anti-Phospholipid Antibodies and Coronavirus Disease 2019: Vaccination Does Not Trigger Early Autoantibody Production in Healthcare Workers.
Borghi MO, Bombaci M, Bodio C, Lonati PA, Gobbini A, Lorenzo M, Torresani E, Dubini A, Bulgarelli I, Solari F, Pregnolato F, Bandera A, Gori A, Parati G, Abrignani S, Grifantini R, Meroni PL.
Front Immunol. 2022 Jul 15;13:930074.

Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination.
Brasu N, Elia I, Russo V, Montacchiesi G, Stabile SA, De Intinis C, Fesi F, Gizzi K, Macagno M, Montone M, Mussolin B, Grifoni A, Faravelli S, Marchese S, Forneris F, De Francesco R, Sette A, Barnaba V, Sottile A, Sapino A, Pace L.
Nat Immunol. 2022 Oct;23(10):1445-1456.

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody.
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB.
Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2120976119.

Discovery and antiviral profile of new sulfamoylbenzamide derivatives as HBV capsid assembly modulators.
Ivanova Bencheva L, Donnici L, Ferrante L, Prandi A, Sinisi R, De Matteo M, Randazzo P, Conti M, Di Lucia P, Bono E, Giustini L, Vittoria Orsale M, Patsilinakos A, Monteagudo E, Iannacone M, Summa V, Guidotti LG, De Francesco R, Di Fabio R.
Bioorg Med Chem Lett. 2022 Oct 1;73:128904.

DNA-Vaccine-Induced Immune Response Correlates with Lower Viral SARS-CoV-2 Titers in a Ferret Model
Compagnone M, Pinto E, Salvatori E, Lione L, Conforti A, Marchese S, Rava M, Ryan K, Hall Y, Rayner E, Salguero FJ, Paterson J, Iannacone M,
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Vaccines (Basel). 2022 Jul 25;10(8):1178.

Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccinees.
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Nat Commun. 2022 Jun 13;13(1):3375.

The dominant p.Thr274Pro mutation in the von Willebrand factor propeptide causes the von Willebrand disease type 1 phenotype in two unrelated patients.
Pagliari MT, Baronciani L, Cordiglieri C, Colpani P, Cozzi G, Siboni SM, Peyvandi F.
Haemophilia. 2022 Mar;28(2):292-300.

Unusual Association of NF-κB Components in Tumor-Associated Macrophages (TAMs) Promotes HSPG2-Mediated Immune-Escaping Mechanism in Breast Cancer.
De Paolis V, Maiullari F, Chirivì M, Milan M, Cordiglieri C, Pagano F, La Manna AR, De Falco E, Bearzi C, Rizzi R, Parisi C.
Int J Mol Sci. 2022 Jul 18;23(14):7902.

Strategies of Epstein-Barr virus to evade innate antiviral immunity of its human host.
Albanese M, Tagawa T, Hammerschmidt W.
Front Microbiol. 2022 Jul 22;13:955603.

Maturation signatures of conventional dendritic cell subtypes in COVID-19 suggest direct viral sensing.
Marongiu L, Protti G, Facchini FA, Valache M, Mingozzi F, Ranzani V, Putignano AR, Salviati L, Bevilacqua V, Curti S, Crosti M, Sarnicola ML, D’Angiò M, Bettini LR, Biondi A, Nespoli L, Tamini N, Clementi N, Mancini N, Abrignani S, Spreafico R, Granucci F.
Eur J Immunol. 2021 Aug 1:10.1002/eji.202149298.

Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
Bowen J E, Addetia A, Dang Ha V, Stewart C, Brown J T, Sharkey W K, Sprouse K R, Walls A C, Mazzitelli I C, Logue J K, Franko N M, Czudnochowski N, Powell A E, Dellota E Jr, Ahmed K, Shariq Ansari A, Cameroni E, Gori A, Bandera A, Posavad C M, Dan J M, Zhang Z, Weiskopf D, Sette A, Shane Crotty S, Talat Iqba N, Corti D, Geffner J, Snell G, Grifantini R, Chu E Y, Veesler D
Science, 19 Jul 2022, First Release, DOI: 10.1126/science.abq0203

Deep Phenotyping of T-Cells Derived From the Aneurysm Wall in a Pediatric Case of Subarachnoid Hemorrhage.
Moschetti G, Vasco C, Clemente F, Galeota E, Carbonara M, Pluderi M, Locatelli M, Stocchetti N, Abrignani S, Zanier ER, Ortolano F, Zoerle T, Geginat J.
Front Immunol. 2022 May 31;13:866558.

Immunosuppressant Treatment in Rheumatic Musculoskeletal Diseases Does Not Inhibit Elicitation of Humoral Response to SARS-CoV-2 Infection and Preserves Effector Immune Cell Populations
Favalli A, Favalli E G, Gobbini A, Zagato E, Bombaci M, Maioli G, Pesce E, Donnici L, Gruarin P, Biggioggero M, Curti S, Manganaro L, Marchisio E, Bevilacqua V, Martinovic M, Fabbris T, 1 , Sarnicola ML, Crosti M, Marongiu L, Granucci F, Notarbartolo S, Bandera A, Gori A, De Francesco R, Abrignani S, Caporali R, Grifantini R.
Front Immunol. 2022 Jun 10;13:873195. doi: 10.3389/fimmu.2022.873195. eCollection 2022.

Heterogeneity of Latency Establishment in the Different Human CD4+ T Cell Subsets Stimulated with IL-15.
Butta GM, Bozzi G, Gallo G, Copaloni G, Cordiglieri C, Crosti M, Mancino M, Prati D, Simon V, Gori A, Bandera A, De Francesco R, Manganaro L.
J Virol. 2022 May 2:e0037922.

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody.
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB.
Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2120976119.

Synthetic Carbohydrate Binding Agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2
Francesconi O, Donnici L, Fragai M, Pesce E, Bombaci M, Fasciani A, Manganaro L, Conti M, Grifantini R, De Francesco R, Nativi C, Roelens S.
iScience. 2022 May 20;25(5):104239. Epub 2022 Apr 11.PMID: 35434540.

The impact of anti-rheumatic drugs on the seroprevalence of anti-SARS-CoV-2 antibodies in a cohort of patients with inflammatory arthritis: the MAINSTREAM study
Favalli EG, Gobbini A, Bombaci M, Maioli G, Biggioggero M, Pesce E, Favalli A, Martinovic M, Fabbris T, Marchisio E, Bandiera A, Gori A, Abrignani S, Grifantini RG and Caporali R.
Frontiers in medicine, 2022 Mar 11

Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia.
Poli V, Di Gioia M, Sola-Visner M, Granucci F, Frelinger AL 3rd, Michelson AD, Zanoni I.
Immunity. 2022 Feb 8;55(2):224-236.e5.

Pulmonary Langerhans cell histiocystosis (PLCH) and lymphangioleiomyomatosis (LAM) have circulating cells with loss of heterozygosity of the TSC2 gene.
Elia D, Torre O, Vasco C, Geginat J, Abrignani S, Bulgheroni E, Carelli E, Cassandro R, Pacheco-Rodriguez G, Steagall WK, Moss J, Harari S.
Chest. 2022 Feb 26:S0012-3692(22)00398-1.

Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response
Pesce E, Manfrini N, Cordiglieri C, Santi S, Bandera A, Gobbini A, Gruarin P, Favalli A, Bombaci M, Cuomo A, Collino F, Cricrì G, Ungaro R, Lombardi A, Mangioni D, Muscatello A, Aliberti S, Blasi F, Gori A, Abrignani S, De Francesco R, Biffo S and Grifantini R.
Front. Immunol., 2022 Jan 17, doi.org/10.3389/fimmu.2021.785941

LINE1 elements are spliced in non-canonical transcript variants to control gene expression in human T cell quiescence and exhaustion
Marasca F, Sinha S, Vadalà R, Polimeni B, Ranzani V, Paraboschi E, Burattin FV, Ghilotti M, Crosti MC, Negri ML, Campagnoli S, Notarbartolo S, Bianchi AS, Siena S, Prati D, Montini G, Viale G, Torre O, Harari S, Grifantini R, Soldà G, Biffo S, Abrignani S, Bodega B.
Nat Genet. 2022 Jan 17, doi: 10.1038/s41588-021-00989-7.

Anti-spike antibodies and neutralising antibody activity in people living with HIV vaccinated with COVID-19 mRNA-1273 vaccine: a prospective single-centre cohort study.
Lombardi A, Butta GM, Donnici L, Bozzi G, Oggioni M, Bono P, Matera M, Consonni D, Ludovisi S, Muscatello A, Ceriotti F, Conti M, Scaglioni S, Gallo G, Scarpa E, Letko M, Abrignani S, Grifantini R, De Francesco R, Gori A, Manganaro L, Bandera A.
Lancet Reg Health Eur. 2022 Feb;13:100287

Production of anti-PF4 antibodies in antiphospholipid antibody-positive patients is not affected by COVID-19 vaccination
Lonati PA, Bodio C, Scavone M, Martini G, Pesce E, Bandera A, Lombardi A, Gerosa M, Franceschini F, Tincani A, Podda G, Abrignani S, Grifantini R, Cattaneo M, Borghi MO, Meroni PL.
RMD Open. 2022 Feb;8(1):e001902. doi: 10.1136/rmdopen-2021-001902.

Untargeted Mass Spectrometry Approach to Study SARS-CoV-2 Proteins in Human Plasma and Saliva Proteome
Pagani L, Chinello C, Mahajneh A, Clerici F, Criscuolo L, Favalli A, Gruarin P, Grifantini RM, Bandera A, Lombardi A, Ungaro R, Muscatello A, Blasi F, Gori A, Magni F.
BioChem. 2022, Feb 8; 2(1), 64-82

Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion
Fumagalli V, Ravà M, Marotta D, Di Lucia P, Laura C, Sala E, Grillo M, Bono E, Giustini L, Perucchini C, Mainetti M, Sessa A, Garcia-Manteiga JM, Donnici L, Manganaro L, Delbue S, Broccoli V, De Francesco R, D’Adamo P, Kuka M, Guidotti LG, Iannacone M.
Sci Immunol. 2022 Jan 28;7(67):eabl9929. doi: 10.1126/sciimmunol.abl9929. Epub 2022 Jan 28.

The dominant p.Thr274Pro mutation in the von Willebrand factor propeptide causes the von Willebrand disease type 1 phenotype in two unrelated patients.
Pagliari MT, Baronciani L, Cordiglieri C, Colpani P, Cozzi G, Siboni SM, Peyvandi F.
Haemophilia. 2022 Jan 22. doi: 10.1111/hae.14494

DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic
Villa A, Brunialti E, Dellavedova J, Meda C, Rebecchi M, Conti M, Donnici L, De Francesco R, Reggiani A, Lionetti V, Ciana P.
Pharmacol Res. 2022 Jan;175:105982.

COVID-eVax, an electroporated plasmid DNA vaccine candidate encoding the SARS-CoV-2 Receptor Binding Domain, elicits protective immune responses in animal models of COVID-19
Conforti A, Marra E, Palombo F, Roscilli G, Ravà M, Fumagalli V, Muzi A, Maffei M, Luberto L, Lione L, Salvatori E, Compagnone M, Pinto E, Pavoni E, Bucci F, Vitagliano G, Stoppoloni D, Pacello ML, Cappelletti M, Ferrara FF, D’Acunto E, Chiarini V, Arriga R, Nyska A, Di Lucia P, Marotta D, Bono E, Giustini L, Sala E, Perucchini C, Paterson J, Ryan KA, Challis AR, Matusali G, Colavita F, Caselli G, Criscuolo E, Clementi N, Mancini N, Groß R, Seidel A, Wettstein L, Münch J, Donnici L, Conti M, De Francesco R, Kuka M, Ciliberto G, Castilletti C, Capobianchi MR, Ippolito G, Guidotti LG, Rovati L, Iannacone M, Aurisicchio L.
Mol Ther. 2022 Jan 5;30(1):311-326

Elucidating the 3D Structure of a Surface Membrane Antigen from Trypanosoma cruzi as a Serodiagnostic Biomarker of Chagas Disease
Di Pisa F, De Benedetti S, Fassi EMA, Bombaci M, Grifantini R, Musicò A, Frigerio R, Pontillo A, Rigo C, Abelli S, Grande R, Zanchetta N, Mileto D, Mancon A, Rizzo A, Gori A, Cretich M, Colombo G, Bolognesi M, Gourlay LJ.
Vaccines (Basel). 2022 Jan 3;10(1):71

Impaired seroconversion after SARS-CoV-2 mRNA vaccines in patients with solid tumours receiving anticancer treatment.
Amatu A, Pani A, Patelli G, Gagliardi OM, Loparco M, Piscazzi D, Cassingena A, Tosi F, Ghezzi S, Campisi D, Grifantini R, Abrignani S, Siena S, Scaglione F, Sartore-Bianchi A.
Eur J Cancer. 2021 Dec 22;163:16-25.

MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells
Albanese M, Chen YA, Hüls C, Gärtner K, Tagawa T, Mejias-Perez E, Keppler OT, Göbel C, Zeidler R, Shein M, Schütz AK, Hammerschmidt W.
PLoS Genet. 2021 Dec 6;17(12):e1009951.

Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analyses
Albanese M, Ruhle A, Mittermaier J, Mejías-Pérez E, Gapp M, Linder A, Schmacke NA, Hofmann K, Hennrich AA, Levy DN, Humpe A, Conzelmann KK, Hornung V, Fackler OT, Keppler OT.
Nat Methods. 2022 Jan;19(1):81-89. Epub 2021 Dec 23.

SARS-CoV-2 spike conformation determines plasma neutralizing activity.
Bowen JE, Walls AC, Joshi A, Sprouse KR, Stewart C, Tortorici MA, Franko NM, Logue JK, Mazzitelli IG, Tiles SW, Ahmed K, Shariq A, Snell G, Iqbal NT, Geffner J, Bandera A, Gori A, Grifantini R, Chu HY, Van Voorhis WC, Corti D, Veesler D.
bioRxiv. 2021 Dec 21:2021.12.19.473391. doi: 10.1101/2021.12.19.473391. Preprint.

Anti-spike antibodies and neutralising antibody activity in people living with HIV vaccinated with COVID-19 mRNA-1273 vaccine: a prospective single-centre cohort study.
Lombardi A, Butta GM, Donnici L, Bozzi G, Oggioni M, Bono P, Matera M, Consonni D, Ludovisi S, Muscatello A, Ceriotti F, Conti M, Scaglioni S, Gallo G, Scarpa E, Letko M, Abrignani S, Grifantini R, De Francesco R, Gori A, Manganaro L, Bandera A.
Lancet Reg Health Eur. 2021 Dec 23:100287.

Exceptionally potent human monoclonal antibodies are effective for prophylaxis and treatment of tetanus in mice.
Pirazzini M, Grinzato A, Corti D, Barbieri S, Leka O, Vallese F, Tonellato M, Silacci-Fregni C, Piccoli L, Kandiah E, Schiavo G, Zanotti G, Lanzavecchia A, Montecucco C.
J Clin Invest. 2021 Nov 15;131(22):e151676. doi: 10.1172/JCI151676.

Assessment of Sacsin Turnover in Patients With ARSACS: Implications for Molecular Diagnosis and Pathogenesis.
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Neurology. 2021 Oct 14:10.1212/WNL.0000000000012962.

How dendritic cells sense and respond to viral infections.
Marongiu L, Valache M, Facchini FA, Granucci F.
Clin Sci (Lond). 2021 Oct 14;135(19):2217-2242.

ERα-independent NRF2-mediated immunoregulatory activity of tamoxifen.
Pepe G, Sfogliarini C, Rizzello L, Battaglia G, Pinna C, Rovati G, Ciana P, Brunialti E, Mornata F, Maggi A, Locati M, Vegeto E.
Biomed Pharmacother. 2021 Oct 12;144:112274.

Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies
Celikkin N, Presutti D, Maiullari F, Fornetti E, Agarwal T, Paradiso A, Volpi M, Swieszkowski W, Bearzi C, Barbetta A, Zhang YS, Gargioli C, Rizzi R and Costantini M.
Front. Bioeng. Biotechnol. 2021 Sept. 16, 9:732130. doi: 10.3389/fbioe.2021.732130

Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R
De Simone M, Chirichella M, Emming S, Mazzara S, Ranzani V, Gruarin P, Moschetti G, Pulvirenti N, Maglie S, Vasco C, Crosti MC, Rossetti G, Pagani M, Abrignani S, Monticelli S, Geginat J.
Eur J Immunol. 2021 Sep 15. doi: 10.1002/eji.202149315.

Novel interferon‑sensitive genes unveiled by correlation‑driven gene selection and systems biology
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Sci Rep. 2021 Sep 10;11(1):18043. doi: 10.1038/s41598-021-97258-8

Endosomal trafficking and DNA damage checkpoint kinases dictate survival to replication stress by regulating amino acid uptake and protein synthesis.
Ajazi A, Bruhn C, Shubassi G, Lucca C, Ferrari E, Cattaneo A, Bachi A, Manfrini N, Biffo S, Martini E, Minucci S, Vernieri C, Foiani M.
Dev Cell. 2021 Sep 8:S1534-5807(21)00678-X.

Targeting HDAC8 to ameliorate skeletal muscle differentiation in Duchenne muscular dystrophy.
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Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients.
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Sci Immunol. 2021 Aug 10;6(62):eabg5021.

Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma.
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Nat Commun. 2021 Aug 12;12(1):4878.

Phosphorylation of H3-Thr3 by Haspin Is Required for Primary Cilia Regulation.
Quadri R, Sertic S, Ghilardi A, Rondelli D, Gallo GR, Del Giacco L, Muzi-Falconi M.
Int J Mol Sci. 2021 Jul 20;22(14):7753.

Synergistic Effect Induced by Gold Nanoparticles with Polyphenols Shell during Thermal Therapy: Macrophage Inflammatory Response and Cancer Cell Death Assessment.
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Cancers (Basel). 2021 Jul 19;13(14):3610.

Focus on the road to modelling cardiomyopathy in muscular dystrophy
Canonico F, Chirivi M, Maiullari F, Milan M, Rizzi R, Arcudi A, Galli M, Pane M, Gowran A, Pompilio G, Mercuri E, Crea F, Bearzi C, D’Amario D.
Cardiovascular Research, 2021 Jul 12;cvab232. doi: 10.1093/cvr/cvab232.

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs
Xu K, Wang Y, Shen CH, Chen Y, Zhang B, Liu K, Tsybovsky Y, Wang S, Farney SK, Gorman J, Stephens T, Verardi R, Yang Y, Zhou T, Chuang GY, Lanzavecchia A, Piccoli L, Kwong PD.
Nat Commun. 2021 Jul 9;12(1):4226.

Pre-Drawn Syringes of Comirnaty for an Efficient COVID-19 Mass Vaccination: Demonstration of Stability.
Selmin F, Musazzi UM, Franzè S, Scarpa E, Rizzello L, Procacci P, Minghetti P.
Pharmaceutics. 2021 Jul 7;13(7):1029.

Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2
Low JS, Vaqueirinho D, Mele F, Foglierini M, Jerak J, Perotti M, Jarrossay D, Jovic S, Perez L, Cacciatore R, Terrot T, Pellanda AF, Biggiogero M, Garzoni C, Ferrari P, Ceschi A, Lanzavecchia A, Sallusto F, Cassotta A.
Science. 2021 Jun 18;372(6548):1336-1341.Epub 2021 May 18.

ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington’s disease
Cozzolino F, Vezzoli E, Cheroni C, Besusso D, Conforti P, Valenza M, Iacobucci I, Monaco V, Birolini, Bombaci M, Falqui A, Saftig P, Rossi R, Monti M, Cattaneo E, Zuccato C.
Hum Mol Genet. 2021 Jun 17;30(13):1175-1187. doi: 10.1093/hmg/ddab047

Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression.
Bonnal RJP, Rossetti G, Lugli E, De Simone M, Gruarin P, Brummelman J, Drufuca L, Passaro M, Bason R, Gervasoni F, Della Chiara G, D’Oria C, Martinovic M, Curti S, Ranzani V, Cordiglieri C, Alvisi G, Mazza EMC, Oliveto S, Silvestri Y, Carelli E, Mazzara S, Bosotti R, Sarnicola ML, Godano C, Bevilacqua V, Lorenzo M, Siena S, Bonoldi E, Sartore-Bianchi A, Amatu A, Veronesi G, Novellis P, Alloisio M, Giani A, Zucchini N, Opocher E, Ceretti AP, Mariani N, Biffo S, Prati D, Bardelli A, Geginat J, Lanzavecchia A, Abrignani S, Pagani M.
Nat Immunol. 2021 May 20. doi: 10.1038/s41590-021-00930-4.

A High-Throughput Chromatin Immunoprecipitation Sequencing Approach to Study the Role of MYC on the Epigenetic Landscape
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Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties.
Lucà R, Assenza MR, Maiullari F, Pieroni L, Maiullari S, Federici G, Marini F, Rizzi R, Urbani A, Soddu S, Moretti F.
Cell Death Dis. 2021 May 29;12(6):558. doi: 10.1038/s41419-021-03828-z.

The coding and long noncoding single-cell atlas of the developing human fetal striatum.
Bocchi VD, Conforti P, Vezzoli E, Besusso D, Cappadona C, Lischetti T, Galimberti M, Ranzani V, Bonnal RJP, De Simone M, Rossetti G, He X, Kamimoto K, Espuny-Camacho I, Faedo A, Gervasoni F, Vuono R, Morris SA, Chen J, Felsenfeld D, Pavesi G, Barker RA, Pagani M, Cattaneo E.
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Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
Della Chiara G, Gervasoni F, Fakiola M, Godano C, D’Oria C, Azzolin L, Bonnal RJP, Moreni G, Drufuca L, Rossetti G, Ranzani V, Bason R, De Simone M, Panariello F, Ferrari I, Fabbris T, Zanconato F, Forcato M, Romano O, Caroli J, Gruarin P, Sarnicola ML, Cordenonsi M, Bardelli A, Zucchini N, Pisani Ceretti A, Mariani NM, Cassingena A, Sartore-Bianchi A, Testa G, Gianotti L, Opocher E, Pisati F, Tripodo C, Macino G, Siena S, Bicciato S, Piccolo S, Pagani M.
Nat Commun. 2021 Apr 20;12(1):2340.doi: 10.1038/s41467-021-22544-y

Structure, Immunoreactivity, and In Silico Epitope Determination of SmSPI S. mansoni Serpin for Immunodiagnostic Application.
De Benedetti, S., Di Pisa, F., Fassi, E., Cretich, M., Musicò, A., Frigerio, R., Mussida, A., Bombaci, M., Grifantini, R., Colombo, G., Bolognesi, M., Grande, R., Zanchetta, N., Gismondo, M. R., Mileto, D., Mancon, A., & Gourlay, L. J. Gourlay.
Vaccines (Basel) 2021 Apr 1;9(4):322. doi: 10.3390/vaccines9040322

Engineering Polymeric Nanosystems against Oral Diseases.
Mercadante V, Scarpa E, De Matteis V, Rizzello L, Poma A.
Molecules. 2021 Apr 13;26(8):2229.

Tumor Extracellular Matrix Stiffness Promptly Modulates the Phenotype and Gene Expression of Infiltrating T Lymphocytes
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Geographic differences in the incidence of Huntington’s disease in Sardinia, Italy.
Muroni A, Murru MR, Ulgheri L, Sechi M, Ercoli T, Marrosu F, Scaglione CL, Bentivoglio AR, Petracca M, Soliveri P, Cocco E, Cuccu S, Deriu M, Zuccato C, Defazio G.
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Role of Cdkn2a in the Emery–Dreifuss Muscular Dystrophy Cardiac Phenotype
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Biomolecules. 2021 Apr 6;11(4):538. doi: 10.3390/biom11040538. PMID: 33917623

Huntingtin-mediated axonal transport requires arginine methylation by PRMT6.
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Development of a Specific Monoclonal Antibody to Detect Male Cells Expressing the RPS4Y1 Protein
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Int J Mol Sci. 2021 Feb 18;22(4):2001. doi: 10.3390/ijms22042001.

SREBP2 delivery to striatal astrocytes normalizes transcription of cholesterol biosynthesis genes and ameliorates pathological features in Huntington’s disease
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Formaldehyde-mediated snapshot of nuclear architecture
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Chemotherapy triggers cachexia by deregulating synergetic function of histone-modifying enzymes
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J Cachexia Sarcopenia Muscle 2021 Feb 12

Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells.
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hiPSCs for predictive modelling of neurodegenerative diseases: dreaming the possible
Rivetti di Val Cervo P, Besusso D, Conforti P & Cattaneo E.
Nature Reviews Neurology. 2021 Mar 3:1–12. doi: 10.1038/s41582-021-00465-0. Epub ahead of print. PMID: 33658662; PMCID: PMC7928200.

Early maternal care restores LINE-1 methylation and enhances neurodevelopment in preterm infants
Fontana C, Marasca F, Provitera L, Mancinelli S, Pesenti N, Sinha S, Passera S, Abrignani S, Mosca F, Lodato S, Bodega B, Fumagalli M.
BMC Med. 2021 Feb 5;19(1):42.

Modeling autism-associated SHANK3 deficiency using human cortico-striatal organoids generated from single neural rosettes
Wang Y, Chiola S, Yang G, Russell C, Armstrong C J, Wu Y, Spampanato J, Tarboton P, Chang A N, Harmin D A, Vezzoli E, Besusso D, Cui J, Cattaneo E, Kubanek J, Shcheglovitov A.
bioRxiv preprint, version posted January 25, 2021, doi:https://doi.org/ 10.1101/2021.01.25.428022

Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington’s disease
Birolini G, Valenza M, Ottonelli I, Passoni A, Favagrossa M, Duskey JT, Bombaci M, Vandelli MA, Colombo L, Bagnati R, Caccia C, Leoni V, Taroni F, Forni F, Ruozi B, Salmona M, Tosi G, Cattaneo E.
J Control Release. 2021 Jan 5;330:587-598.

In vivo organized neovascularization induced by 3D bioprinted endothelial-derived extracellular vesicles
Maiullari F, Chirivì M, Costantini M, Ferretti AM, Recchia S, Maiullari S, Milan M, Presutti D, Pace V, Raspa M, Scavizzi F, Massetti M, Petrella L, Fanelli M, Rizzi M, Fortunato O, Moretti F, Caradonna E, Bearzi C, Rizzi R.
Biofabrication. 2021 Jan 12. doi: 10.1088/1758-5090/abdacf.

PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity.
Poli A, Abdul-Hamid S, Zaurito AE, Campagnoli F, Bevilacqua V, Sheth B, Fiume R, Pagani M, Abrignani S, Divecha N.
Proc Natl Acad Sci U S A. 2021 Aug 3;118(31):e2010053118

The enhancement of activity rescues the establishment of Mecp2 null neuronal phenotypes.
Scaramuzza L, De Rocco G, Desiato G, Cobolli Gigli C, Chiacchiaretta M, Mirabella F, Pozzi D, De Simone M, Conforti P, Pagani M, Benfenati F, Cesca F, Bedogni F, Landsberger N.
EMBO Mol Med. 2021 Apr 9;13(4):e12433.

Prevalence of Huntington’s disease in Southern Sardinia, Italy.
Muroni A, Murru MR, Sechi M, Ercoli T, Marrosu F, Bentivoglio AR, Petracca M, Maria Scaglione CL, Soliveri P, Cocco E, Pedron M, Murgia M, Deriu M, Cuccu S, Ulgheri L, Zuccato C, Defazio G.
Parkinsonism Relat Disord. 2020 Nov;80:54-57. doi: 10.1016/j.parkreldis.2020.09.011.

SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome
Sebestyén E, Marullo F, Lucini F, Petrini C, Bianchi A, Valsoni S, Olivieri I, Antonelli L, Gregoretti F, Oliva G, Ferrari F, Lanzuolo C.
Nat Commun. 2020 Dec 8;11(1):6274.

Alternative Splicing Generates a MONOPTEROS Isoform Required for Ovule Development
Cucinotta M,Cavalleri A, Guazzotti A, Astori C, Manrique S, Bombarely A, Oliveto S, Biffo S, Weijers D, Kater M.M., Colombo L.
Current Biology, Dec.3, 2020, doi.org/10.1016/j.cub.2020.11.026

Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington’s disease mice
Birolini G, Valenza M, Di Paolo E, Vezzoli E, Talpo F, Maniezzi C, Caccia C, Leoni V, Taroni F, Bocchi VD, Conforti P, Sogne E, Petricca L, Cariulo C, Verani M, Caricasole A, Falqui A, Biella G, Cattaneo E.
EMBO Molecular Medicine, 2020 Epub ahead of print. 12(10):e12519

A CRISPR-strategy for the generation of a detectable fluorescent hESC reporter line (WAe009-A-37) for the subpallial determinant GSX2
Besusso D, Cossu A, Mohamed A, Cernigoj M, Codega P, Galimberti M, Campus I, Conforti P, Cattaneo E.
Stem Cell Reports, 2020. 49:102016

New label-free methods for protein relative quantification applied to the investigation of an animal model of Huntington Disease
Cozzolino F, Landolfi A, Iacobucci I, Monaco V, Caterino M, Celentano S, Zuccato C, Cattaneo E, Monti M.
PLOS ONE, 2020. 15(9):e0238037.

MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome
Fasciani A, D’Annunzio S, Poli V, Fagnocchi L, Beyes S, Michelatti D, Corazza F, Antonelli L, Gregoretti F, Oliva G, Belli R, Peroni D, Domenici E, Zambrano S, Intartaglia D, Settembre C, Conte I, Testi C, Vergyris P, Ruocco G, Zippo A.
Nat Genet. 2020 Nov 9. doi: 10.1038/s41588-020-00724-8. Online ahead of print

P2X7 Receptor Activity Limits Accumulation of T Cells within Tumors
Romagnani A, Rottoli E, Mazza E, Rezzonico-Jost T, Ponte Conti B, Proietti M, Perotti M, Civanelli E, Perruzza L, Catapano A, Baragetti A, Tenedini E, Tagliafico E, Falzoni S, Di Virgilio F, Norata G, Bicciato S, Grassi F.
Cancer Res. 2020 Sep 15;80(18):3906-3919.

RUES2 hESCs exhibit MGE-biased neuronal differentiation and muHTT-dependent defective specification hinting at SP1
Conforti P, Besusso D, Brocchetti S, Campus I, Cappadona C, Galimberti M, Laporta A, Iennaco R, Rossi RL, Bocchi Dickinson V, Cattaneo E.
Neurobiology of Disease, Oct. 2020, doi.org/10.1016/j.nbd.2020.105140. In press.

FAM46C and FNDC3A are multiple myeloma tumor suppressors that act in concert to impair clearing of protein aggregates and autophagy
Manfrini N, Mancino M, Miluzio A, Oliveto S, Balestra M, Calamita P, Alfieri R, Rossi RL, Sassoè-Pognetto M, Salio C, Cuomo A, Bonaldi T, Manfredi M, Marengo E, Ranzato E, Martinotti S, Cittaro D, Tonon G, Biffo S.
Cancer Res. 2020 Sep 22;canres.1357.2020.

GADD34 is a modulator of autophagy during starvation
Gambardella G, Staiano L, Moretti MN, De Cegli R, Fagnocchi L, Di Tullio G, Polletti S, Braccia C, Armirotti A, Zippo A, Ballabio A, De Matteis MA, Di Bernardo D.
Sci Adv. 2020 Sep 25;6(39)

Frataxin gene editing rescues Friedreich’s ataxia pathology in dorsal root ganglia organoid-derived sensory neurons
Mazzara PG, Muggeo S, Luoni M, Massimino L, Zaghi M, Tajalli-Tehrani Valverde P, Brusco S, Marzi MJ, Palma C, Colasante G, Iannielli A, Paulis M, Cordiglieri C, Giannelli SG, Podini P, Gellera C, Taroni F, Nicassio F, Rasponi M, Broccoli V
Nat Commun. 2020 Aug 21;11(1):4178. doi:10.1038/s41467-020-17954-3

Single Myofiber Isolation and Culture from a Murine Model of Emery-Dreifuss Muscular Dystrophy in Early Post-Natal Development
Pegoli G, Lucini F, Mozzetta C and Lanzuolo C
JoVE. 2020; Published July 1, 2020

Nanoparticle‐Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment
Salvioni L, Zuppone S, Andreata F, Monieri M, Mazzucchelli S, Di Carlo C, Morelli L, Cordiglieri C, Donnici L,
De Francesco R, Corsi F, Prosperi D, Vago R, and Colombo M
Adv. Therap.  2000007

Extracellular Vesicles From Skeletal Muscle Cells Efficiently Promote Myogenesis in Induced Pluripotent Stem Cells
Baci D, Chirivì M, Pace V, Maiullari F, Milan M, Rampin A, Somma P, Presutti D, Garavelli S, Bruno A, Cannata S, Lanzuolo C, Gargioli C, Rizzi R, Bearzi C.
Cells, 2020 Jun 23: E1527

Intermittent β-adrenergic blockade downregulates the gene expression of β-myosin heavy chain in the mouse heart
Maccari S, Pace V, Barbagallo F, Stati T, Ambrosio C, Grò MC, Molinari P, Vezzi V, Catalano L, Matarrese P, Patrizio M, Rizzi R, Marano G.
Eur J Pharmacol.  Available on line 2020 Jun 22:173287. doi:10.1016/j.ejphar.2020.173287. In press.

Type III interferons disrupt the lung epithelial barrier upon viral recognition
Broggi A, Ghosh S, Sposito B, Spreafico R, Balzarini F, Lo Cascio A, Clementi N, De Santis M, Mancini N, Granucci F, Zanoni I.
Science. 2020 Jun 11:eabc3545. doi: 10.1126/science.abc3545

Profound Alterations of the Chromatin Architecture at Chromosome 11p15.5 in Cells From Beckwith-Wiedemann and Silver-Russell Syndromes Patients
Rovina D, La Vecchia M, Cortesi A, Fontana L, Pesant M, Maitz S, Tabano S, Bodega B, Miozzo M, Sirchia S
Sci Rep. 2020 May 19;10(1):8275.

IRF4 Instructs Effector Treg Differentiation and Immune Suppression in Human Cancer
Alvisi G, Brummelman J, Puccio S, Mazza E Mc, Paoluzzi Tomada E, Losurdo A, Zanon V, Peano C, Colombo F S, Scarpa A, Alloisio M, Vasanthakumar A, Roychoudhuri R, Kallikourdis M, Pagani M, Lopci E, Novellis P, Blume J, Kallies A, Veronesi G, Lugli E.
J Clin Invest. 2020 May 11;130426. Online ahead of print.

The Sophisticated Transcriptional Response Governed by Transposable Elements in Human Health and Disease
Marasca F, Gasparotto E, Polimeni B, Vadalà R , Ranzani V, Bodega B.
Int J Mol Sci. 2020 Apr 30;21(9):E3201.

OligoMinerApp: A Web-Server Application for the Design of Genome-Scale Oligonucleotide in Situ Hybridization Probes Through the Flexible OligoMiner Environment
Passaro M, Martinovic M, Bevilacqua V, Hershberg E A, Rossetti G, Beliveau B, Bonnal RJP, Pagani M.
Nucleic Acids Res. 2020 Apr 20;gkaa251. Online ahead of print.

Dysfunctional polycomb transcriptional repression contributes to Lamin A/C dependent muscular dystrophy
Bianchi A, Mozzetta C, Pegoli G, Lucini F, Valsoni S, Rosti V, Petrini C, Cortesi A, Gregoretti F, Antonelli L, Oliva G, De Bardi M, Rizzi R, Bodega B, Pasini D, Ferrari F, Bearzi C, Lanzuolo C
J Clin Invest. 2020; May 2020; 130(5):2408-2421.

Ribosome profiling unveils translational regulation of metabolic enzymes in primary CD4+ Th1 cells
Manfrini N, Ricciardi S, Alfieri R, Ventura G, Calamita P, Favalli A, Biffo S.
Dev Comp Immunol. 2020 Aug;109:103697. Epub 2020 Apr 21

The Endless Frontier? The Recent Increase of R&D Productivity in Pharmaceuticals
Pammolli F, Righetto L, Abrignani S, Pani L, Pelicci PG, Rabosio E.
J Transl Med, 2020 Apr 9;18(1):162.doi:10.1186/s1296-020-02313-z.

DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis
Thiruvalluvan A, de Mattos EP, Brunsting JF, Bakels R, Serlidaki D, Barazzuol L, Conforti P, Fatima A, Koyuncu S, Cattaneo E, Vilchez D, Bergink S, Boddeke E H W G, Copray S, Kampinga HH.
Mol Cell, 2020 Mar 25;S1097-2765(20)30115-5. doi:10.1016/j.molcel.2020.02.022. Online ahead of print.

Evidence for a pathogenic role of extrafollicular, IL-10–producing CCR6+B helper T cells in systemic lupus erythematosus
Facciotti F, Larghi P, Bosotti R, Vasco C, Gagliani N, Cordiglieri C, Mazzara S, Ranzani V, Rottoli E, Curti S, Penatti A, Karnani B, Kobayashi Y, Crosti M, Bombaci M, van Hamburg JP, Rossetti G, Gualtierotti R, Gerosa M, Gatti S, Torretta S, Pignataro L, Tas SW, Abrignani S, Pagani M, Grassi F, Meroni PL, Flavell RA, and Geginat J.
PNAS , March 17,2020; http://doi. org/10.1073/pnas.1917834117.

Immunological variables associated with clinical and endoscopic response to vedolizumab in patients with inflammatory bowel diseases.
Coletta M, Paroni M, Alvisi MF, De Luca M, Rulli E, Mazza S, Facciotti F, Lattanzi G, Strati F, Abrignani S, Fantini MC, Vecchi M, Geginat J, Caprioli F.
J Crohns Colitis. 2020 Feb 26. pii: jjaa035. doi: 10.1093/ecco-jcc/jjaa035. [Epub ahead of print]

High-dose vitamin C enhances cancer immunotherapy.
Magrì A, Germano G, Lorenzato A, Lamba S, Chilà R, Montone M, Amodio V, Ceruti T, Sassi F, Arena S, Abrignani S, D’Incalci M, Zucchetti M, Di Nicolantonio F, Bardelli A.
Sci Transl Med. 2020 Feb 26;12(532). pii: eaay8707. doi: 10.1126/scitranslmed.aay8707.

Cellular and molecular mechanisms of antifungal innate immunity at epithelial barriers: The role of C-type lectin receptors
Borriello F, Zanoni I, Granucci F.
Eur J Immunol. 2020 Mar; 50 (3):317-325. Epub 2020 Feb 6.

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells 
Marasca F, Cortesi A, Manganaro L, Bodega B.
J Vis Exp 2020 Jan 25;(155)

Tumor-Educated Platelets and Angiogenesis in Glioblastoma: Another Brick in the Wall for Novel Prognostic and Targetable Biomarkers, Changing the Vision from a Localized Tumor to a Systemic Pathology
Campanella R, Guarnaccia L, Cordiglieri C, Trombetta E, Caroli M, Carrabba G, La Verde N, Rampini P, Gaudino C, Costa A, Luzzi S, Mantovani G, Locatelli M, Riboni L, Navone SE and Marfia G.
Cells 2020, 9, 294; doi:10.3390/cells9020294. Published: 25 January 2020

Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits
Pesce E, Miluzio A, Turcano L, Minici C, Cirino D, Calamita P, Manfrini N, Oliveto S, Ricciardi S, Grifantini R, Degano M, Bresciani A, Biffo S.
Cells. 2020 Jan 10; 9(1):172.

A Structurally Simple Vaccine Candidate Reduces Progression and Dissemination of Triple-Negative Breast Cancer
Amedei A, Asadzadeh F, Papi F, Vannucchi MG, Ferrucci V, Bermejo I A, Fragai M, Vieira De Almeida C, Cerofolini L, Giuntini S, Bombaci M, Pesce E, Niccolai E, Natali F, Guarini E, Gabel F, Traini C, Catarinicchia S, Ricci F, Orzalesi L, Berti F, Corzana F, Zollo M, Grifantini R and Nativi C.
iScience. 2020 Jun 26; 23(6): 101250. Published online 2020 Jun 6

Efficacy of Cholesterol Nose-to-Brain Delivery for Brain Targeting in Huntington’s Disease.
Passoni A, Favagrossa M, Colombo L, Bagnati R, Gobbi M, Diomede L, Birolini G, Di Paolo E, Valenza M, Cattaneo E, Salmona M.
ACS Chem Neurosci. 2020 Feb 5;11(3):367-372. doi: 10.1021/acschemneuro.9b00581. Epub 2020 Jan 7

Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion
Broggi A, Granucci F, Zanoni I.
J Exp Med. 2020 Jan 6; 217(1):e20190295.

The induction and function of the anti-inflammatory fate of T H 17 cells
Xu H, Agalioti T, Zhao J, Steglich , Wahib R, Amezcua Vesely MC, Bielecki P, Bailis W, Jackson R, Perez D, Izbicki J, Licona-Limón P, Kaartinen V, Geginat J, Esplugues E, Tolosa E, Huber S, Flavell R, Gagliani N.
Nat Commun. 2020 Jul 3;11(1):3334.

Huntingtin gene CAG repeat size affects autism risk: Family-based and case-control association study.
Piras IS, Picinelli C, Iennaco R, Baccarin M, Castronovo P, Tomaiuolo P, Cucinotta F, Ricciardello A, Turriziani L, Nanetti L, Mariotti C, Gellera C, Lintas C, Sacco R, Zuccato C, Cattaneo E, Persico AM.
Am J Med Genet B Neuropsychiatr Genet. 2020 Sep;183(6):341-351.

Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease.
Besusso D, Schellino R, Boido M, Belloli S, Parolisi R, Conforti P, Faedo A, Cernigoj M, Campus I, Laporta A, Bocchi VD, Murtaj V, Parmar M, Spaiardi P, Talpo F, Maniezzi C, Toselli MG, Biella G, Moresco RM, Vercelli A, Buffo A, Cattaneo E.
Stem Cell Reports. 2020 May 12;14(5):876-891.

Inflammatory interactions between degenerated intervertebral discs and microglia: Implication of sphingosine-1-phosphate signaling
Navone S, Campanella R, Guarnaccia L, Ouellet JA, Locatelli M, Cordiglieri C, Gualtierotti R, Gaudino C, Ciniglio Appiani G, Luzzi S, Borsa S, Rampini P, Pluderi M, Haglund L, Riboni L, Alini M, Marfia G.
J Orthop Res. 2020 Aug 11. doi: 10.1002/jor.24827.

A subset of colorectal cancers with cross-sensitivity to olaparib and oxaliplatin
Arena S, Corti G, Durinikova E, Montone M, Reilly NM, Russo M, Lorenzato A, Arcella P, Lazzari L, Rospo G, Pagani M1, Cancelliere C, Negrino C, Isella C, Bartolini A, Cassingena A, Amatu A, Mauri G, Sartore-Bianchi A, Mittica G, Medico E, Marsoni S, Linnebacher M, Abrignani S, Siena S, Di Nicolantonio F, Bardelli A.
Clin Cancer Res. 2020 Mar 15;26(6):1372-1384.

Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses
Iannielli A, Ugolini GS, Cordiglieri C, et al.
Cell Rep. 2019;29(13):4646–4656.e4.

IL-10 producing regulatory and helper T-cells in systemic lupus erythematosus.
Geginat J, Vasco M, Gerosa M, Tas SW, Pagani M, Grassi F, Flavell RA, Meroni P, Abrignani S.
Semin Immunol. 2019 Aug;44:101330.

Introduction to the Special Issue: Interleukin-10 “The surprising twists and turns of an anti-inflammatory cytokine on its way to the clinic”.
Geginat J.
Semin Immunol. 2019 Aug;44:101343.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
Cossarizza A. et al.
Eur J Immunol. 2019 Oct;49(10):1457-1973.

Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis.
López-Tobón A, Villa CE, Cheroni C, Trattaro S, Caporale N, Conforti P, Iennaco R, Lachgar M, Rigoli MT, Marcó de la Cruz B, Lo Riso P, Tenderini E, Troglio F, De Simone M, Liste-Noya I, Macino G, Pagani M, Cattaneo E, Testa G.
Stem Cell Reports. 2019 Oct 1. pii: S2213-6711(19)30334-0. [Epub ahead of print]

Modulating eIF6 levels unveils the role of translation in ecdysone biosynthesis during Drosophila development.
Russo A, Gatti G, Alfieri R, Pesce E, Soanes K, Ricciardi S, Mancino M, Cheroni C, Vaccari T, Biffo S, Calamita P.
Dev Biol. 2019 Nov 1;455(1):100-111.

SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring.
Sessa A, Fagnocchi L, Mastrototaro G, Massimino L, Zaghi M, Indrigo M, Cattaneo S, Martini D, Gabellini C, Pucci C, Fasciani A, Belli R, Taverna S, Andreazzoli M, Zippo A, Broccoli V.
Neuron. 2019 Sep 9. pii: S0896-6273(19)30639-7.

Dynamic and Cell-Specific DACH1 Expression in Human Neocortical and Striatal Development.
Castiglioni V, Faedo A, Onorati M, Bocchi VD, Li Z, Iennaco R, Vuono R, Bulfamante GP, Muzio L, Martino G, Sestan N, Barker RA, Cattaneo E.
Cereb Cortex. 2019 May 1;29(5):2115-2124.

Transcriptional blood signatures for active and amphotericin B treated visceral leishmaniasis in India.
Fakiola M, Singh OP, Syn G, Singh T, Singh B, Chakravarty J, Sundar S, Blackwell JM.
PLoS Negl Trop Dis. 2019 Aug 16;13(8)

Sharing Programming Resources Between Bio* Projects.
Bonnal RJP, Yates A, Goto N, Gautier L, Willis S, Fields C, Katayama T, Prins P.
Methods Mol Biol. 2019;1910:747-766.

Enrichment of intestinal Lactobacillus by enhanced secretory IgA coating alters glucose homeostasis in P2rx7-/- mice.
Perruzza L, Strati F, Gargari G, D’Erchia AM, Fosso B, Pesole G, Guglielmetti S, Grassi F.
Sci Rep. 2019 Jun 27;9(1):9315.

Modulating eIF6 levels unveils the role of translation in ecdysone biosynthesis during Drosophila development.
Russo A, Gatti G, Alfieri R, Pesce E, Soanes K, Ricciardi S, Mancino M, Cheroni C, Vaccari T, Biffo S, Calamita P.
Dev Biol. 2019 Jul 5. pii: S0012-1606(18)30796-6.

TNF-Stimulated Gene-6 Is a Key Regulator in Switching Stemness and Biological Properties of Mesenchymal Stem Cells.
Romano B, Elangovan S, Erreni M, Sala E, Petti L, Kunderfranco P, Massimino L, Restelli S,3, Sinha S, Lucchetti D, Anselmo A, Colombo FS, Stravalaci M, Arena V, D’Alessio S, Ungaro F, Inforzato A, Izzo AA, Sgambato A, Day AJ, Vetrano S.
Stem Cells. 2019; doi: 10.1002/stem.3010. [Epub ahead of print]

Phosphatidylinositol 5 Phosphate (PI5P): From Behind the Scenes to the Front (Nuclear) Stage.
Poli A, Zaurito AE, Abdul-Hamid S, Fiume R, Faenza I, Divecha N.
Int J Mol Sci. 2019 Apr 27;20(9).

FOXP1 circular RNA sustains mesenchymal stem cell identity via microRNA inhibition.
Cherubini A, Barilani M, Rossi RL, Jalal MMK, Rusconi F, Buono G, Ragni E, Cantarella G, Simpson HARW, Péault B, Lazzari L.
Nucleic Acids Res. 2019 Jun 4;47(10):5325-5340.

Allele-specific silencing as treatment for gene duplication disorders: proof-of-principle in autosomal dominant leukodystrophy.
Giorgio E, Lorenzati M, Rivetti di Val Cervo P, Brussino A, Cernigoj M, Della Sala E, Bartoletti Stella A, Ferrero M, Caiazzo M, Capellari S, Cortelli P, Conti L, Cattaneo E, Buffo A, Brusco A.
Brain. 2019 May 29. pii: awz139. [Epub ahead of print]

Pathologic up-regulation of TNFSF15-TNFRSF25 axis sustains endothelial dysfunction in unprovoked venous thromboembolism.
Bella SD, Calcaterra F, Bacci M, Carenza C, Pandolfo C, Ferrazzi P, Uva P, Pagani M, Lodigiani C, Mavilio D.
Cardiovasc Res. 2019 May 28. pii: cvz131. doi: 10.1093/cvr/cvz131. [Epub ahead of print]

4q-D4Z4 chromatin architecture regulates the transcription of muscle atrophic genes in Facioscapulohumeral muscular dystrophy
Cortesi A, Pesant M, Sinha S, Marasca M, Sala E, Gregoretti F, Antonelli L, Oliva G, Chiereghin C, Soldà G, Bodega B*.
Genome Res. 2019 May 16. pii: gr.233288.117. doi: 10.1101/gr.233288.117. [Epub ahead of print]

Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington’s Disease
Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo and Zuccato C.
Journal of Clinical Investigation 2019 May 6; 130. pii: 120616. doi: 10.1172/JCI120616. [in press]

Novel biomarkers for Primary Biliary Cholangitis to improve diagnosis and understand underlying regulatory mechanisms.
Bombaci M, Pesce E, Torri A, Carpi D, Crosti M, Lanzafame M, Cordiglieri C, Sinisi A, Moro M, Bernuzzi F, Gerussi A, Geginat J, Muratori L, Terracciano LM, Invernizzi P, Abrignani S, Grifantini R.
Liver Int. 2019 Apr 29. doi: 10.1111/liv.14128. [Epub ahead of print]

Chromium 10× Single-Cell 3′ mRNA Sequencing of Tumor-Infiltrating Lymphocytes
De Simone M, Rossetti G, Pagani M.
Methods Mol Biol. 2019;1979:87-110.

Computation and Selection of Optimal Biomarker Combinations by Integrative ROC Analysis Using CombiROC.
Bombaci M, Rossi RL.
Methods Mol Biol. (2019);1959:247-259.

Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease.
Pelusi S, Baselli G, Pietrelli A, Dongiovanni P, Donati B, McCain MV, Meroni M, Fracanzani AL, Romagnoli R, Petta S, Grieco A, Miele L, Soardo G, Bugianesi E, Fargion S, Aghemo A, D’Ambrosio R, Xing C, Romeo S, De Francesco R, Reeves HL, Valenti LVC.
Sci Rep. 2019 Mar 6;9(1):3682.

A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomes.
Bertolini I, Terrasi A, Martelli C, Gaudioso G, Di Cristofori A, Storaci AM, Formica M, Braidotti P, Todoerti K, Ferrero S, Caroli M, Ottobrini L, Vaccari T, Vaira V
EBioMedicine. 2019 Feb 5. pii: S2352-3964(19)30059-3. doi: 10.1016/j.ebiom.2019.01.051. [Epub ahead of print]

Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo.
Terrasi A, Bertolini I, Martelli C, Gaudioso G, Di Cristofori A, Storaci AM, Formica M, Bosari S, Caroli M, Ottobrini L, Vaccari T, Vaira V.
EBioMedicine. 2019 Feb 5. pii: S2352-3964(19)30058-1. doi: 10.1016/j.ebiom.2019.01.052. [Epub ahead of print]

NIPBL: a new player in myeloid cells differentiation.
Mazzola M, Deflorian G, Pezzotta A, Ferrari L, Fazio G, Bresciani E, Saitta C, Ferrari L, Fumagalli M, Parma M, Marasca F, Bodega B, Riva P, Cotelli F, Biondi A, Marozzi A, Cazzaniga G, Pistocchi A
Haematologica. 2019 Jan 10. pii: haematol.2018.200899. doi: 10.3324/haematol.2018.200899. [Epub ahead of print]

P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus.
Faliti CE, Gualtierotti R, Rottoli E, Gerosa M, Perruzza L, Romagnani A, Pellegrini G, De Ponte Conti B, Rossi RL, Idzko M, Mazza EMC, Bicciato S, Traggiai E, Meroni PL, Grassi F
J Exp Med. 2019 Jan 17. pii: jem.20171976. doi: 10.1084/jem.20171976. [Epub ahead of print]

ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens.
Proietti M, Perruzza L, Scribano D, Pellegrini G, D’Antuono R, Strati F, Raffaelli M, Gonzalez SF, Thelen M, Hardt WD, Slack E, Nicoletti M, Grassi F.
Nat Commun. 2019 Jan 16;10(1):250.

Eomesodermin controls a unique differentiation program in human IL-10 and IFN-γ co-producing regulatory T-cells.
Gruarin P, Maglie S, De Simone M, Häringer B, Vasco C, Ranzani V, Bosotti R, Noddings JS, Larghi P, Facciotti F, Sarnicola ML, Martinovic M, Crosti MC, Moro M, Rossi RL, Bernardo ME, Caprioli F, Locatelli F, Rossetti G, Abrignani S, Pagani M, Geginat J
Eur J Immunol. 2019 Jan;49(1):96-111.

The Danger Signal Extracellular ATP Is Involved in the Immunomediated Damage of α-Sarcoglycan-Deficient Muscular Dystrophy.

Evaluation of tenascin-C by tenatumomab in T-cell non-Hodgkin lymphomas identifies a new target for radioimmunotherapy.
Gritti G, Gianatti A, Petronzelli F, De Santis R, Pavoni C, Rossi RL, Cattaneo L, Spagnoli LG, Ferrari S, Rossi A, Barbui AM, Rambaldi A.
Oncotarget. (2018) Jan 3;9(11):9766-9775.

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells.

Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease.
Zhang B, Watt JM, Cordiglieri C, Dammermann W, Mahon MF, Flügel A, Guse AH, Potter BVL
Sci Rep. (2018); 13;8(1):16775.

Aspirin Affects Tumor Angiogenesis and Sensitizes Human Glioblastoma Endothelial Cells to Temozolomide, Bevacizumab, and Sunitinib, Impairing Vascular Endothelial Growth Factor-Related Signaling.
Navone SE1 Guarnaccia L, Cordiglieri C, Crisà FM, Caroli M, Locatelli M, Schisano L, Rampini P, Miozzo M, La Verde N, Riboni L, Campanella R, Marfia G.
World Neurosurg. (2018); Aug 23. pii: S1878-8750(18)31863-1.

Angiogenesis in human brain tumors: screening of drug response through a patient-specific cell platform for personalized therapy.
Guarnaccia L, Navone SE, Trombetta E, Cordiglieri C, Cherubini A, Crisà FM, Rampini P, Miozzo M, Fontana L, Caroli M, Locatelli M, Riboni L, Campanella R, Marfia G
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IL-15 regulates susceptibility of CD4+ T cells to HIV infection.
Manganaro L, Hong P, Hernandez MM, Argyle D, Mulder LCF, Potla U, Diaz-Griffero F, Lee B, Fernandez-Sesma A, Simon V.
Proc Natl Acad Sci U S A (2018) 115:E9659-E9667

RACK1 Specifically Regulates Translation through its Binding to Ribosomes.
Gallo S, Ricciardi S, Manfrini N, Pesce E, Oliveto S, Calamita P, Mancino M, Maffioli E, Moro M, Crosti M, Berno V, Bombaci M, Tedeschi G, Biffo S
Mol Cell Biol. (2018) pii: MCB.00230-18. 

Low-affinity Nerve Growth Factor Receptor (CD271) Heterogeneous Expression in Adult and Fetal Mesenchymal Stromal Cells.
Barilani M, Banfi F, Sironi S, Ragni E, Guillaumin S, Polveraccio F, Rosso L, Moro M, Astori G, Pozzobon M, Lazzari L
Sci Rep. (2018); 8(1):9321. 

The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling.
Ricciardi S, Manfrini N, Alfieri R, Calamita P, Crosti MC, Simone G, Müller R, Pagani M, Abrignani S, Biffo S.
Cell Metab. (2018) Aug 29. pii: S1550-4131(18)30510-2.  [Epub ahead of print]

A polysome-based microRNA screen identifies miR-24-3p as a novel pro-migratory miRNA in mesothelioma.
Oliveto S, Alfieri R, Miluzio A, Scagliola A, Seclì RS, Gasparini P, Grosso S, Cascione L, Mutti L, Biffo S.
Cancer Res. (2018) pii: canres.0655.2018 [Epub ahead of print]

A compendium of long non-coding RNAs transcriptional fingerprint in multiple myeloma.
Ronchetti D, Agnelli L, Pietrelli A, Todoerti K, Manzoni M, Taiana E, Neri A.
Sci Rep. 2018 Apr 26;8(1):6557.

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver.
Dongiovanni P, Stender S, Pietrelli A, Mancina RM, Cespiati A, Petta S, Pelusi S, Pingitore P, Badiali S, Maggioni M, Mannisto V, Grimaudo S, Pipitone RM, Pihlajamaki J, Craxi A, Taube M, Carlsson LMS, Fargion S, Romeo S, Kozlitina J1, Valenti L.
J Intern Med. 2018 Apr;283(4):356-370.

Single Cell T Cell Receptor Sequencing: Techniques and Future Challenges.
De Simone M, Rossetti G, Pagani M.
Front Immunol. (2018) 9:1638

Big Data: Challenge and Opportunity for Translational and Industrial Research
Rossi RL, Grifantini RM.
Front. Digit. Humanit. (2018) 5:13. doi: 10.3389/fdigh.2018.00013

Exploring the links between cancer and placenta development
Costanzo V, Bardelli A, Siena S, Abrignani S.
Open Biology (2018) rsob.180081 

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth.
Pacella I, Procaccini C, Focaccetti C, Miacci S, Timperi E, Faicchia D, Severa M, Rizzo F, Coccia EM, Bonacina F, Mitro N, Norata GD, Rossetti G, Ranzani V, Pagani M, Giorda E, Wei Y, Matarese G, Barnaba V, Piconese S.
Proc Natl Acad Sci U S A. (2018) pii: 201720113

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity.
Wang D, Quiros J, Mahuron K, Pai CC, Ranzani V, Young A, Silveria S, Harwin T, Abnousian A, Pagani M, Rosenblum MD, Van Gool F, Fong L, Bluestone JA, DuPage M.
Cell Rep. (2018) 23(11):3262-3274

Elevated TGF β2 serum levels in Emery-Dreifuss Muscular Dystrophy: Implications for myocyte and tenocyte differentiation and fibrogenic processes.
Bernasconi P, Carboni N, Ricci G, Siciliano G, Politano L, Maggi L, Mongini T, Vercelli L, Rodolico C, Biagini E, Boriani G, Ruggiero L, Santoro L, Schena E, Prencipe S, Evangelisti C, Pegoraro E, Morandi L, Columbaro M, Lanzuolo C, Sabatelli P, Cavalcante P, Cappelletti C, Bonne G, Muchir A, Lattanzi G.
Nucleus. (2018) 9(1):292-304.

Mechanical loading of intervertebral disc modulates microglia proliferation, activation, and chemotaxis.
Navone SE, Peroglio M, Guarnaccia L, Beretta M, Grad S, Paroni M, Cordiglieri C, Locatelli M, Pluderi M, Rampini P, Campanella R, Alini M, Marfia G
Osteoarthritis Cartilage. (2018) May 1. pii: S1063-4584(18)31220-2

Mechanotransduction, nuclear architecture and epigenetics in Emery Dreifuss Muscular Dystrophy: tous pour un, un pour tous.
Bianchi A, Manti PG, Lucini F, Lanzuolo C.
Nucleus. (2018) 1;9:276-290

A Mad2-Mediated Translational Regulatory Mechanism Promoting S-Phase Cyclin Synthesis Controls Origin Firing and Survival to Replication Stress.
Gay S, Piccini D, Bruhn C, Ricciardi S, Soffientini P, Carotenuto W, Biffo S, Foiani M.
Mol Cell. (2018) 70(4):628-638

Magnetically driven drug delivery systems improving targeted immunotherapy for colon-rectal cancer.
Grifantini R, Taranta M, Gherardini L, Naldi I, Parri M, Grandi A, Giannetti A, Tombelli S, Lucarini G, Ricotti L, Campagnoli S, De Camilli E, Pelosi G, Baldini F, Menciassi A, Viale G, Pileri P, Cinti C.
J Control Release (2018) pii: S0168-3659(18)30254-2

Enhancer reprogramming in tumor progression: a new route towards cancer cell plasticity.
Fagnocchi L, Poli V, Zippo A.
Cell Mol Life Science (2018) s00018-018-2820-1

Pathogenicity of in-vivo generated intestinal Th17 lymphocytes is IFNγ dependent.
Nizzoli G, Burrello C, Cribiù FM, Lovati G, Ercoli G, Botti F, Trombetta E, Porretti L, Todoerti K, Neri A, Giuffrè MR, Geginat J, Vecchi M, Rescigno M, Paroni M, Caprioli F, Facciotti F.
J Crohns Colitis (2018) ecco-jcc/jjy051 

Dynamic and Cell-Specific DACH1 Expression in Human Neocortical and Striatal Development.
Castiglioni V, Faedo A, Onorati M, Bocchi VD, Li Z, Iennaco R, Vuono R, Bulfamante GP, Muzio L, Martino G, Sestan N, Barker RA, Cattaneo E.
Cerebral Cortex (2018) cercor/bhy092 

Sumoylation and ubiquitylation crosstalk in the control of ΔNp63α protein stability.
Ranieri M, Vivo M, De Simone M, Guerrini L, Pollice A, La Mantia G, Calabrò V.
Gene (2018) 645:34-40

Enhancing Antibody Serodiagnosis Using a Controlled Peptide Coimmobilization Strategy.
Sola L, Gagni P, D’Annessa I, Capelli R, Bertino C, Romanato A, Damin F, Bergamaschi G, Marchisio E, Cuzzocrea A, Bombaci M, Grifantini R, Chiari M, Colombo G, Gori A, Cretich M.
ACS Infect Dis (2018) 8b00014

How Polycomb-Mediated Cell Memory Deals With a Changing Environment: Variations in PcG complexes and proteins assortment convey plasticity to epigenetic regulation as a response to environment.
Marasca F, Bodega B, Orlando V.
Bioessays. (2018) 40(4):e1700137

Modulation of innate and adaptive immunity by P2X ion channels.
Di Virgilio F, Sarti AC, Grassi F.
Curr Opin Immunol. (2018) 52:51-59 [Epub ahead of print]

Successful sequential therapy with rituximab and belimumab in patients with active systemic lupus erythematosus: a case series.
Gualtierotti R, Borghi MO, Gerosa M, Schioppo T, Larghi P, Geginat J, Meroni PL
Clin Exp Rheumatol. (2018) Feb 27. [Epub ahead of print]

MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state.
Poli V, Fagnocchi L, Fasciani A, Cherubini A, Mazzoleni S, Ferrillo S, Miluzio A, Gaudioso G, Vaira V, Turdo A, Giaggianesi M, Chinnici A, Lipari E, Bicciato S, Bosari S, Todaro M, Zippo A.
Nat Commun. (2018) 9(1):1024.

Intestinal IFN-γ-producing Tr1-cells co-express CCR5 and PD-1, and down-regulate IL-10 in the inflamed gut of IBD patients.
Alfen JS, Larghi P, Facciotti F, Gagliani N, Bosotti R, Paroni M, Maglie S, Gruarin P, Vasco CM, Ranzani V, Frusteri C, Iseppon A, Moro M, Crosti MC, Gatti S, Pagani M, Caprioli F, Abrignani S, Flavell RA, Geginat J.
J Allergy Clin Immunol (2018) [Epub ahead of print]

Lack of Methyl-CpG Binding Protein 2 (MeCP2) Affects Cell Fate Refinement During Embryonic Cortical Development.
Cobolli Gigli C, Scaramuzza L, De Simone M, Rossi RL, Pozzi D, Pagani M, Landsberger N, Bedogni F.
Cereb Cortex. (2018) [Epub ahead of print]

Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes.
Conforti P, Besusso D, Bocchia VD,  Faedo A, Cesana E, Rossetti G, Ranzani V,  Svendsend CN, Thompson LM, Toselli M, Biella G, Pagani M, Cattaneo E.
Proc Natl Acad Sci U S A. (2018) 115(4):E762-E771

myVCF: a desktop application for high-throughput mutations data management.
Pietrelli A, Valenti L.
Bioinformatics (2017). 33(22):3676-3678.

TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut.
Romagnani A, Vettore V, Rezzonico-Jost T, Hampe S, Rottoli E, Nadolni W, Perotti M, Meier MA, Hermanns C, Geiger S, Wennemuth G, Recordati C, Matsushita M, Muehlich S, Proietti M, Chubanov V, Gudermann T, Grassi F, Zierler S.
Nat Commun. (2017). 8(1):1917.

TCTN2: a novel tumor marker with oncogenic properties.
Cano-Rodriguez D, Campagnoli S, Grandi A, Parri M, Camilli E, Song C, Jin B, Lacombe A, Pierleoni A, Bombaci M, Cordiglieri C, Ruiters MH, Viale G, Terracciano L, Sarmientos P, Abrignani S, Grandi G, Pileri P, Rots MG, Grifantini R.
Oncotarget. (2017).8(56):95256-95269.

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation.
Cariulo C, Azzollini L, Verani M, Martufi P, Boggio R, Chiki A, Deguire SM, Cherubini M, Gines S, Marsh JL, Conforti P, Cattaneo E, Santimone I, Squitieri F, Lashuel HA, Petricca L, Caricasole A
Proc Natl Acad Sci U S A. (2017). 114(50):E10809-E10818.

Crosstalks between translation and metabolism in cancer.
Biffo S, Manfrini N, Ricciardi S.
Curr Opin Genet Dev. (2017) 48:75-81.

FGF2 and EGF Are Required for Self-Renewal and Organoid Formation of Canine Normal and Tumor Breast Stem Cells.

Cocola C, Molgora S, Piscitelli E, Veronesi MC, Greco M, Bragato C, Moro M, Crosti M, Gray B, Milanesi L, Grieco V, Luvoni GC, Kehler J, Bellipanni G, Reinbold R, Zucchi I, Giordano A
J Cell Biochem. (2017); 118:570-584.

The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks.
Clarke K, Ricciardi S, Pearson T, Bharudin I, Davidsen PK, Bonomo M, Brina D, Scagliola A, Simpson DM, Beynon RJ, Khanim F, Ankers J, Sarzynski MA, Ghosh S, Pisconti A, Rozman J, Hrabe de Angelis M, Bunce C, Stewart C, Egginton S, Caddick M, Jackson M, Bouchard C, Biffo S, Falciani F
Cell Rep. (2017) 21:1507-1520.

Guidelines for the use of flow cytometry and cell sorting in immunological studies.
Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O’Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J.
Eur J Immunol (2017) 47:1584-1797

Repression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells.
Ripamonti A, Provasi E, Lorenzo M, De Simone M, Ranzani V, Vangelisti S, Curti S, Bonnal RJP, Pignataro L, Torretta S, Geginat J, Rossetti G, Pagani M, Abrignani S.
Proc Natl Acad Sci U S A. (2017) 114:12797-12802

Maintenance of memory CD8 T cells: Divided over division.
Nolte MA, Goedhart M, Geginat J.
Eur J Immunol. (2017) 47:1875-1879

CD4+ T Helper Cell Plasticity in Infection, Inflammation, and Autoimmunity.
Huber S, Gagliani N, O’Connor W Jr, Geginat J, Caprioli F.
Mediators Inflamm. 2017;2017:7083153

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.
Benzine T, Brandt R, Lovell WC, Yamane D, Neddermann P, De Francesco R, Lemon SM, Perelson AS, Ke R, McGivern DR.
PLoS Pathog (2017) 13:e1006343

A cytosolic Ezh1 isoform modulates a PRC2-Ezh1 epigenetic adaptive response in postmitotic cells.
Bodega B, Marasca F, Ranzani V, Cherubini A, Della Valle F, Neguembor MV, Wassef M, Zippo A, Lanzuolo C, Pagani M, Orlando V.
Nat Struct Mol Biol (2017) 24:444-452

SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention.
Calamita P, Miluzio A, Russo A, Pesce E, Ricciardi S, Khanim F, Cheroni C, Alfieri R, Mancino M, Gorrini C, Rossetti G, Peluso I, Pagani M, Medina DL, Rommens J, Biffo S.
PLoS Genet (2017) 13:e1006552

Improvement of ALT decay kinetics by all-oral HCV treatment: Role of NS5A inhibitors and differences with IFN-based regimens.
Cento V, Nguyen THT, Di Carlo D, Biliotti E, Gianserra L, Lenci I, Di Paolo D, Calvaruso V, Teti E, Cerrone M, Romagnoli D, Melis M, Danieli E, Menzaghi B, Polilli E, Siciliano M, Nicolini LA, Di Biagio A, Magni CF, Bolis M, Antonucci FP, Di Maio VC, Alfieri R, Sarmati L, Casalino P, Bernardini S, Micheli V, Rizzardini G, Parruti G, Quirino T, Puoti M, Babudieri S, D’Arminio Monforte A, Andreoni M, Craxi A, Angelico M, Pasquazzi C, Taliani G, Guedj J, Perno CF, Ceccherini-Silberstein F.
PLoS One (2017) 12:e0177352

Eukaryotic initiation factor eIF6 modulates the expression of Kermit 2/XGIPC in IGF- regulated eye development.
De Marco N, Tussellino M, Carotenuto R, Ronca R, Rizzolio S, Biffo S, Campanella C.
Dev Biol (2017) 427:148-154

Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease.
Donati B, Pietrelli A, Pingitore P, Dongiovanni P, Caddeo A, Walker L, Baselli G, Pelusi S, Rosso C, Vanni E, Daly A, Mancina RM, Grieco A, Miele L, Grimaudo S, Craxi A, Petta S, De Luca L, Maier S, Soardo G, Bugianesi E, Colli F, Romagnoli R, Anstee QM, Reeves HL, Fracanzani AL, Fargion S, Romeo S, Valenti L.
Cancer Med (2017) 6:1930-1940

Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
Dongiovanni P, Meroni M, Baselli GA, Bassani GA, Rametta R, Pietrelli A, Maggioni M, Facciotti F, Trunzo V, Badiali S, Fargion S, Gatti S, Valenti L.
Clin Sci (Lond) (2017) 131:1301-1315

Differentiation of human telencephalic progenitor cells into MSNs by inducible expression of Gsx2 and Ebf1.
Faedo A, Laporta A, Segnali A, Galimberti M, Besusso D, Cesana E, Belloli S, Moresco RM, Tropiano M, Fuca E, Wild S, Bosio A, Vercelli AE, Biella G, Cattaneo E.
Proc Natl Acad Sci U S A (2017) 114:E1234-E1242

Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells.
Fagnocchi L, Zippo A.
Front Cell Dev Biol (2017) 5:7

MicroRNA-26a/cyclin-dependent kinase 5 axis controls proliferation, apoptosis and in vivo tumor growth of diffuse large B-cell lymphoma cell lines.
Farina FM, Inguscio A, Kunderfranco P, Cortesi A, Elia L, Quintavalle M.
Cell Death Dis (2017) 8:e2890

Lack of evidence for post-vaccine onset of autoimmune/lymphoproliferative disorders, during a nine-month follow-up in multiply vaccinated Italian military personnel.
Ferlito C, Barnaba V, Abrignani S, Bombaci M, Sette A, Sidney J, Biselli R, Tomao E, Cattaruzza MS, Germano V, Biondo MI, Salerno G, Lulli P, Caporuscio S, Picchianti Diamanti A, Falco M, Biselli V, Cardelli P, Autore A, Lucertini E, De Cesare DP, Peragallo MS, Lista F, Martire C, Salemi S, Nisini R, D’Amelio R.
Clin Immunol (2017) 181:60-66

Immunological phenotype of the murine Lrba knockout.
Gamez-Diaz L, Neumann J, Jager F, Proietti M, Felber F, Soulas-Sprauel P, Perruzza L, Grassi F, Kogl T, Aichele P, Kilimann M, Grimbacher B, Jung S.
Immunol Cell Biol (2017) 95:789-802

The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?
Geginat J, Paroni M, Pagani M, Galimberti D, De Francesco R, Scarpini E, Abrignani S.
Trends Immunol (2017) 38:498-512

Purification of LAT-Containing Membranes from Resting and Activated T Lymphocytes.
Hivroz C, Larghi P, Jouve M, Ardouin L.
Methods Mol Biol (2017) 1584:355-368

The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets.
Iaconis D, Monti M, Renda M, van Koppen A, Tammaro R, Chiaravalli M, Cozzolino F, Pignata P, Crina C, Pucci P, Boletta A, Belcastro V, Giles RH, Surace EM, Gallo S, Pende M, Franco B.
Sci Rep (2017) 7:1224

Analysis of T Cell Activation by Confocal Microscopy.
Larghi P, Viola A, Molon B.
Methods Mol Biol (2017) 1514:63-81

Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation.
Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Adler T, Busch DH, Gailus-Durner V, Fuchs H, de Angelis MH, Biffo S.
Data Brief (2017) 14:653-658

High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans.
Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Brina D, Adler T, Busch DH, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Biffo S.
Dev Comp Immunol (2017) 77:69-76

CombiROC: an interactive web tool for selecting accurate marker combinations of omics data.
Mazzara S, Rossi RL, Grifantini R, Donizetti S, Abrignani S, Bombaci M.
Sci Rep (2017) 7:45477

Filamin A is reduced and contributes to the CASR sensitivity in human parathyroid tumors.
Mingione A, Verdelli C, Ferrero S, Vaira V, Guarnieri V, Scillitani A, Vicentini L, Balza G, Beretta E, Terranegra A, Vezzoli G, Soldati L, Corbetta S.
J Mol Endocrinol (2017) 58:91-103

Role of microRNAs in translation regulation and cancer.
Oliveto S, Mancino M, Manfrini N, Biffo S.
World J Biol Chem (2017) 8:45-56

Recognition of viral and self-antigens by TH1 and TH1/TH17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and relapses.
Paroni M, Maltese V, De Simone M, Ranzani V, Larghi P, Fenoglio C, Pietroboni AM, De Riz MA, Crosti MC, Maglie S, Moro M, Caprioli F, Rossi R, Rossetti G, Galimberti D, Pagani M, Scarpini E, Abrignani S, Geginat J.
J Allergy Clin Immunol (2017) 140:797-808

Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis.
Penatti A, Facciotti F, De Matteis R, Larghi P, Paroni M, Murgo A, De Lucia O, Pagani M, Pierannunzii L, Truzzi M, Ioan-Facsinay A, Abrignani S, Geginat J, Meroni PL.
Arthritis Res Ther (2017) 19:103

T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP.
Perruzza L, Gargari G, Proietti M, Fosso B, D’Erchia AM, Faliti CE, Rezzonico-Jost T, Scribano D, Mauri L, Colombo D, Pellegrini G, Moregola A, Mooser C, Pesole G, Nicoletti M, Norata GD, Geuking MB, McCoy KD, Guglielmetti S, Grassi F.
Cell Rep (2017) 18:2566-2575

Dopamine receptor type 2 (DRD2) and somatostatin receptor type 2 (SSTR2) agonists are effective in inhibiting proliferation of progenitor/stem-like cells isolated from nonfunctioning pituitary tumors.
Peverelli E, Giardino E, Treppiedi D, Meregalli M, Belicchi M, Vaira V, Corbetta S, Verdelli C, Verrua E, Serban AL, Locatelli M, Carrabba G, Gaudenzi G, Malchiodi E, Cassinelli L, Lania AG, Ferrero S, Bosari S, Vitale G, Torrente Y, Spada A, Mantovani G.
Int J Cancer (2017) 140:1870-1880

Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression.
Poli A, Fiume R, Baldanzi G, Capello D, Ratti S, Gesi M, Manzoli L, Graziani A, Suh PG, Cocco L, Follo MY.
J Cell Physiol (2017) 232:2550-2557

Nuclear translocation of PKC-alpha is associated with cell cycle arrest and erythroid differentiation in myelodysplastic syndromes (MDSs).
Poli A, Ratti S, Finelli C, Mongiorgi S, Clissa C, Lonetti A, Cappellini A, Catozzi A, Barraco M, Suh PG, Manzoli L, McCubrey JA, Cocco L, Follo MY.
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Next-Generation Sequencing Analysis of Long Noncoding RNAs in CD4+ T Cell Differentiation.
Ranzani V, Arrigoni A, Rossetti G, Panzeri I, Abrignani S, Bonnal RJ, Pagani M.
Methods Mol Biol (2017) 1514:173-185

Human macrophage ferroportin biology and the basis for the ferroportin disease.
Sabelli M, Montosi G, Garuti C, Caleffi A, Oliveto S, Biffo S, Pietrangelo A.
Hepatology (2017) 65:1512-1525

Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity.
Torri A, Carpi D, Bulgheroni E, Crosti MC, Moro M, Gruarin P, Rossi RL, Rossetti G, Di Vizio D, Hoxha M, Bollati V, Gagliani C, Tacchetti C, Paroni M, Geginat J, Corti L, Venegoni L, Berti E, Pagani M, Matarese G, Abrignani S, de Candia P.
J Biol Chem (2017) 292:2903-2915

Extracellular Vesicle-Shuttled mRNA in Mesenchymal Stem Cell Communication.
Ragni E, Banfi F, Barilani M, Cherubini A, Parazzi V, Larghi P, Dolo V, Bollati V, Lazzari L.
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Genomic and transcriptomic comparison between Staphylococcus aureus strains associated with high and low within herd prevalence of intra-mammary infection.
Capra E, Cremonesi P, Pietrelli A, Puccio S, Luini M, Stella A, Castiglioni B.
BMC Microbiol. (2017) Jan 19;17(1):21.

Successful Treatment With Vedolizumab in a Patient With Chronic Refractory Pouchitis and Primary Sclerosing Cholangitis.
Coletta M, Paroni M, Caprioli F.
J Crohns Colitis. 2017 Dec 4;11(12):1507-1508.

Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease.
Donati B, Pietrelli A, Pingitore P, Dongiovanni P, Caddeo A, Walker L, Baselli G, Pelusi S, Rosso C, Vanni E, Daly A, Mancina RM, Grieco A, Miele L, Grimaudo S, Craxi A, Petta S, De Luca L, Maier S, Soardo G, Bugianesi E, Colli F, Romagnoli R, Anstee QM, Reeves HL, Fracanzani AL, Fargion S, Romeo S, Valenti L.
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MiRNA-210: A Current Overview.
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Immunological phenotype of the murine Lrba knockout.
Gámez-Díaz L, Neumann J, Jäger F, Proietti M, Felber F, Soulas-Sprauel P, Perruzza L, Grassi F, Kögl T, Aichele P, Kilimann M, Grimbacher B, Jung S.
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miR-17∼92 family clusters control iNKT cell ontogenesis via modulation of TGF-β signaling.
Fedeli M, Riba M, Garcia Manteiga JM, Tian L, Viganò V, Rossetti G, Pagani M, Xiao C, Liston A, Stupka E, Cittaro D, Abrignani S, Provero P, Dellabona P, Casorati G
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The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery.
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Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.
Bedogni F, Cobolli Gigli C, Pozzi D, Rossi RL, Scaramuzza L, Rossetti G, Pagani M, Kilstrup-Nielsen C, Matteoli M, Landsberger N.
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In-Vivo Validation of Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism.
Baj-Rossi C, Cavallini A, Kilinc EG, Stradolini F, Rezzonico Jost T, Proietti M, De Micheli G, Grassi F, Dehollain C, Carrara S.
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Determination of Polycomb Group of Protein Compartmentalization Through Chromatin Fractionation Procedure.
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Analysis RNA-seq and Noncoding RNA.
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FALDO: a semantic standard for describing the location of nucleotide and protein feature annotation.
Bolleman JT, Mungall CJ, Strozzi F, Baran J, Dumontier M, Bonnal RJ, Buels R, Hoehndorf R, Fujisawa T, Katayama T, Cock PJ.
J Biomed Semantics (2016) 7:39

DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection.
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Hepatology (2016) 63:418-27

A neuronal network of mitochondrial dynamics regulates metastasis.
Caino MC, Seo JH, Aguinaldo A, Wait E, Bryant KG, Kossenkov AV, Hayden JE, Vaira V, Morotti A, Ferrero S, Bosari S, Gabrilovich DI, Languino LR, Cohen AR, Altieri DC.
Nat Commun (2016) 7:13730

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.
Chae YC, Vaira V, Caino MC, Tang HY, Seo JH, Kossenkov AV, Ottobrini L, Martelli C, Lucignani G, Bertolini I, Locatelli M, Bryant KG, Ghosh JC, Lisanti S, Ku B, Bosari S, Languino LR, Speicher DW, Altieri DC.
Cancer Cell (2016) 30:257-272

Fluorescence Resonance Energy Transfer Microscopy for Measuring Chromatin Complex Structure and Dynamics.
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Methods Mol Biol (2016) 1480:143-52

The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells.
Chiaruttini G, Piperno GM, Jouve M, De Nardi F, Larghi P, Peden AA, Baj G, Muller S, Valitutti S, Galli T, Benvenuti F.
Cell Rep (2016) 14:2624-36

Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer.
Ciardiello C, Cavallini L, Spinelli C, Yang J, Reis-Sobreiro M, de Candia P, Minciacchi VR, Di Vizio D.
Int J Mol Sci (2016) 17:175

Chromosome Conformation Capture in Primary Human Cells.
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The circulating microRNome demonstrates distinct lymphocyte subset-dependent signatures.
de Candia P, Torri A, Fedeli M, Vigano V, Carpi D, Gorletta T, Casorati G, Pagani M, Dellabona P, Abrignani S.
Eur J Immunol (2016) 46:725-31

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells.
De Simone M, Arrigoni A, Rossetti G, Gruarin P, Ranzani V, Politano C, Bonnal RJ, Provasi E, Sarnicola ML, Panzeri I, Moro M, Crosti M, Mazzara S, Vaira V, Bosari S, Palleschi A, Santambrogio L, Bovo G, Zucchini N, Totis M, Gianotti L, Cesana G, Perego RA, Maroni N, Pisani Ceretti A, Opocher E, De Francesco R, Geginat J, Stunnenberg HG, Abrignani S, Pagani M.
Immunity (2016) 45:1135-1147

Analysis of NSCLC tumour heterogeneity, proliferative and 18F-FDG PET indices reveals Ki67 prognostic role in adenocarcinomas.
Del Gobbo A, Pellegrinelli A, Gaudioso G, Castellani M, Zito Marino F, Franco R, Palleschi A, Nosotti M, Bosari S, Vaira V, Ferrero S.
Histopathology (2016) 68:746-51

Phosphoinositides in the nucleus and myogenic differentiation: how a nuclear turtle with a PHD builds muscle.
Divecha N.
Biochem Soc Trans (2016) 44:299-306

The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage.
Donati B, Motta BM, Pingitore P, Meroni M, Pietrelli A, Alisi A, Petta S, Xing C, Dongiovanni P, del Menico B, Rametta R, Mancina RM, Badiali S, Fracanzani AL, Craxi A, Fargion S, Nobili V, Romeo S, Valenti L.
Hepatology (2016) 63:787-98

Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIalpha and Oxysterol-Binding Protein.
Dorobantu CM, Albulescu L, Lyoo H, van Kampen M, De Francesco R, Lohmann V, Harak C, van der Schaar HM, Strating JR, Gorbalenya AE, van Kuppeveld FJ.
mSphere (2016) 1

IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus.
Facciotti F, Gagliani N, Haringer B, Alfen JS, Penatti A, Maglie S, Paroni M, Iseppon A, Moro M, Crosti MC, Stolzel K, Romagnani C, Moroni G, Ingegnoli F, Torretta S, Pignataro L, Annoni A, Russo F, Pagani M, Abrignani S, Meroni P, Flavell R, Geginat J.
J Allergy Clin Immunol (2016) 137:318-321 e5

A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity.
Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, Berno V, Rossi RL, Reinbold R, Endele M, Schroeder T, Rocchigiani M, Szkarlat Z, Oliviero S, Dalton S, Zippo A.
Nat Commun (2016) 7:11903

Integration of Signaling Pathways with the Epigenetic Machinery in the Maintenance of Stem Cells.
Fagnocchi L, Mazzoleni S, Zippo A.
Stem Cells Int (2016) 2016:8652748

Ectonucleotidase activity and immunosuppression in astrocyte-CD4 T cell bidirectional signaling.
Filipello F, Pozzi D, Proietti M, Romagnani A, Mazzitelli S, Matteoli M, Verderio C, Grassi F.
Oncotarget (2016) 7:5143-56

PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis.
Fiume R, Jones DR, Divecha N.
Trends Biochem Sci (2016) 41:473-475

The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer.
Geginat J, Larghi P, Paroni M, Nizzoli G, Penatti A, Pagani M, Gagliani N, Meroni P, Abrignani S, Flavell RA.
Cytokine Growth Factor Rev (2016) 30:87-93

Reverse plasticity: TGF-beta and IL-6 induce Th1-to-Th17-cell transdifferentiation in the gut.
Geginat J, Paroni M, Kastirr I, Larghi P, Pagani M, Abrignani S.
Eur J Immunol (2016) 46:2306-2310

ERMP1, a novel potential oncogene involved in UPR and oxidative stress defense, is highly expressed in human cancer.
Grandi A, Santi A, Campagnoli S, Parri M, De Camilli E, Song C, Jin B, Lacombe A, Castori-Eppenberger S, Sarmientos P, Grandi G, Viale G, Terracciano L, Chiarugi P, Pileri P, Grifantini R.
Oncotarget (2016) 7:63596-63610

An Automatic Segmentation Method Combining an Active Contour Model and a Classification Technique for Detecting Polycomb-group Proteinsin High-Throughput Microscopy Images.
Gregoretti F, Cesarini E, Lanzuolo C, Oliva G, Antonelli L.
Methods Mol Biol (2016) 1480:181-97

Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.
Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Vondran FW, De Francesco R, Rice CM, Bartenschlager R, Lohmann V.
Nat Microbiol (2016) 2:16247

Role of CXCR4-mediated bone marrow colonization in CNS infiltration by T cell acute lymphoblastic leukemia.
Jost TR, Borga C, Radaelli E, Romagnani A, Perruzza L, Omodho L, Cazzaniga G, Biondi A, Indraccolo S, Thelen M, Te Kronnie G, Grassi F.
J Leukoc Biol (2016) 99:1077-87

Platelet-derived growth factor-alpha receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer.
Kabanova A, Marcandalli J, Zhou T, Bianchi S, Baxa U, Tsybovsky Y, Lilleri D, Silacci-Fregni C, Foglierini M, Fernandez-Rodriguez BM, Druz A, Zhang B, Geiger R, Pagani M, Sallusto F, Kwong PD, Corti D, Lanzavecchia A, Perez L.
Nat Microbiol (2016) 1:16082

Normalization of circulating microRNA expression data obtained by quantitative real-time RT-PCR.
Marabita F, de Candia P, Torri A, Tegner J, Abrignani S, Rossi RL.
Brief Bioinform (2016) 17:204-12

The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling.
Marfia G, Navone SE, Hadi LA, Paroni M, Berno V, Beretta M, Gualtierotti R, Ingegnoli F, Levi V, Miozzo M, Geginat J, Fassina L, Rampini P, Tremolada C, Riboni L, Campanella R.
Stem Cells Dev (2016) 25:1095-107

Nucleoplasmic Lamin A/C and Polycomb group of proteins: An evolutionarily conserved interplay.
Marullo F, Cesarini E, Antonelli L, Gregoretti F, Oliva G, Lanzuolo C.
Nucleus (2016) 7:103-11

Translational control by mTOR-independent routes: how eIF6 organizes metabolism.
Miluzio A, Ricciardi S, Manfrini N, Alfieri R, Oliveto S, Brina D, Biffo S.
Biochem Soc Trans (2016) 44:1667-1673

CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization.
Nawaz MS, Giarda E, Bedogni F, La Montanara P, Ricciardi S, Ciceri D, Alberio T, Landsberger N, Rusconi L, Kilstrup-Nielsen C.
PLoS One (2016) 11:e0148634

IL-10 promotes homeostatic proliferation of human CD8(+) memory T cells and, when produced by CD1c(+) DCs, shapes naive CD8(+) T-cell priming.
Nizzoli G, Larghi P, Paroni M, Crosti MC, Moro M, Neddermann P, Caprioli F, Pagani M, De Francesco R, Abrignani S, Geginat J.
Eur J Immunol (2016) 46:1622-32

Uncontrolled IL-17 Production by Intraepithelial Lymphocytes in a Case of non-IPEX Autoimmune Enteropathy.
Paroni M, Magarotto A, Tartari S, Nizzoli G, Larghi P, Ercoli G, Gianelli U, Pagani M, Elli L, Abrignani S, Conte D, Geginat J, Caprioli F.
Clin Transl Gastroenterol (2016) 7:e182

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.
Pema M, Drusian L, Chiaravalli M, Castelli M, Yao Q, Ricciardi S, Somlo S, Qian F, Biffo S, Boletta A.
Nat Commun (2016) 7:10786

Dopamine receptor type 2 (DRD2) inhibits migration and invasion of human tumorous pituitary cells through ROCK-mediated cofilin inactivation.
Peverelli E, Giardino E, Treppiedi D, Locatelli M, Vaira V, Ferrero S, Bosari S, Lania AG, Spada A, Mantovani G.
Cancer Lett (2016) 381:279-86

Role of Strain Rate in the Pathogenesis of Ventilator-Induced Lung Edema.
Protti A, Maraffi T, Milesi M, Votta E, Santini A, Pugni P, Andreis DT, Nicosia F, Zannin E, Gatti S, Vaira V, Ferrero S, Gattinoni L
Crit Care Med (2016) 44:e838-45

Protein O-mannosylation is crucial for human mesencyhmal stem cells fate.
Ragni E, Lommel M, Moro M, Crosti M, Lavazza C, Parazzi V, Saredi S, Strahl S, Lazzari L.
Cell Mol Life Sci (2016) 73:445-58

Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects.
Rigoni R, Fontana E, Guglielmetti S, Fosso B, D’Erchia AM, Maina V, Taverniti V, Castiello MC, Mantero S, Pacchiana G, Musio S, Pedotti R, Selmi C, Mora JR, Pesole G, Vezzoni P, Poliani PL, Grassi F, Villa A, Cassani B.
J Exp Med (2016) 213:355-75

RAGs and BUGS: An alliance for autoimmunity.
Rigoni R, Grassi F, Villa A, Cassani B.
Gut Microbes (2016) 7:503-511

Sirolimus Therapy for Patients With Lymphangioleiomyomatosis Leads to Loss of Chylous Ascites and Circulating LAM Cells.
Harari S, Elia D, Torre O, Bulgheroni E, Provasi E, Moss J
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Daclatasvir: a team player rather than a prima donna in the treatment of hepatitis C.
Aghemo A, De Francesco R.
Gut (2015) 64:860-2

Dissection of the cord blood stromal component reveals predictive parameters for culture outcome.
Barilani M, Lavazza C, Vigano M, Montemurro T, Boldrin V, Parazzi V, Montelatici E, Crosti M, Moro M, Giordano R, Lazzari L.
Stem Cells Dev (2015) 24:104-14

G-Force PD: a global initiative in coordinating stem cell-based dopamine treatments for Parkinson’s disease.
Barker RA, Studer L, Cattaneo E, Takahashi J, consortium GFP.
NPJ Parkinsons Dis (2015) 1:15017

De novo transcriptome profiling of highly purified human lymphocytes primary cells.
Bonnal RJ, Ranzani V, Arrigoni A, Curti S, Panzeri I, Gruarin P, Abrignani S, Rossetti G, Pagani M.
Sci Data (2015) 2:150051

miRiadne: a web tool for consistent integration of miRNA nomenclature.
Bonnal RJ, Rossi RL, Carpi D, Ranzani V, Abrignani S, Pagani M.
Nucleic Acids Res (2015) 43:W487-92

eIF6 anti-association activity is required for ribosome biogenesis, translational control and tumor progression.
Brina D, Miluzio A, Ricciardi S, Biffo S.
Biochim Biophys Acta (2015) 1849:830-5

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.
Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen PK, Viero G, Tebaldi T, Offenhauser N, Rozman J, Rathkolb B, Neschen S, Klingenspor M, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Quattrone A, Falciani F, Biffo S.
Nat Commun (2015) 6:8261

Gaps in knowledge and prospects for research of adjuvanted vaccines.
Seder R, Reed SG, O’Hagan D, Malyala P, D’Oro U, Laera D, Abrignani S, Cerundolo V, Steinman L, Bertholet S
Vaccine (2015) 33 Suppl 2:B40-3

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.
Caino MC, Ghosh JC, Chae YC, Vaira V, Rivadeneira DB, Faversani A, Rampini P, Kossenkov AV, Aird KM, Zhang R, Webster MR, Weeraratna AT, Bosari S, Languino LR, Altieri DC.
Proc Natl Acad Sci U S A (2015) 112:8638-43

Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes.
Cesarini E, Mozzetta C, Marullo F, Gregoretti F, Gargiulo A, Columbaro M, Cortesi A, Antonelli L, Di Pelino S, Squarzoni S, Palacios D, Zippo A, Bodega B, Oliva G, Lanzuolo C.
J Cell Biol (2015) 211:533-51

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.
Cheroni C, Donnici L, Aghemo A, Balistreri F, Bianco A, Zanoni V, Pagani M, Soffredini R, D’Ambrosio R, Rumi MG, Colombo M, Abrignani S, Neddermann P, De Francesco R.
PLoS One (2015) 10:e0138546

Systematic comparison of single-chain Fv antibody-fusion toxin constructs containing Pseudomonas Exotoxin A or saporin produced in different microbial expression systems.
Della Cristina P, Castagna M, Lombardi A, Barison E, Tagliabue G, Ceriotti A, Koutris I, Di Leandro L, Giansanti F, Vago R, Ippoliti R, Flavell SU, Flavell DJ, Colombatti M, Fabbrini MS.
Microb Cell Fact (2015) 14:19

The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.
Di Cristofori A, Ferrero S, Bertolini I, Gaudioso G, Russo MV, Berno V, Vanini M, Locatelli M, Zavanone M, Rampini P, Vaccari T, Caroli M, Vaira V.
Oncotarget (2015) 6:17514-31

The calcineurin-NFAT pathway controls activity-dependent circadian gene expression in slow skeletal muscle.
Dyar KA, Ciciliot S, Tagliazucchi GM, Pallafacchina G, Tothova J, Argentini C, Agatea L, Abraham R, Ahdesmaki M, Forcato M, Bicciato S, Schiaffino S, Blaauw B.
Mol Metab (2015) 4:823-33

Deregulation of MiR-34b/Sox2 Predicts Prostate Cancer Progression.
Forno I, Ferrero S, Russo MV, Gazzano G, Giangiobbe S, Montanari E, Del Nero A, Rocco B, Albo G, Languino LR, Altieri DC, Vaira V, Bosari S.
PLoS One (2015) 10:e0130060

The Contrasting Role of p16Ink4A Patterns of Expression in Neuroendocrine and Non-Neuroendocrine Lung Tumors: A Comprehensive Analysis with Clinicopathologic and Molecular Correlations.
Fusco N, Guerini-Rocco E, Del Gobbo A, Franco R, Zito-Marino F, Vaira V, Bulfamante G, Ercoli G, Nosotti M, Palleschi A, Bosari S, Ferrero S.
PLoS One (2015) 10:e0144923

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
Gagliani N, Amezcua Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limon P, Paiva RS, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire LX, Cotton MJ, Drier Y, Bernstein B, Geginat J, Stockinger B, Esplugues E, Huber S, Flavell RA.
Nature (2015) 523:221-5

Working hard at the nexus between cell signaling and the ribosomal machinery: An insight into the roles of RACK1 in translational regulation.
Gallo S, Manfrini N.
Translation (Austin) (2015) 3:e1120382

Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets.
Geginat J, Nizzoli G, Paroni M, Maglie S, Larghi P, Pascolo S, Abrignani S.
Front Immunol (2015) 6:527

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.
Ghosh JC, Siegelin MD, Vaira V, Faversani A, Tavecchio M, Chae YC, Lisanti S, Rampini P, Giroda M, Caino MC, Seo JH, Kossenkov AV, Michalek RD, Schultz DC, Bosari S, Languino LR, Altieri DC.
J Natl Cancer Inst (2015) 107

Signal Strength and Metabolic Requirements Control Cytokine-Induced Th17 Differentiation of Uncommitted Human T Cells.
Kastirr I, Crosti M, Maglie S, Paroni M, Steckel B, Moro M, Pagani M, Abrignani S, Geginat J.
J Immunol (2015) 195:3617-27

Two of Them Do It Better: Novel Serum Biomarkers Improve Autoimmune Hepatitis Diagnosis.
Mazzara S, Sinisi A, Cardaci A, Rossi RL, Muratori L, Abrignani S, Bombaci M.
PLoS One (2015) 10:e0137927

Transmembrane 6 superfamily member 2 gene E167K variant impacts on steatosis and liver damage in chronic hepatitis C patients.
Milano M, Aghemo A, Mancina RM, Fischer J, Dongiovanni P, De Nicola S, Fracanzani AL, D’Ambrosio R, Maggioni M, De Francesco R, Fargion S, Berg T, Stickel F, Hampe J, Romeo S, Colombo M, Valenti L.
Hepatology (2015) 62:111-7

Expression and activity of eIF6 trigger malignant pleural mesothelioma growth in vivo.
Miluzio A, Oliveto S, Pesce E, Mutti L, Murer B, Grosso S, Ricciardi S, Brina D, Biffo S.
Oncotarget (2015) 6:37471-85

Epigenetic alterations in cancer and personalized cancer treatment.
Miozzo M, Vaira V, Sirchia SM.
Future Oncol (2015) 11:333-48

Reference proteome of highly purified human Th1 cells reveals strong effects on metabolism and protein ubiquitination upon differentiation.
Pagani M, Rockstroh M, Schuster M, Rossetti G, Moro M, Crosti M, Tomm JM.
Proteomics (2015) 15:3644-7

Long Intergenic Non-Coding RNAs: Novel Drivers of Human Lymphocyte Differentiation.
Panzeri I, Rossetti G, Abrignani S, Pagani M.
Front Immunol (2015) 6:175

Direct and high throughput (HT) interactions on the ribosomal surface by iRIA.
Pesce E, Minici C, Babetaler J, Hurt E, Degano M, Calamita P, Biffo S.
Sci Rep (2015) 5:15401

The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.
Ranzani V, Rossetti G, Panzeri I, Arrigoni A, Bonnal RJ, Curti S, Gruarin P, Provasi E, Sugliano E, Marconi M, De Francesco R, Geginat J, Bodega B, Abrignani S, Pagani M.
Nat Immunol (2015) 16:318-325

Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation.
Ricciardi S, Miluzio A, Brina D, Clarke K, Bonomo M, Aiolfi R, Guidotti LG, Falciani F, Biffo S.
J Thromb Haemost (2015) 13:2108-18

A new mouse avatar model of non-small cell lung cancer.
Russo MV, Faversani A, Gatti S, Ricca D, Del Gobbo A, Ferrero S, Palleschi A, Vaira V, Bosari S.
Front Oncol (2015) 5:52

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth.
Zanconato F, Forcato M, Battilana G, Azzolin L, Quaranta E, Bodega B, Rosato A, Bicciato S, Cordenonsi M, Piccolo S.
Nat Cell Biol (2015) 17:1218-27

Enhancement of Muscle T Regulatory Cells and Improvement of Muscular Dystrophic Process in mdx Mice by Blockade of Extracellular ATP/P2X Axis.
Gazzerro E, Baldassari S, Assereto S, Fruscione F, Pistorio A, Panicucci C, Volpi S, Perruzza L, Fiorillo C, Minetti C, Traggiai E, Grassi F, Bruno C.
Am J Pathol. (2015); 185(12):3349-60.

 

 

 

 

 

Absence of a role for interleukin-13 in inflammatory bowel disease.
Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque SS, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza GR, MacDonald TT.
Eur J Immunol (2014) 44:370-85

Repetitive elements dynamics in cell identity programming, maintenance and disease.
Bodega B, Orlando V.
Curr Opin Cell Biol (2014) 31:67-73

Third trimester NG2-positive amniotic fluid cells are effective in improving repair in spinal cord injury.
Bottai D, Scesa G, Cigognini D, Adami R, Nicora E, Abrignani S, Di Giulio AM, Gorio A.
Exp Neurol (2014) 254:121-33

The association of IL28B genotype with the histological features of chronic hepatitis C is HCV genotype dependent.
D’Ambrosio R, Aghemo A, De Francesco R, Rumi MG, Galmozzi E, De Nicola S, Cheroni C, Clark PJ, Ronchi G, Lampertico P, Colombo M.
Int J Mol Sci (2014) 15:7213-24

Serum microRNAs as Biomarkers of Human Lymphocyte Activation in Health and Disease.
de Candia P, Torri A, Pagani M, Abrignani S.
Front Immunol (2014) 5:43

Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C.
De Nicola S, Dongiovanni P, Aghemo A, Cheroni C, D’Ambrosio R, Pedrazzini M, Marabita F, Donnici L, Maggioni M, Fargion S, Colombo M, De Francesco R, Valenti L.
PLoS One (2014) 9:e106022

Interleukin 28B genotype and insulin resistance in chronic hepatitis C patients.
Degasperi E, Valenti L, Aghemo A, De Francesco R, Rumi M, Soffredini R, Donnici L, Cheroni C, Fargion S, Zanoni V, Orsi E, Colombo M.
Antivir Ther (2014) 19:747-53

iNKT-cell help to B cells: a cooperative job between innate and adaptive immune responses.
Dellabona P, Abrignani S, Casorati G.
Eur J Immunol (2014) 44:2230-7

In vitro antibiofilm activity of bioactive glass S53P4.
Drago L, Vassena C, Fenu S, De Vecchi E, Signori V, De Francesco R, Romano CL.
Future Microbiol (2014) 9:593-601

Plasticity of human CD4 T cell subsets.
Geginat J, Paroni M, Maglie S, Alfen JS, Kastirr I, Gruarin P, De Simone M, Pagani M, Abrignani S.
Front Immunol (2014) 5:630

A proteomic approach to investigate AuNPs effects in Balb/3T3 cells.
Gioria S, Chassaigne H, Carpi D, Parracino A, Meschini S, Barboro P, Rossi F.
Toxicol Lett (2014) 228:111-26

IL-21 is a central memory T cell-associated cytokine that inhibits the generation of pathogenic Th1/17 effector cells.
Kastirr I, Maglie S, Paroni M, Alfen JS, Nizzoli G, Sugliano E, Crosti MC, Moro M, Steckel B, Steinfelder S, Stolzel K, Romagnani C, Botti F, Caprioli F, Pagani M, Abrignani S, Geginat J.
J Immunol (2014) 193:3322-31

Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.
McGivern DR, Masaki T, Williford S, Ingravallo P, Feng Z, Lahser F, Asante-Appiah E, Neddermann P, De Francesco R, Howe AY, Lemon SM.
Gastroenterology (2014) 147:453-62 e7

The characterization of a novel monoclonal antibody against CD93 unveils a new antiangiogenic target.
Orlandini M, Galvagni F, Bardelli M, Rocchigiani M, Lentucci C, Anselmi F, Zippo A, Bini L, Oliviero S.
Oncotarget (2014) 5:2750-60

Diet composition transiently modulates proliferative and potency features of human cord blood-derived mesenchymal stem cells.
Ragni E, Parazzi V, Crosti M, Moro M, Giordano R, Lazzari L.
Int J Biochem Cell Biol (2014) 55:269-78

NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIalpha complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes.
Reghellin V, Donnici L, Fenu S, Berno V, Calabrese V, Pagani M, Abrignani S, Peri F, De Francesco R, Neddermann P.
Antimicrob Agents Chemother (2014) 58:7128-40

Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis.
Selmi C, Cavaciocchi F, Lleo A, Cheroni C, De Francesco R, Lombardi SA, De Santis M, Meda F, Raimondo MG, Crotti C, Folci M, Zammataro L, Mayo MJ, Bach N, Shimoda S, Gordon SC, Miozzo M, Invernizzi P, Podda M, Scavelli R, Martin MR, Seldin MF, Lasalle JM, Gershwin ME.
Front Immunol (2014) 5:128

Photodynamic antibacterial and antibiofilm activity of RLP068/Cl against Staphylococcus aureus and Pseudomonas aeruginosa forming biofilms on prosthetic material.
Vassena C, Fenu S, Giuliani F, Fantetti L, Roncucci G, Simonutti G, Romano CL, De Francesco R, Drago L.
Int J Antimicrob Agents (2014) 44:47-55

Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.
Wang H, Perry JW, Lauring AS, Neddermann P, De Francesco R, Tai AW.
Gastroenterology (2014) 146:1373-85 e1-11

Why is it so difficult to develop a hepatitis C virus preventive vaccine?
Zingaretti C, De Francesco R, Abrignani S.
Clin Microbiol Infect (2014) 20 Suppl 5:103-9

 

 

 

 

 

 

New horizons in hepatitis C antiviral therapy with direct-acting antivirals.
Aghemo A, De Francesco R.
Hepatology (2013) 58:428-38

Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients.
Aghemo A, Degasperi E, Rumi MG, Galmozzi E, Valenti L, De Francesco R, De Nicola S, Cheroni C, Grassi E, Colombo M.
Biomed Res Int (2013) 2013:580796

 

Reduction of CD68+ macrophages and decreased IL-17 expression in intestinal mucosa of patients with inflammatory bowel disease strongly correlate with endoscopic response and mucosal healing following infliximab therapy.
Caprioli F, Bose F, Rossi RL, Petti L, Vigano C, Ciafardini C, Raeli L, Basilisco G, Ferrero S, Pagani M, Conte D, Altomare G, Monteleone G, Abrignani S, Reali E.
Inflamm Bowel Dis (2013) 19:729-39

 

Intracellular modulation, extracellular disposal and serum increase of MiR-150 mark lymphocyte activation.
de Candia P, Torri A, Gorletta T, Fedeli M, Bulgheroni E, Cheroni C, Marabita F, Crosti M, Moro M, Pariani E, Romano L, Esposito S, Mosca F, Rossetti G, Rossi RL, Geginat J, Casorati G, Dellabona P, Pagani M, Abrignani S.
PLoS One (2013) 8:e75348

 

Hepatitis C virus-specific directly acting antiviral drugs.
Delang L, Neyts J, Vliegen I, Abrignani S, Neddermann P, De Francesco R.
Curr Top Microbiol Immunol (2013) 369:289-320

 

The CD4-centered universe of human T cell subsets.
Geginat J, Paroni M, Facciotti F, Gruarin P, Kastirr I, Caprioli F, Pagani M, Abrignani S.
Semin Immunol (2013) 25:252-62

 

IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B.
Lampertico P, Vigano M, Cheroni C, Facchetti F, Invernizzi F, Valveri V, Soffredini R, Abrignani S, De Francesco R, Colombo M.
Hepatology (2013) 57:890-6

 

A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans.
Law JL, Chen C, Wong J, Hockman D, Santer DM, Frey SE, Belshe RB, Wakita T, Bukh J, Jones CT, Rice CM, Abrignani S, Tyrrell DL, Houghton M.
PLoS One (2013) 8:e59776

 

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.
Nizzoli G, Krietsch J, Weick A, Steinfelder S, Facciotti F, Gruarin P, Bianco A, Steckel B, Moro M, Crosti M, Romagnani C, Stolzel K, Torretta S, Pignataro L, Scheibenbogen C, Neddermann P, De Francesco R, Abrignani S, Geginat J.
Blood (2013) 122:932-42

 

Role of microRNAs and long-non-coding RNAs in CD4(+) T-cell differentiation.
Pagani M, Rossetti G, Panzeri I, de Candia P, Bonnal RJ, Rossi RL, Geginat J, Abrignani S.
Immunol Rev (2013) 253:82-96

 

 

 

 

 

 

 

 

Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case.
Bensi G, Mora M, Tuscano G, Biagini M, Chiarot E, Bombaci M, Capo S, Falugi F, Manetti AG, Donato P, Swennen E, Gallotta M, Garibaldi M, Pinto V, Chiappini N, Musser JM, Janulczyk R, Mariani M, Scarselli M, Telford JL, Grifantini R, Norais N, Margarit I, Grandi G.
Mol Cell Proteomics (2012) 11:M111 015693

 

Metabolism of phosphatidylinositol 4-kinase IIIalpha-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity.
Bianco A, Reghellin V, Donnici L, Fenu S, Alvarez R, Baruffa C, Peri F, Pagani M, Abrignani S, Neddermann P, De Francesco R.
PLoS Pathog (2012) 8:e1002576

 

Biogem: an effective tool-based approach for scaling up open source software development in bioinformatics.
Bonnal RJ, Aerts J, Githinji G, Goto N, MacLean D, Miller CA, Mishima H, Pagani M, Ramirez-Gonzalez R, Smant G, Strozzi F, Syme R, Vos R, Wennblom TJ, Woodcroft BJ, Katayama T, Prins P.
Bioinformatics (2012) 28:1035-7

 

Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4.
De Nicola S, Aghemo A, Rumi MG, Galmozzi E, Valenti L, Soffredini R, De Francesco R, Prati GM, D’Ambrosio R, Cheroni C, Donato MF, Colombo M.
Hepatology (2012) 55:336-42

 

Surface interactome in Streptococcus pyogenes.
Galeotti CL, Bove E, Pezzicoli A, Nogarotto R, Norais N, Pileri S, Lelli B, Falugi F, Balloni S, Tedde V, Chiarot E, Bombaci M, Soriani M, Bracci L, Grandi G, Grifantini R.
Mol Cell Proteomics (2012) 11:M111 015206

 

Identification of new hematopoietic cell subsets with a polyclonal antibody library specific for neglected proteins.
Moro M, Crosti M, Creo P, Gallina P, Curti S, Sugliano E, Scavelli R, Cattaneo D, Canidio E, Marconi M, Rebulla P, Sarmientos P, Viale G, Pagani M, Abrignani S.
PLoS One (2012) 7:e34395

 

Circulating hepatitis B surface antigen particles carry hepatocellular microRNAs.
Novellino L, Rossi RL, Bonino F, Cavallone D, Abrignani S, Pagani M, Brunetto MR.
PLoS One (2012) 7:e31952

 

Development of an influenza virus protein array using Sortagging technology.
Sinisi A, Popp MW, Antos JM, Pansegrau W, Savino S, Nissum M, Rappuoli R, Ploegh HL, Buti L.
Bioconjug Chem (2012) 23:1119-26

 

Follicular helper NKT cells induce limited B cell responses and germinal center formation in the absence of CD4(+) T cell help.
Tonti E, Fedeli M, Napolitano A, Iannacone M, von Andrian UH, Guidotti LG, Abrignani S, Casorati G, Dellabona P.
J Immunol (2012) 188:3217-22

 

Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis.
Zingaretti C, Arigo M, Cardaci A, Moro M, Crosti M, Sinisi A, Sugliano E, Cheroni C, Marabita F, Nogarotto R, Bonnal RJ, Marcatili P, Marconi M, Zignego A, Muratori P, Invernizzi P, Colombatto P, Brunetto M, Bonino F, De Francesco R, Geginat J, Pagani M, Muratori L, Abrignani S, Bombaci M.
Mol Cell Proteomics (2012) 11:1885-97

 

 

 

 

 

 

 

 

Dual role of anti-TNF therapy: enhancement of TCR-mediated T cell activation in peripheral blood and inhibition of inflammation in target tissues.
Bose F, Raeli L, Garutti C, Frigerio E, Cozzi A, Crimi M, Caprioli F, Scavelli R, Altomare G, Geginat J, Abrignani S, Reali E.
Clin Immunol (2011) 139:164-76

 

Substantial histone reduction modulates genomewide nucleosomal occupancy and global transcriptional output.
Celona B, Weiner A, Di Felice F, Mancuso FM, Cesarini E, Rossi RL, Gregory L, Baban D, Rossetti G, Grianti P, Pagani M, Bonaldi T, Ragoussis J, Friedman N, Camilloni G, Bianchi ME, Agresti A.
PLoS Biol (2011) 9:e1001086

 

Nutritional limitation sensitizes mammalian cells to GSK-3beta inhibitors and leads to growth impairment.
de Candia P, Minopoli G, Verga V, Gargiulo A, Vanoni M, Alberghina L.
Am J Pathol (2011) 178:1814-23

 

A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dolle P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A.
PLoS Biol (2011) 9:e1000582

 

A novel polyclonal antibody library for expression profiling of poorly characterized, membrane and secreted human proteins.
Grifantini R, Pagani M, Pierleoni A, Grandi A, Parri M, Campagnoli S, Pileri P, Cattaneo D, Canidio E, Pontillo A, De Camilli E, Bresciani A, Marinoni F, Pedrazzoli E, Nogarotto R, Abrignani S, Viale G, Sarmientos P, Grandi G.
J Proteomics (2011) 75:532-47

 

Genetic variation in the interleukin-28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection.
Marabita F, Aghemo A, De Nicola S, Rumi MG, Cheroni C, Scavelli R, Crimi M, Soffredini R, Abrignani S, De Francesco R, Colombo M.
Hepatology (2011) 54:1127-34

 

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase.
Narjes F, Crescenzi B, Ferrara M, Habermann J, Colarusso S, Ferreira Mdel R, Stansfield I, Mackay AC, Conte I, Ercolani C, Zaramella S, Palumbi MC, Meuleman P, Leroux-Roels G, Giuliano C, Fiore F, Di Marco S, Baiocco P, Koch U, Migliaccio G, Altamura S, Laufer R, De Francesco R, Rowley M.
J Med Chem (2011) 54:289-301

 

Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b.
Rossi RL, Rossetti G, Wenandy L, Curti S, Ripamonti A, Bonnal RJ, Birolo RS, Moro M, Crosti MC, Gruarin P, Maglie S, Marabita F, Mascheroni D, Parente V, Comelli M, Trabucchi E, De Francesco R, Geginat J, Abrignani S, Pagani M.
Nat Immunol (2011) 12:796-803

 

Immunization of human volunteers with hepatitis C virus envelope glycoproteins elicits antibodies that cross-neutralize heterologous virus strains.
Stamataki Z, Coates S, Abrignani S, Houghton M, McKeating JA.
J Infect Dis (2011) 204:811-3

 

Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells.
Steinfelder S, Floess S, Engelbert D, Haeringer B, Baron U, Rivino L, Steckel B, Gruetzkau A, Olek S, Geginat J, Huehn J, Hamann A.
Blood (2011) 117:2839-46

 

 

 

 

 

 

 

Reliable resequencing of the human dystrophin locus by universal long polymerase chain reaction and massive pyrosequencing.
Bonnal RJ, Severgnini M, Castaldi A, Bordoni R, Iacono M, Trimarco A, Torella A, Piluso G, Aurino S, Condorelli G, De Bellis G, Nigro V.
Anal Biochem (2010) 406:176-84

 

Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults.
Frey SE, Houghton M, Coates S, Abrignani S, Chien D, Rosa D, Pileri P, Ray R, Di Bisceglie AM, Rinella P, Hill H, Wolff MC, Schultze V, Han JH, Scharschmidt B, Belshe RB.
Vaccine (2010) 28:6367-73

 

BioRuby: bioinformatics software for the Ruby programming language.
Goto N, Prins P, Nakao M, Bonnal R, Aerts J, Katayama T.
Bioinformatics (2010) 26:2617-9

 

RSSsite: a reference database and prediction tool for the identification of cryptic Recombination Signal Sequences in human and murine genomes.
Merelli I, Guffanti A, Fabbri M, Cocito A, Furia L, Grazini U, Bonnal RJ, Milanesi L, McBlane F.
Nucleic Acids Res (2010) 38:W262-7

 

Characterization of nucleotide misincorporation patterns in the iceman’s mitochondrial DNA.
Olivieri C, Ermini L, Rizzi E, Corti G, Bonnal R, Luciani S, Marota I, De Bellis G, Rollo F.
PLoS One (2010) 5:e8629

 

Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines.
Powdrill MH, Deval J, Narjes F, De Francesco R, Gotte M.
Antimicrob Agents Chemother (2010) 54:977-83

 

Characterization of antibodies induced by vaccination with hepatitis C virus envelope glycoproteins.
Ray R, Meyer K, Banerjee A, Basu A, Coates S, Abrignani S, Houghton M, Frey SE, Belshe RB.
J Infect Dis (2010) 202:862-6

 

CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function.
Rivino L, Gruarin P, Haringer B, Steinfelder S, Lozza L, Steckel B, Weick A, Sugliano E, Jarrossay D, Kuhl AA, Loddenkemper C, Abrignani S, Sallusto F, Lanzavecchia A, Geginat J.
J Exp Med (2010) 207:565-77

 

Biology of interleukin-10.
Sabat R, Grutz G, Warszawska K, Kirsch S, Witte E, Wolk K, Geginat J.
Cytokine Growth Factor Rev (2010) 21:331-44

 

Streptococcus pyogenes SpyCEP: a chemokine-inactivating protease with unique structural and biochemical features.
Zingaretti C, Falugi F, Nardi-Dei V, Pietrocola G, Mariani M, Liberatori S, Gallotta M, Tontini M, Tani C, Speziale P, Grandi G, Margarit I.
FASEB J (2010) 24:2839-48

 

 

 

 

 

B cell helper assays.
Abrignani S, Tonti E, Casorati G, Dellabona P.
Methods Mol Biol (2009) 514:15-26

The mitochondrial genome, a growing interest inside an organelle.
Crimi M, Rigolio R.
Int J Nanomedicine (2008) 3:51-7