Dissecting human immune responses to pathogens and vaccines

My laboratory investigates the mechanisms of antibody-mediated resistance to infectious diseases. Using high-throughput cellular screens we isolated potent and broadly neutralizing antibodies that can be used for prophylaxis and treatment of infectious diseases and as tools for vaccine design. We also addressed fundamental aspects of the antibody response, such as the role of somatic mutations in affinity maturation and the relationship between infection and autoimmunity. Recently, while studying the antibody response to the malaria parasite, we discovered a new type of antibodies generated by the insertion of genomic DNA encoding pathogen receptors into antibody genes. In INGM laboratory, we will combine cellular and molecular approaches to gain fundamental insights into the organization and dynamics of human memory B cell repertoires and will explore new strategies to engineer antibodies and B cells to improve and exploit their therapeutic efficacy. This work will be mainly supported by the ERC grant ENGRAB “Antibody engineering by natural selection and by design”.


  • The organization and dynamics of human memory B cell repertoires
  • Antibody diversification through templated insertions: receptor-based antibodies and beyond
  • Dissecting the antibody response to SARS-CoV-2
  • Antibody-guided vaccine design
  • Lymphocyte engineering using gene knock-out and knock-in approaches

Publications (selected, last 10 years)