Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
Bowen J E, Addetia A, Dang Ha V, Stewart C, Brown J T, Sharkey W K, Sprouse K R, Walls A C, Mazzitelli I C, Logue J K, Franko N M, Czudnochowski N, Powell A E, Dellota E Jr, Ahmed K, Shariq Ansari A, Cameroni E, Gori A, Bandera A, Posavad C M, Dan J M, Zhang Z, Weiskopf D, Sette A, Shane Crotty S, Talat Iqba N, Corti D, Geffner J, Snell G, Grifantini R, Chu E Y, Veesler D
Science, 19 Jul 2022, First Release, DOI: 10.1126/science.abq0203

Deep Phenotyping of T-Cells Derived From the Aneurysm Wall in a Pediatric Case of Subarachnoid Hemorrhage.
Moschetti G, Vasco C, Clemente F, Galeota E, Carbonara M, Pluderi M, Locatelli M, Stocchetti N, Abrignani S, Zanier ER, Ortolano F, Zoerle T, Geginat J.
Front Immunol. 2022 May 31;13:866558.

Immunosuppressant Treatment in Rheumatic Musculoskeletal Diseases Does Not Inhibit Elicitation of Humoral Response to SARS-CoV-2 Infection and Preserves Effector Immune Cell Populations
Favalli A, Favalli E G, Gobbini A, Zagato E, Bombaci M, Maioli G, Pesce E, Donnici L, Gruarin P, Biggioggero M, Curti S, Manganaro L, Marchisio E, Bevilacqua V, Martinovic M, Fabbris T, 1 , Sarnicola ML, Crosti M, Marongiu L, Granucci F, Notarbartolo S, Bandera A, Gori A, De Francesco R, Abrignani S, Caporali R, Grifantini R.
Front Immunol. 2022 Jun 10;13:873195. doi: 10.3389/fimmu.2022.873195. eCollection 2022.

Heterogeneity of Latency Establishment in the Different Human CD4+ T Cell Subsets Stimulated with IL-15.
Butta GM, Bozzi G, Gallo G, Copaloni G, Cordiglieri C, Crosti M, Mancino M, Prati D, Simon V, Gori A, Bandera A, De Francesco R, Manganaro L.
J Virol. 2022 May 2:e0037922.

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody.
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB.
Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2120976119.

Synthetic Carbohydrate Binding Agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2
Francesconi O, Donnici L, Fragai M, Pesce E, Bombaci M, Fasciani A, Manganaro L, Conti M, Grifantini R, De Francesco R, Nativi C, Roelens S.
iScience. 2022 May 20;25(5):104239. Epub 2022 Apr 11.PMID: 35434540.

The impact of anti-rheumatic drugs on the seroprevalence of anti-SARS-CoV-2 antibodies in a cohort of patients with inflammatory arthritis: the MAINSTREAM study
Favalli EG, Gobbini A, Bombaci M, Maioli G, Biggioggero M, Pesce E, Favalli A, Martinovic M, Fabbris T, Marchisio E, Bandiera A, Gori A, Abrignani S, Grifantini RG and Caporali R.
Frontiers in medicine, 2022 Mar 11

Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia.
Poli V, Di Gioia M, Sola-Visner M, Granucci F, Frelinger AL 3rd, Michelson AD, Zanoni I.
Immunity. 2022 Feb 8;55(2):224-236.e5.

Pulmonary Langerhans cell histiocystosis (PLCH) and lymphangioleiomyomatosis (LAM) have circulating cells with loss of heterozygosity of the TSC2 gene.
Elia D, Torre O, Vasco C, Geginat J, Abrignani S, Bulgheroni E, Carelli E, Cassandro R, Pacheco-Rodriguez G, Steagall WK, Moss J, Harari S.
Chest. 2022 Feb 26:S0012-3692(22)00398-1.

Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response
Pesce E, Manfrini N, Cordiglieri C, Santi S, Bandera A, Gobbini A, Gruarin P, Favalli A, Bombaci M, Cuomo A, Collino F, Cricrì G, Ungaro R, Lombardi A, Mangioni D, Muscatello A, Aliberti S, Blasi F, Gori A, Abrignani S, De Francesco R, Biffo S and Grifantini R.
Front. Immunol., 2022 Jan 17, doi.org/10.3389/fimmu.2021.785941

LINE1 elements are spliced in non-canonical transcript variants to control gene expression in human T cell quiescence and exhaustion
Marasca F, Sinha S, Vadalà R, Polimeni B, Ranzani V, Paraboschi E, Burattin FV, Ghilotti M, Crosti MC, Negri ML, Campagnoli S, Notarbartolo S, Bianchi AS, Siena S, Prati D, Montini G, Viale G, Torre O, Harari S, Grifantini R, Soldà G, Biffo S, Abrignani S, Bodega B.
Nat Genet. 2022 Jan 17, doi: 10.1038/s41588-021-00989-7.

Anti-spike antibodies and neutralising antibody activity in people living with HIV vaccinated with COVID-19 mRNA-1273 vaccine: a prospective single-centre cohort study.
Lombardi A, Butta GM, Donnici L, Bozzi G, Oggioni M, Bono P, Matera M, Consonni D, Ludovisi S, Muscatello A, Ceriotti F, Conti M, Scaglioni S, Gallo G, Scarpa E, Letko M, Abrignani S, Grifantini R, De Francesco R, Gori A, Manganaro L, Bandera A.
Lancet Reg Health Eur. 2022 Feb;13:100287

Production of anti-PF4 antibodies in antiphospholipid antibody-positive patients is not affected by COVID-19 vaccination
Lonati PA, Bodio C, Scavone M, Martini G, Pesce E, Bandera A, Lombardi A, Gerosa M, Franceschini F, Tincani A, Podda G, Abrignani S, Grifantini R, Cattaneo M, Borghi MO, Meroni PL.
RMD Open. 2022 Feb;8(1):e001902. doi: 10.1136/rmdopen-2021-001902.

Untargeted Mass Spectrometry Approach to Study SARS-CoV-2 Proteins in Human Plasma and Saliva Proteome
Pagani L, Chinello C, Mahajneh A, Clerici F, Criscuolo L, Favalli A, Gruarin P, Grifantini RM, Bandera A, Lombardi A, Ungaro R, Muscatello A, Blasi F, Gori A, Magni F.
BioChem. 2022, Feb 8; 2(1), 64-82

Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion
Fumagalli V, Ravà M, Marotta D, Di Lucia P, Laura C, Sala E, Grillo M, Bono E, Giustini L, Perucchini C, Mainetti M, Sessa A, Garcia-Manteiga JM, Donnici L, Manganaro L, Delbue S, Broccoli V, De Francesco R, D’Adamo P, Kuka M, Guidotti LG, Iannacone M.
Sci Immunol. 2022 Jan 28;7(67):eabl9929. doi: 10.1126/sciimmunol.abl9929. Epub 2022 Jan 28.

Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern
Wratil PR, Stern M, Priller A, Willmann A, Almanzar G, Vogel E, Feuerherd M, Cheng CC, Yazici S, Christa C, Jeske S, Lupoli G, Vogt T, Albanese M, Mejías-Pérez E, Bauernfried S, Graf N, Mijocevic H, Vu M, Tinnefeld K, Wettengel J, Hoffmann D, Muenchhoff M, Daechert C, Mairhofer H, Krebs S, Fingerle V, Graf A, Steininger P, Blum H, Hornung V, Liebl B, Überla K, Prelog M, Knolle P, Keppler OT, Protzer U.
Nat Med. 2022 Jan 28. doi: 10.1038/s41591-022-01715-4. Online ahead of print.

The dominant p.Thr274Pro mutation in the von Willebrand factor propeptide causes the von Willebrand disease type 1 phenotype in two unrelated patients.
Pagliari MT, Baronciani L, Cordiglieri C, Colpani P, Cozzi G, Siboni SM, Peyvandi F.
Haemophilia. 2022 Jan 22. doi: 10.1111/hae.14494

DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic
Villa A, Brunialti E, Dellavedova J, Meda C, Rebecchi M, Conti M, Donnici L, Francesco R, Reggiani A, Lionetti V, Ciana P.
Pharmacol Res. 2022 Jan;175:105982.

COVID-eVax, an electroporated plasmid DNA vaccine candidate encoding the SARS-CoV-2 Receptor Binding Domain, elicits protective immune responses in animal models of COVID-19
Conforti A, Marra E, Palombo F, Roscilli G, Ravà M, Fumagalli V, Muzi A, Maffei M, Luberto L, Lione L, Salvatori E, Compagnone M, Pinto E, Pavoni E, Bucci F, Vitagliano G, Stoppoloni D, Pacello ML, Cappelletti M, Ferrara FF, D’Acunto E, Chiarini V, Arriga R, Nyska A, Di Lucia P, Marotta D, Bono E, Giustini L, Sala E, Perucchini C, Paterson J, Ryan KA, Challis AR, Matusali G, Colavita F, Caselli G, Criscuolo E, Clementi N, Mancini N, Groß R, Seidel A, Wettstein L, Münch J, Donnici L, Conti M, De Francesco R, Kuka M, Ciliberto G, Castilletti C, Capobianchi MR, Ippolito G, Guidotti LG, Rovati L, Iannacone M, Aurisicchio L.
Mol Ther. 2022 Jan 5;30(1):311-326

Elucidating the 3D Structure of a Surface Membrane Antigen from Trypanosoma cruzi as a Serodiagnostic Biomarker of Chagas Disease
Di Pisa F, De Benedetti S, Fassi EMA, Bombaci M, Grifantini R, Musicò A, Frigerio R, Pontillo A, Rigo C, Abelli S, Grande R, Zanchetta N, Mileto D, Mancon A, Rizzo A, Gori A, Cretich M, Colombo G, Bolognesi M, Gourlay LJ.
Vaccines (Basel). 2022 Jan 3;10(1):71

Assessment of Sacsin Turnover in Patients With ARSACS: Implications for Molecular Diagnosis and Pathogenesis.
Longo F, De Ritis D, Miluzio A, Fraticelli D, Baets J, Scarlato M, Santorelli FM, Biffo S, Maltecca F.
Neurology. 2021 Oct 14:10.1212/WNL.0000000000012962.

How dendritic cells sense and respond to viral infections.
Marongiu L, Valache M, Facchini FA, Granucci F.
Clin Sci (Lond). 2021 Oct 14;135(19):2217-2242.

ERα-independent NRF2-mediated immunoregulatory activity of tamoxifen.
Pepe G, Sfogliarini C, Rizzello L, Battaglia G, Pinna C, Rovati G, Ciana P, Brunialti E, Mornata F, Maggi A, Locati M, Vegeto E.
Biomed Pharmacother. 2021 Oct 12;144:112274.

COVID-eVax, an electroporated plasmid DNA vaccine candidate encoding the SARS-CoV-2 Receptor Binding Domain, elicits protective immune responses in animal models of COVID-19.
Conforti A, Marra E, Palombo F, Roscilli G, Ravà M, Fumagalli V, Muzi A, Maffei M, Luberto L, Lione L, Salvatori E, Compagnone M, Pinto E, Pavoni E, Bucci F, Vitagliano G, Stoppoloni D, Pacello ML, Cappelletti M, Ferrara FF, D’Acunto E, Chiarini V, Arriga R, Nyska A, Di Lucia P, Marotta D, Bono E, Giustini L, Sala E, Perucchini C, Paterson J, Ryan KA, Challis AR, Matusali G, Colavita F, Caselli G, Criscuolo E, Clementi N, Mancini N, Groß R, Seidel A, Wettstein L, Münch J, Donnici L, Conti M, De Francesco R, Kuka M, Ciliberto G, Castilletti C, Capobianchi MR, Ippolito G, Guidotti LG, Rovati L, Iannacone M, Aurisicchio L.
Mol Ther. 2021 Sep 18:S1525-0016(21)00466-4.

Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies
Celikkin N, Presutti D, Maiullari F, Fornetti E, Agarwal T, Paradiso A, Volpi M, Swieszkowski W, Bearzi C, Barbetta A, Zhang YS, Gargioli C, Rizzi R and Costantini M.
Front. Bioeng. Biotechnol. 2021 Sept. 16, 9:732130. doi: 10.3389/fbioe.2021.732130

Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R
De Simone M, Chirichella M, Emming S, Mazzara S, Ranzani V, Gruarin P, Moschetti G, Pulvirenti N, Maglie S, Vasco C, Crosti MC, Rossetti G, Pagani M, Abrignani S, Monticelli S, Geginat J.
Eur J Immunol. 2021 Sep 15. doi: 10.1002/eji.202149315.

Novel interferon‑sensitive genes unveiled by correlation‑driven gene selection and systems biology
Cheroni C, Manganaro L, Donnici L, Bevilacqua V, Bonnal JP, Rossi RL, De Francesco R.
Sci Rep. 2021 Sep 10;11(1):18043. doi: 10.1038/s41598-021-97258-8

Endosomal trafficking and DNA damage checkpoint kinases dictate survival to replication stress by regulating amino acid uptake and protein synthesis.
Ajazi A, Bruhn C, Shubassi G, Lucca C, Ferrari E, Cattaneo A, Bachi A, Manfrini N, Biffo S, Martini E, Minucci S, Vernieri C, Foiani M.
Dev Cell. 2021 Sep 8:S1534-5807(21)00678-X.

Maturation signatures of conventional dendritic cell subtypes in COVID-19 suggest direct viral sensing.
Marongiu L, Protti G, Facchini FA, Valache M, Mingozzi F, Ranzani V, Putignano AR, Salviati L, Bevilacqua V, Curti S, Crosti M, Sarnicola ML, D’Angiò M, Bettini LR, Biondi A, Nespoli L, Tamini N, Clementi N, Mancini N, Abrignani S, Spreafico R, Granucci F.
Eur J Immunol. 2021 Aug 1:10.1002/eji.202149298.

Targeting HDAC8 to ameliorate skeletal muscle differentiation in Duchenne muscular dystrophy.
Spreafico M, Cafora M, Bragato C, Capitanio D, Marasca F, Bodega B, De Palma C, Mora M, Gelfi C, Marozzi A, Pistocchi A.
Pharmacol Res. 2021 Aug;170:105750.

Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients.
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Sci Immunol. 2021 Aug 10;6(62):eabg5021.

Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma.
Scagliola A, Miluzio A, Ventura G, Oliveto S, Cordiglieri C, Manfrini N, Cirino D, Ricciardi S, Valenti L, Baselli G, D’Ambrosio R, Maggioni M, Brina D, Bresciani A, Biffo S.
Nat Commun. 2021 Aug 12;12(1):4878.

Phosphorylation of H3-Thr3 by Haspin Is Required for Primary Cilia Regulation.
Quadri R, Sertic S, Ghilardi A, Rondelli D, Gallo GR, Del Giacco L, Muzi-Falconi M.
Int J Mol Sci. 2021 Jul 20;22(14):7753.

Synergistic Effect Induced by Gold Nanoparticles with Polyphenols Shell during Thermal Therapy: Macrophage Inflammatory Response and Cancer Cell Death Assessment.
De Matteis V, Cascione M, Rizzello L, Manno DE, Di Guglielmo C, Rinaldi R.
Cancers (Basel). 2021 Jul 19;13(14):3610.

Focus on the road to modelling cardiomyopathy in muscular dystrophy
Canonico F, Chirivi M, Maiullari F, Milan M, Rizzi R, Arcudi A, Galli M, Pane M, Gowran A, Pompilio G, Mercuri E, Crea F, Bearzi C, D’Amario D.
Cardiovascular Research, 2021 Jul 12;cvab232. doi: 10.1093/cvr/cvab232.

Pre-Drawn Syringes of Comirnaty for an Efficient COVID-19 Mass Vaccination: Demonstration of Stability.
Selmin F, Musazzi UM, Franzè S, Scarpa E, Rizzello L, Procacci P, Minghetti P.
Pharmaceutics. 2021 Jul 7;13(7):1029.

ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington’s disease
Cozzolino F, Vezzoli E, Cheroni C, Besusso D, Conforti P, Valenza M, Iacobucci I, Monaco V, Birolini, Bombaci M, Falqui A, Saftig P, Rossi R, Monti M, Cattaneo E, Zuccato C.
Hum Mol Genet. 2021 Jun 17;30(13):1175-1187. doi: 10.1093/hmg/ddab047

Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression.
Bonnal RJP, Rossetti G, Lugli E, De Simone M, Gruarin P, Brummelman J, Drufuca L, Passaro M, Bason R, Gervasoni F, Della Chiara G, D’Oria C, Martinovic M, Curti S, Ranzani V, Cordiglieri C, Alvisi G, Mazza EMC, Oliveto S, Silvestri Y, Carelli E, Mazzara S, Bosotti R, Sarnicola ML, Godano C, Bevilacqua V, Lorenzo M, Siena S, Bonoldi E, Sartore-Bianchi A, Amatu A, Veronesi G, Novellis P, Alloisio M, Giani A, Zucchini N, Opocher E, Ceretti AP, Mariani N, Biffo S, Prati D, Bardelli A, Geginat J, Lanzavecchia A, Abrignani S, Pagani M.
Nat Immunol. 2021 May 20. doi: 10.1038/s41590-021-00930-4.

A High-Throughput Chromatin Immunoprecipitation Sequencing Approach to Study the Role of MYC on the Epigenetic Landscape
Fagnocchi L, Zippo A.
Methods Mol Biol. 2021;2318:187-208.doi: 10.1007/978-1-0716-1476-1_9

Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties.
Lucà R, Assenza MR, Maiullari F, Pieroni L, Maiullari S, Federici G, Marini F, Rizzi R, Urbani A, Soddu S, Moretti F.
Cell Death Dis. 2021 May 29;12(6):558. doi: 10.1038/s41419-021-03828-z.

The coding and long noncoding single-cell atlas of the developing human fetal striatum.
Bocchi VD, Conforti P, Vezzoli E, Besusso D, Cappadona C, Lischetti T, Galimberti M, Ranzani V, Bonnal RJP, De Simone M, Rossetti G, He X, Kamimoto K, Espuny-Camacho I, Faedo A, Gervasoni F, Vuono R, Morris SA, Chen J, Felsenfeld D, Pavesi G, Barker RA, Pagani M, Cattaneo E.
Science. 2021 May 7;372(6542):eabf5759. doi: 10.1126/science.abf5759. PMID: 33958447.

Engineering Polymeric Nanosystems against Oral Diseases.
Mercadante V, Scarpa E, De Matteis V, Rizzello L, Poma A.
Molecules. 2021 Apr 13;26(8):2229.

Structure, Immunoreactivity, and In Silico Epitope Determination of SmSPI S. mansoni Serpin for Immunodiagnostic Application.
De Benedetti S, Di Pisa F, Fassi EMA, Cretich M, Musicò A, Frigerio R, Mussida A, Bombaci M, Grifantini R, Colombo G, Bolognesi M, Grande R, Zanchetta N, Gismondo MR, Mileto D, Mancon A, Gourlay LJ.
Vaccines (Basel). 2021 Apr 1;9(4):322.

Tumor Extracellular Matrix Stiffness Promptly Modulates the Phenotype and Gene Expression of Infiltrating T Lymphocytes
Chirivì M, Maiullari F, Milan M, Presutti D, Cordiglieri C, Crosti M, Sarnicola ML, Soluri A, Volpi M, Święszkowski W, Prati D, Rizzi M, Costantini M, Seliktar D, Parisi C, Bearzi C, Rizzi R.
Int. J. Mol. Sci.2021, 22, 5862.

Geographic differences in the incidence of Huntington’s disease in Sardinia, Italy.
Muroni A, Murru MR, Ulgheri L, Sechi M, Ercoli T, Marrosu F, Scaglione CL, Bentivoglio AR, Petracca M, Soliveri P, Cocco E, Cuccu S, Deriu M, Zuccato C, Defazio G.
Neurol Sci. 2021 Apr 1. doi: 10.1007/s10072-021-05217-y.

Role of Cdkn2a in the Emery–Dreifuss Muscular Dystrophy Cardiac Phenotype
Pegoli G, Milan M, Manti PG, Bianchi A, Lucini F, Santarelli P, Bearzi C, Rizzi R, Lanzuolo C.
Biomolecules. 2021 Apr 6;11(4):538. doi: 10.3390/biom11040538. PMID: 33917623

Huntingtin-mediated axonal transport requires arginine methylation by PRMT6.
Migazzi A, Scaramuzzino C, Anderson EN, Tripathy D, Hernández IH, Grant RA, Roccuzzo M, Tosatto L, Virlogeux A, Zuccato C, Caricasole A, Ratovitski T, Ross CA, Pandey UB, Lucas JJ, Saudou F, Pennuto M, Basso M.
Cell Rep. 2021 Apr 13;35(2):108980. doi: 10.1016/j.celrep.2021.108980.

Development of a Specific Monoclonal Antibody to Detect Male Cells Expressing the RPS4Y1 Protein
Spena S, Cordiglieri C, Garagiola I, Peyvandi F.
Int J Mol Sci. 2021 Feb 18;22(4):2001. doi: 10.3390/ijms22042001.

SREBP2 delivery to striatal astrocytes normalizes transcription of cholesterol biosynthesis genes and ameliorates pathological features in Huntington’s disease
Birolini G, Verlengia G Talpo F, Maniezzi C, Zentilin L, Giacca M, Conforti P, Cordiglieri C, Caccia C, Leoni V.
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Formaldehyde-mediated snapshot of nuclear architecture
Lucini F, Bianchi A, Lanzuolo C.
Methods Mol Biol. 2021, 2157:173-195

Chemotherapy triggers cachexia by deregulating synergetic function of histone-modifying enzymes
Amrute-Nayak M., Pegoli G., Holler T., Lopez-Davila A.J., Lanzuolo C. and Nayak A.
J Cachexia Sarcopenia Muscle 2021 Feb 12

Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells.
Marongiu L, Mingozzi F, Cigni C, Marzi R, Di Gioia M, Garrè M, Parazzoli D, Sironi L, Collini M, Sakaguchi R, Morii T, Crosti M, Moro M, Schurmans S, Catelani T, Rotem R, Colombo M, Shears S, Prosperi D, Zanoni I, Granucci F. Sci Signal. 2021 Mar 30;14(676):eaaz2120. doi: 10.1126/scisignal.aaz2120. PMID: 33785611

hiPSCs for predictive modelling of neurodegenerative diseases: dreaming the possible
Rivetti di Val Cervo P, Besusso D, Conforti P & Cattaneo E.
Nature Reviews Neurology. 2021 Mar 3:1–12. doi: 10.1038/s41582-021-00465-0. Epub ahead of print. PMID: 33658662; PMCID: PMC7928200.

Early maternal care restores LINE-1 methylation and enhances neurodevelopment in preterm infants
Fontana C, Marasca F, Provitera L, Mancinelli S, Pesenti N, Sinha S, Passera S, Abrignani S, Mosca F, Lodato S, Bodega B, Fumagalli M.
BMC Med. 2021 Feb 5;19(1):42.

Modeling autism-associated SHANK3 deficiency using human cortico-striatal organoids generated from single neural rosettes
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bioRxiv preprint, version posted January 25, 2021, doi:https://doi.org/ 10.1101/2021.01.25.428022

Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington’s disease
Birolini G, Valenza M, Ottonelli I, Passoni A, Favagrossa M, Duskey JT, Bombaci M, Vandelli MA, Colombo L, Bagnati R, Caccia C, Leoni V, Taroni F, Forni F, Ruozi B, Salmona M, Tosi G, Cattaneo E.
J Control Release. 2021 Jan 5;330:587-598.

In vivo organized neovascularization induced by 3D bioprinted endothelial-derived extracellular vesicles
Maiullari F, Chirivì M, Costantini M, Ferretti AM, Recchia S, Maiullari S, Milan M, Presutti D, Pace V, Raspa M, Scavizzi F, Massetti M, Petrella L, Fanelli M, Rizzi M, Fortunato O, Moretti F, Caradonna E, Bearzi C, Rizzi R.
Biofabrication. 2021 Jan 12. doi: 10.1088/1758-5090/abdacf.

SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome
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Nat Commun. 2020 Dec 8;11(1):6274.

Alternative Splicing Generates a MONOPTEROS Isoform Required for Ovule Development
Cucinotta M,Cavalleri A, Guazzotti A, Astori C, Manrique S, Bombarely A, Oliveto S, Biffo S, Weijers D, Kater M.M., Colombo L.
Current Biology, Dec.3, 2020, doi.org/10.1016/j.cub.2020.11.026

Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington’s disease mice
Birolini G, Valenza M, Di Paolo E, Vezzoli E, Talpo F, Maniezzi C, Caccia C, Leoni V, Taroni F, Bocchi VD, Conforti P, Sogne E, Petricca L, Cariulo C, Verani M, Caricasole A, Falqui A, Biella G, Cattaneo E.
EMBO Molecular Medicine, 2020 Epub ahead of print. 12(10):e12519

A CRISPR-strategy for the generation of a detectable fluorescent hESC reporter line (WAe009-A-37) for the subpallial determinant GSX2
Besusso D, Cossu A, Mohamed A, Cernigoj M, Codega P, Galimberti M, Campus I, Conforti P, Cattaneo E.
Stem Cell Reports, 2020. 49:102016

New label-free methods for protein relative quantification applied to the investigation of an animal model of Huntington Disease
Cozzolino F, Landolfi A, Iacobucci I, Monaco V, Caterino M, Celentano S, Zuccato C, Cattaneo E, Monti M.
PLOS ONE, 2020. 15(9):e0238037.

MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome
Fasciani A, D’Annunzio S, Poli V, Fagnocchi L, Beyes S, Michelatti D, Corazza F, Antonelli L, Gregoretti F, Oliva G, Belli R, Peroni D, Domenici E, Zambrano S, Intartaglia D, Settembre C, Conte I, Testi C, Vergyris P, Ruocco G, Zippo A.
Nat Genet. 2020 Nov 9. doi: 10.1038/s41588-020-00724-8. Online ahead of print

P2X7 Receptor Activity Limits Accumulation of T Cells within Tumors
Romagnani A, Rottoli E, Mazza E, Rezzonico-Jost T, Ponte Conti B, Proietti M, Perotti M, Civanelli E, Perruzza L, Catapano A, Baragetti A, Tenedini E, Tagliafico E, Falzoni S, Di Virgilio F, Norata G, Bicciato S, Grassi F.
Cancer Res. 2020 Sep 15;80(18):3906-3919.

RUES2 hESCs exhibit MGE-biased neuronal differentiation and muHTT-dependent defective specification hinting at SP1
Conforti P, Besusso D, Brocchetti S, Campus I, Cappadona C, Galimberti M, Laporta A, Iennaco R, Rossi RL, Bocchi Dickinson V, Cattaneo E.
Neurobiology of Disease, Oct. 2020, doi.org/10.1016/j.nbd.2020.105140. In press.

FAM46C and FNDC3A are multiple myeloma tumor suppressors that act in concert to impair clearing of protein aggregates and autophagy
Manfrini N, Mancino M, Miluzio A, Oliveto S, Balestra M, Calamita P, Alfieri R, Rossi RL, Sassoè-Pognetto M, Salio C, Cuomo A, Bonaldi T, Manfredi M, Marengo E, Ranzato E, Martinotti S, Cittaro D, Tonon G, Biffo S.
Cancer Res. 2020 Sep 22;canres.1357.2020.

GADD34 is a modulator of autophagy during starvation
Gambardella G, Staiano L, Moretti MN, De Cegli R, Fagnocchi L, Di Tullio G, Polletti S, Braccia C, Armirotti A, Zippo A, Ballabio A, De Matteis MA, Di Bernardo D.
Sci Adv. 2020 Sep 25;6(39)

Frataxin gene editing rescues Friedreich’s ataxia pathology in dorsal root ganglia organoid-derived sensory neurons
Mazzara PG, Muggeo S, Luoni M, Massimino L, Zaghi M, Tajalli-Tehrani Valverde P, Brusco S, Marzi MJ, Palma C, Colasante G, Iannielli A, Paulis M, Cordiglieri C, Giannelli SG, Podini P, Gellera C, Taroni F, Nicassio F, Rasponi M, Broccoli V
Nat Commun. 2020 Aug 21;11(1):4178. doi:10.1038/s41467-020-17954-3

Single Myofiber Isolation and Culture from a Murine Model of Emery-Dreifuss Muscular Dystrophy in Early Post-Natal Development
Pegoli G, Lucini F, Mozzetta C and Lanzuolo C
JoVE. 2020; Published July 1, 2020

Nanoparticle‐Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment
Salvioni L, Zuppone S, Andreata F, Monieri M, Mazzucchelli S, Di Carlo C, Morelli L, Cordiglieri C, Donnici L,
De Francesco R, Corsi F, Prosperi D, Vago R, and Colombo M
Adv. Therap.  2000007

Extracellular Vesicles From Skeletal Muscle Cells Efficiently Promote Myogenesis in Induced Pluripotent Stem Cells
Baci D, Chirivì M, Pace V, Maiullari F, Milan M, Rampin A, Somma P, Presutti D, Garavelli S, Bruno A, Cannata S, Lanzuolo C, Gargioli C, Rizzi R, Bearzi C.
Cells, 2020 Jun 23: E1527

Intermittent β-adrenergic blockade downregulates the gene expression of β-myosin heavy chain in the mouse heart
Maccari S, Pace V, Barbagallo F, Stati T, Ambrosio C, Grò MC, Molinari P, Vezzi V, Catalano L, Matarrese P, Patrizio M, Rizzi R, Marano G.
Eur J Pharmacol.  Available on line 2020 Jun 22:173287. doi:10.1016/j.ejphar.2020.173287. In press.

Type III interferons disrupt the lung epithelial barrier upon viral recognition
Broggi A, Ghosh S, Sposito B, Spreafico R, Balzarini F, Lo Cascio A, Clementi N, De Santis M, Mancini N, Granucci F, Zanoni I.
Science. 2020 Jun 11:eabc3545. doi: 10.1126/science.abc3545

Profound Alterations of the Chromatin Architecture at Chromosome 11p15.5 in Cells From Beckwith-Wiedemann and Silver-Russell Syndromes Patients
Rovina D, La Vecchia M, Cortesi A, Fontana L, Pesant M, Maitz S, Tabano S, Bodega B, Miozzo M, Sirchia S
Sci Rep. 2020 May 19;10(1):8275.

IRF4 Instructs Effector Treg Differentiation and Immune Suppression in Human Cancer
Alvisi G, Brummelman J, Puccio S, Mazza E Mc, Paoluzzi Tomada E, Losurdo A, Zanon V, Peano C, Colombo F S, Scarpa A, Alloisio M, Vasanthakumar A, Roychoudhuri R, Kallikourdis M, Pagani M, Lopci E, Novellis P, Blume J, Kallies A, Veronesi G, Lugli E.
J Clin Invest. 2020 May 11;130426. Online ahead of print.

The Sophisticated Transcriptional Response Governed by Transposable Elements in Human Health and Disease
Marasca F, Gasparotto E, Polimeni B, Vadalà R , Ranzani V, Bodega B.
Int J Mol Sci. 2020 Apr 30;21(9):E3201.

OligoMinerApp: A Web-Server Application for the Design of Genome-Scale Oligonucleotide in Situ Hybridization Probes Through the Flexible OligoMiner Environment
Passaro M, Martinovic M, Bevilacqua V, Hershberg E A, Rossetti G, Beliveau B, Bonnal RJP, Pagani M.
Nucleic Acids Res. 2020 Apr 20;gkaa251. Online ahead of print.

Dysfunctional polycomb transcriptional repression contributes to Lamin A/C dependent muscular dystrophy
Bianchi A, Mozzetta C, Pegoli G, Lucini F, Valsoni S, Rosti V, Petrini C, Cortesi A, Gregoretti F, Antonelli L, Oliva G, De Bardi M, Rizzi R, Bodega B, Pasini D, Ferrari F, Bearzi C, Lanzuolo C
J Clin Invest. 2020; May 2020; 130(5):2408-2421.

Ribosome profiling unveils translational regulation of metabolic enzymes in primary CD4+ Th1 cells
Manfrini N, Ricciardi S, Alfieri R, Ventura G, Calamita P, Favalli A, Biffo S.
Dev Comp Immunol. 2020 Aug;109:103697. Epub 2020 Apr 21

The Endless Frontier? The Recent Increase of R&D Productivity in Pharmaceuticals
Pammolli F, Righetto L, Abrignani S, Pani L, Pelicci PG, Rabosio E.
J Transl Med, 2020 Apr 9;18(1):162.doi:10.1186/s1296-020-02313-z.

DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis
Thiruvalluvan A, de Mattos EP, Brunsting JF, Bakels R, Serlidaki D, Barazzuol L, Conforti P, Fatima A, Koyuncu S, Cattaneo E, Vilchez D, Bergink S, Boddeke E H W G, Copray S, Kampinga HH.
Mol Cell, 2020 Mar 25;S1097-2765(20)30115-5. doi:10.1016/j.molcel.2020.02.022. Online ahead of print.

Evidence for a pathogenic role of extrafollicular, IL-10–producing CCR6+B helper T cells in systemic lupus erythematosus
Facciotti F, Larghi P, Bosotti R, Vasco C, Gagliani N, Cordiglieri C, Mazzara S, Ranzani V, Rottoli E, Curti S, Penatti A, Karnani B, Kobayashi Y, Crosti M, Bombaci M, van Hamburg JP, Rossetti G, Gualtierotti R, Gerosa M, Gatti S, Torretta S, Pignataro L, Tas SW, Abrignani S, Pagani M, Grassi F, Meroni PL, Flavell RA, and Geginat J.
PNAS , March 17,2020; http://doi. org/10.1073/pnas.1917834117.

Immunological variables associated with clinical and endoscopic response to vedolizumab in patients with inflammatory bowel diseases.
Coletta M, Paroni M, Alvisi MF, De Luca M, Rulli E, Mazza S, Facciotti F, Lattanzi G, Strati F, Abrignani S, Fantini MC, Vecchi M, Geginat J, Caprioli F.
J Crohns Colitis. 2020 Feb 26. pii: jjaa035. doi: 10.1093/ecco-jcc/jjaa035. [Epub ahead of print]

High-dose vitamin C enhances cancer immunotherapy.
Magrì A, Germano G, Lorenzato A, Lamba S, Chilà R, Montone M, Amodio V, Ceruti T, Sassi F, Arena S, Abrignani S, D’Incalci M, Zucchetti M, Di Nicolantonio F, Bardelli A.
Sci Transl Med. 2020 Feb 26;12(532). pii: eaay8707. doi: 10.1126/scitranslmed.aay8707.

Cellular and molecular mechanisms of antifungal innate immunity at epithelial barriers: The role of C-type lectin receptors
Borriello F, Zanoni I, Granucci F.
Eur J Immunol. 2020 Mar; 50 (3):317-325. Epub 2020 Feb 6.

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells 
Marasca F, Cortesi A, Manganaro L, Bodega B.
J Vis Exp 2020 Jan 25;(155)

Tumor-Educated Platelets and Angiogenesis in Glioblastoma: Another Brick in the Wall for Novel Prognostic and Targetable Biomarkers, Changing the Vision from a Localized Tumor to a Systemic Pathology
Campanella R, Guarnaccia L, Cordiglieri C, Trombetta E, Caroli M, Carrabba G, La Verde N, Rampini P, Gaudino C, Costa A, Luzzi S, Mantovani G, Locatelli M, Riboni L, Navone SE and Marfia G.
Cells 2020, 9, 294; doi:10.3390/cells9020294. Published: 25 January 2020

Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits
Pesce E, Miluzio A, Turcano L, Minici C, Cirino D, Calamita P, Manfrini N, Oliveto S, Ricciardi S, Grifantini R, Degano M, Bresciani A, Biffo S.
Cells. 2020 Jan 10; 9(1):172.

A Structurally Simple Vaccine Candidate Reduces Progression and Dissemination of Triple-Negative Breast Cancer
Amedei A, Asadzadeh F, Papi F, Vannucchi MG, Ferrucci V, Bermejo I A, Fragai M, Vieira De Almeida C, Cerofolini L, Giuntini S, Bombaci M, Pesce E, Niccolai E, Natali F, Guarini E, Gabel F, Traini C, Catarinicchia S, Ricci F, Orzalesi L, Berti F, Corzana F, Zollo M, Grifantini R and Nativi C.
iScience. 2020 Jun 26; 23(6): 101250. Published online 2020 Jun 6

Efficacy of Cholesterol Nose-to-Brain Delivery for Brain Targeting in Huntington’s Disease.
Passoni A, Favagrossa M, Colombo L, Bagnati R, Gobbi M, Diomede L, Birolini G, Di Paolo E, Valenza M, Cattaneo E, Salmona M.
ACS Chem Neurosci. 2020 Feb 5;11(3):367-372. doi: 10.1021/acschemneuro.9b00581. Epub 2020 Jan 7

Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion
Broggi A, Granucci F, Zanoni I.
J Exp Med. 2020 Jan 6; 217(1):e20190295.

The induction and function of the anti-inflammatory fate of T H 17 cells
Xu H, Agalioti T, Zhao J, Steglich , Wahib R, Amezcua Vesely MC, Bielecki P, Bailis W, Jackson R, Perez D, Izbicki J, Licona-Limón P, Kaartinen V, Geginat J, Esplugues E, Tolosa E, Huber S, Flavell R, Gagliani N.
Nat Commun. 2020 Jul 3;11(1):3334.

Huntingtin gene CAG repeat size affects autism risk: Family-based and case-control association study.
Piras IS, Picinelli C, Iennaco R, Baccarin M, Castronovo P, Tomaiuolo P, Cucinotta F, Ricciardello A, Turriziani L, Nanetti L, Mariotti C, Gellera C, Lintas C, Sacco R, Zuccato C, Cattaneo E, Persico AM.
Am J Med Genet B Neuropsychiatr Genet. 2020 Sep;183(6):341-351.

Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease.
Besusso D, Schellino R, Boido M, Belloli S, Parolisi R, Conforti P, Faedo A, Cernigoj M, Campus I, Laporta A, Bocchi VD, Murtaj V, Parmar M, Spaiardi P, Talpo F, Maniezzi C, Toselli MG, Biella G, Moresco RM, Vercelli A, Buffo A, Cattaneo E.
Stem Cell Reports. 2020 May 12;14(5):876-891.

Inflammatory interactions between degenerated intervertebral discs and microglia: Implication of sphingosine-1-phosphate signaling
Navone S, Campanella R, Guarnaccia L, Ouellet JA, Locatelli M, Cordiglieri C, Gualtierotti R, Gaudino C, Ciniglio Appiani G, Luzzi S, Borsa S, Rampini P, Pluderi M, Haglund L, Riboni L, Alini M, Marfia G.
J Orthop Res. 2020 Aug 11. doi: 10.1002/jor.24827.

Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses
Iannielli A, Ugolini GS, Cordiglieri C, et al.
Cell Rep. 2019;29(13):4646–4656.e4.

A subset of colorectal cancers with cross-sensitivity to olaparib and oxaliplatin
Arena S, Corti G, Durinikova E, Montone M, Reilly NM, Russo M, Lorenzato A, Arcella P, Lazzari L, Rospo G, Pagani M1, Cancelliere C, Negrino C, Isella C, Bartolini A, Cassingena A, Amatu A, Mauri G, Sartore-Bianchi A, Mittica G, Medico E, Marsoni S, Linnebacher M, Abrignani S, Siena S, Di Nicolantonio F, Bardelli A.
Clinical Cancer Research, 2019 Dec 12. pii: clincanres.2409.2019. doi: 10.1158/1078-0432.CCR-19-2409. [Epub ahead of print]

IL-10 producing regulatory and helper T-cells in systemic lupus erythematosus.
Geginat J, Vasco M, Gerosa M, Tas SW, Pagani M, Grassi F, Flavell RA, Meroni P, Abrignani S.
Semin Immunol. 2019 Aug;44:101330.

Introduction to the Special Issue: Interleukin-10 “The surprising twists and turns of an anti-inflammatory cytokine on its way to the clinic”.
Geginat J.
Semin Immunol. 2019 Aug;44:101343.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
Cossarizza A. et al.
Eur J Immunol. 2019 Oct;49(10):1457-1973.

Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis.
López-Tobón A, Villa CE, Cheroni C, Trattaro S, Caporale N, Conforti P, Iennaco R, Lachgar M, Rigoli MT, Marcó de la Cruz B, Lo Riso P, Tenderini E, Troglio F, De Simone M, Liste-Noya I, Macino G, Pagani M, Cattaneo E, Testa G.
Stem Cell Reports. 2019 Oct 1. pii: S2213-6711(19)30334-0. [Epub ahead of print]

TNF-Stimulated Gene-6 Is a Key Regulator in Switching Stemness and Biological Properties of Mesenchymal Stem Cells.
Romano B, Elangovan S, Erreni M, Sala E, Petti L, Kunderfranco P, Massimino L, Restelli S,3, Sinha S, Lucchetti D, Anselmo A, Colombo FS, Stravalaci M, Arena V, D’Alessio S, Ungaro F, Inforzato A, Izzo AA, Sgambato A, Day AJ, Vetrano S.
Stem Cells. 2019; doi: 10.1002/stem.3010. [Epub ahead of print]

Chromium 10× Single-Cell 3′ mRNA Sequencing of Tumor-Infiltrating Lymphocytes
De Simone M, Rossetti G, Pagani M.
Methods Mol Biol. 2019;1979:87-110.

Computation and Selection of Optimal Biomarker Combinations by Integrative ROC Analysis Using CombiROC.
Bombaci M, Rossi RL.
Methods Mol Biol. (2019);1959:247-259.

Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease.
Pelusi S, Baselli G, Pietrelli A, Dongiovanni P, Donati B, McCain MV, Meroni M, Fracanzani AL, Romagnoli R, Petta S, Grieco A, Miele L, Soardo G, Bugianesi E, Fargion S, Aghemo A, D’Ambrosio R, Xing C, Romeo S, De Francesco R, Reeves HL, Valenti LVC.
Sci Rep. 2019 Mar 6;9(1):3682.

A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomes.
Bertolini I, Terrasi A, Martelli C, Gaudioso G, Di Cristofori A, Storaci AM, Formica M, Braidotti P, Todoerti K, Ferrero S, Caroli M, Ottobrini L, Vaccari T, Vaira V
EBioMedicine. 2019 Feb 5. pii: S2352-3964(19)30059-3. doi: 10.1016/j.ebiom.2019.01.051. [Epub ahead of print]

Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo.
Terrasi A, Bertolini I, Martelli C, Gaudioso G, Di Cristofori A, Storaci AM, Formica M, Bosari S, Caroli M, Ottobrini L, Vaccari T, Vaira V.
EBioMedicine. 2019 Feb 5. pii: S2352-3964(19)30058-1. doi: 10.1016/j.ebiom.2019.01.052. [Epub ahead of print]

NIPBL: a new player in myeloid cells differentiation.
Mazzola M, Deflorian G, Pezzotta A, Ferrari L, Fazio G, Bresciani E, Saitta C, Ferrari L, Fumagalli M, Parma M, Marasca F, Bodega B, Riva P, Cotelli F, Biondi A, Marozzi A, Cazzaniga G, Pistocchi A
Haematologica. 2019 Jan 10. pii: haematol.2018.200899. doi: 10.3324/haematol.2018.200899. [Epub ahead of print]

P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus.
Faliti CE, Gualtierotti R, Rottoli E, Gerosa M, Perruzza L, Romagnani A, Pellegrini G, De Ponte Conti B, Rossi RL, Idzko M, Mazza EMC, Bicciato S, Traggiai E, Meroni PL, Grassi F
J Exp Med. 2019 Jan 17. pii: jem.20171976. doi: 10.1084/jem.20171976. [Epub ahead of print]

ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens.
Proietti M, Perruzza L, Scribano D, Pellegrini G, D’Antuono R, Strati F, Raffaelli M, Gonzalez SF, Thelen M, Hardt WD, Slack E, Nicoletti M, Grassi F.
Nat Commun. 2019 Jan 16;10(1):250.

 

Eomesodermin controls a unique differentiation program in human IL-10 and IFN-γ co-producing regulatory T-cells.
Gruarin P, Maglie S, De Simone M, Häringer B, Vasco C, Ranzani V, Bosotti R, Noddings JS, Larghi P, Facciotti F, Sarnicola ML, Martinovic M, Crosti MC, Moro M, Rossi RL, Bernardo ME, Caprioli F, Locatelli F, Rossetti G, Abrignani S, Pagani M, Geginat J
Eur J Immunol. 2018 Nov 15. [Epub ahead of print]

Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease.
Zhang B, Watt JM, Cordiglieri C, Dammermann W, Mahon MF, Flügel A, Guse AH, Potter BVL
Sci Rep. (2018); 13;8(1):16775.

Aspirin Affects Tumor Angiogenesis and Sensitizes Human Glioblastoma Endothelial Cells to Temozolomide, Bevacizumab, and Sunitinib, Impairing Vascular Endothelial Growth Factor-Related Signaling.
Navone SE1 Guarnaccia L, Cordiglieri C, Crisà FM, Caroli M, Locatelli M, Schisano L, Rampini P, Miozzo M, La Verde N, Riboni L, Campanella R, Marfia G.
World Neurosurg. (2018); Aug 23. pii: S1878-8750(18)31863-1.

Angiogenesis in human brain tumors: screening of drug response through a patient-specific cell platform for personalized therapy.
Guarnaccia L, Navone SE, Trombetta E, Cordiglieri C, Cherubini A, Crisà FM, Rampini P, Miozzo M, Fontana L, Caroli M, Locatelli M, Riboni L, Campanella R, Marfia G
Sci Rep. (2018); 8(1):8748.

IL-15 regulates susceptibility of CD4+ T cells to HIV infection.
Manganaro L, Hong P, Hernandez MM, Argyle D, Mulder LCF, Potla U, Diaz-Griffero F, Lee B, Fernandez-Sesma A, Simon V.
Proc Natl Acad Sci U S A (2018) 115:E9659-E9667

RACK1 Specifically Regulates Translation through its Binding to Ribosomes.
Gallo S, Ricciardi S, Manfrini N, Pesce E, Oliveto S, Calamita P, Mancino M, Maffioli E, Moro M, Crosti M, Berno V, Bombaci M, Tedeschi G, Biffo S
Mol Cell Biol. (2018) pii: MCB.00230-18. 

Low-affinity Nerve Growth Factor Receptor (CD271) Heterogeneous Expression in Adult and Fetal Mesenchymal Stromal Cells.
Barilani M, Banfi F, Sironi S, Ragni E, Guillaumin S, Polveraccio F, Rosso L, Moro M, Astori G, Pozzobon M, Lazzari L
Sci Rep. (2018); 8(1):9321. 

The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling.
Ricciardi S, Manfrini N, Alfieri R, Calamita P, Crosti MC, Simone G, Müller R, Pagani M, Abrignani S, Biffo S.
Cell Metab. (2018) Aug 29. pii: S1550-4131(18)30510-2.  [Epub ahead of print]

A polysome-based microRNA screen identifies miR-24-3p as a novel pro-migratory miRNA in mesothelioma.
Oliveto S, Alfieri R, Miluzio A, Scagliola A, Seclì RS, Gasparini P, Grosso S, Cascione L, Mutti L, Biffo S.
Cancer Res. (2018) pii: canres.0655.2018 [Epub ahead of print]

Single Cell T Cell Receptor Sequencing: Techniques and Future Challenges.
De Simone M, Rossetti G, Pagani M.
Front Immunol. (2018) 9:1638

Big Data: Challenge and Opportunity for Translational and Industrial Research
Rossi RL, Grifantini RM.
Front. Digit. Humanit. (2018) 5:13. doi: 10.3389/fdigh.2018.00013

Exploring the links between cancer and placenta development
Costanzo V, Bardelli A, Siena S, Abrignani S.
Open Biology (2018) rsob.180081 

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth.
Pacella I, Procaccini C, Focaccetti C, Miacci S, Timperi E, Faicchia D, Severa M, Rizzo F, Coccia EM, Bonacina F, Mitro N, Norata GD, Rossetti G, Ranzani V, Pagani M, Giorda E, Wei Y, Matarese G, Barnaba V, Piconese S.
Proc Natl Acad Sci U S A. (2018) pii: 201720113

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity.
Wang D, Quiros J, Mahuron K, Pai CC, Ranzani V, Young A, Silveria S, Harwin T, Abnousian A, Pagani M, Rosenblum MD, Van Gool F, Fong L, Bluestone JA, DuPage M.
Cell Rep. (2018) 23(11):3262-3274

Elevated TGF β2 serum levels in Emery-Dreifuss Muscular Dystrophy: Implications for myocyte and tenocyte differentiation and fibrogenic processes.
Bernasconi P, Carboni N, Ricci G, Siciliano G, Politano L, Maggi L, Mongini T, Vercelli L, Rodolico C, Biagini E, Boriani G, Ruggiero L, Santoro L, Schena E, Prencipe S, Evangelisti C, Pegoraro E, Morandi L, Columbaro M, Lanzuolo C, Sabatelli P, Cavalcante P, Cappelletti C, Bonne G, Muchir A, Lattanzi G.
Nucleus. (2018) 9(1):292-304.

Mechanical loading of intervertebral disc modulates microglia proliferation, activation, and chemotaxis.
Navone SE, Peroglio M, Guarnaccia L, Beretta M, Grad S, Paroni M, Cordiglieri C, Locatelli M, Pluderi M, Rampini P, Campanella R, Alini M, Marfia G
Osteoarthritis Cartilage. (2018) May 1. pii: S1063-4584(18)31220-2

Mechanotransduction, nuclear architecture and epigenetics in Emery Dreifuss Muscular Dystrophy: tous pour un, un pour tous.
Bianchi A, Manti PG, Lucini F, Lanzuolo C.
Nucleus. (2018) 1;9:276-290

A Mad2-Mediated Translational Regulatory Mechanism Promoting S-Phase Cyclin Synthesis Controls Origin Firing and Survival to Replication Stress.
Gay S, Piccini D, Bruhn C, Ricciardi S, Soffientini P, Carotenuto W, Biffo S, Foiani M.
Mol Cell. (2018) 70(4):628-638

Magnetically driven drug delivery systems improving targeted immunotherapy for colon-rectal cancer.
Grifantini R, Taranta M, Gherardini L, Naldi I, Parri M, Grandi A, Giannetti A, Tombelli S, Lucarini G, Ricotti L, Campagnoli S, De Camilli E, Pelosi G, Baldini F, Menciassi A, Viale G, Pileri P, Cinti C.
J Control Release (2018) pii: S0168-3659(18)30254-2

Enhancer reprogramming in tumor progression: a new route towards cancer cell plasticity.
Fagnocchi L, Poli V, Zippo A.
Cell Mol Life Science (2018) s00018-018-2820-1

Pathogenicity of in-vivo generated intestinal Th17 lymphocytes is IFNγ dependent.
Nizzoli G, Burrello C, Cribiù FM, Lovati G, Ercoli G, Botti F, Trombetta E, Porretti L, Todoerti K, Neri A, Giuffrè MR, Geginat J, Vecchi M, Rescigno M, Paroni M, Caprioli F, Facciotti F.
J Crohns Colitis (2018) ecco-jcc/jjy051 

Dynamic and Cell-Specific DACH1 Expression in Human Neocortical and Striatal Development.
Castiglioni V, Faedo A, Onorati M, Bocchi VD, Li Z, Iennaco R, Vuono R, Bulfamante GP, Muzio L, Martino G, Sestan N, Barker RA, Cattaneo E.
Cerebral Cortex (2018) cercor/bhy092 

Sumoylation and ubiquitylation crosstalk in the control of ΔNp63α protein stability.
Ranieri M, Vivo M, De Simone M, Guerrini L, Pollice A, La Mantia G, Calabrò V.
Gene (2018) 645:34-40

Enhancing Antibody Serodiagnosis Using a Controlled Peptide Coimmobilization Strategy.
Sola L, Gagni P, D’Annessa I, Capelli R, Bertino C, Romanato A, Damin F, Bergamaschi G, Marchisio E, Cuzzocrea A, Bombaci M, Grifantini R, Chiari M, Colombo G, Gori A, Cretich M.
ACS Infect Dis (2018) 8b00014

How Polycomb-Mediated Cell Memory Deals With a Changing Environment: Variations in PcG complexes and proteins assortment convey plasticity to epigenetic regulation as a response to environment.
Marasca F, Bodega B, Orlando V.
Bioessays. (2018) 40(4):e1700137

Modulation of innate and adaptive immunity by P2X ion channels.
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Successful sequential therapy with rituximab and belimumab in patients with active systemic lupus erythematosus: a case series.
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MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state.
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Intestinal IFN-γ-producing Tr1-cells co-express CCR5 and PD-1, and down-regulate IL-10 in the inflamed gut of IBD patients.
Alfen JS, Larghi P, Facciotti F, Gagliani N, Bosotti R, Paroni M, Maglie S, Gruarin P, Vasco CM, Ranzani V, Frusteri C, Iseppon A, Moro M, Crosti MC, Gatti S, Pagani M, Caprioli F, Abrignani S, Flavell RA, Geginat J.
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Lack of Methyl-CpG Binding Protein 2 (MeCP2) Affects Cell Fate Refinement During Embryonic Cortical Development.
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Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes.
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Proc Natl Acad Sci U S A. (2018) 115(4):E762-E771

myVCF: a desktop application for high-throughput mutations data management.
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TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut.
Romagnani A, Vettore V, Rezzonico-Jost T, Hampe S, Rottoli E, Nadolni W, Perotti M, Meier MA, Hermanns C, Geiger S, Wennemuth G, Recordati C, Matsushita M, Muehlich S, Proietti M, Chubanov V, Gudermann T, Grassi F, Zierler S.
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TCTN2: a novel tumor marker with oncogenic properties.
Cano-Rodriguez D, Campagnoli S, Grandi A, Parri M, Camilli E, Song C, Jin B, Lacombe A, Pierleoni A, Bombaci M, Cordiglieri C, Ruiters MH, Viale G, Terracciano L, Sarmientos P, Abrignani S, Grandi G, Pileri P, Rots MG, Grifantini R.
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Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation.
Cariulo C, Azzollini L, Verani M, Martufi P, Boggio R, Chiki A, Deguire SM, Cherubini M, Gines S, Marsh JL, Conforti P, Cattaneo E, Santimone I, Squitieri F, Lashuel HA, Petricca L, Caricasole A
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Crosstalks between translation and metabolism in cancer.
Biffo S, Manfrini N, Ricciardi S.
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FGF2 and EGF Are Required for Self-Renewal and Organoid Formation of Canine Normal and Tumor Breast Stem Cells.

Cocola C, Molgora S, Piscitelli E, Veronesi MC, Greco M, Bragato C, Moro M, Crosti M, Gray B, Milanesi L, Grieco V, Luvoni GC, Kehler J, Bellipanni G, Reinbold R, Zucchi I, Giordano A
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The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks.
Clarke K, Ricciardi S, Pearson T, Bharudin I, Davidsen PK, Bonomo M, Brina D, Scagliola A, Simpson DM, Beynon RJ, Khanim F, Ankers J, Sarzynski MA, Ghosh S, Pisconti A, Rozman J, Hrabe de Angelis M, Bunce C, Stewart C, Egginton S, Caddick M, Jackson M, Bouchard C, Biffo S, Falciani F
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Guidelines for the use of flow cytometry and cell sorting in immunological studies.
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Eur J Immunol (2017) 47:1584-1797

Repression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells.
Ripamonti A, Provasi E, Lorenzo M, De Simone M, Ranzani V, Vangelisti S, Curti S, Bonnal RJP, Pignataro L, Torretta S, Geginat J, Rossetti G, Pagani M, Abrignani S.
Proc Natl Acad Sci U S A. (2017) 114:12797-12802

Maintenance of memory CD8 T cells: Divided over division.
Nolte MA, Goedhart M, Geginat J.
Eur J Immunol. (2017) 47:1875-1879

CD4+ T Helper Cell Plasticity in Infection, Inflammation, and Autoimmunity.
Huber S, Gagliani N, O’Connor W Jr, Geginat J, Caprioli F.
Mediators Inflamm. 2017;2017:7083153

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.
Benzine T, Brandt R, Lovell WC, Yamane D, Neddermann P, De Francesco R, Lemon SM, Perelson AS, Ke R, McGivern DR.
PLoS Pathog (2017) 13:e1006343

A cytosolic Ezh1 isoform modulates a PRC2-Ezh1 epigenetic adaptive response in postmitotic cells.
Bodega B, Marasca F, Ranzani V, Cherubini A, Della Valle F, Neguembor MV, Wassef M, Zippo A, Lanzuolo C, Pagani M, Orlando V.
Nat Struct Mol Biol (2017) 24:444-452

SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention.
Calamita P, Miluzio A, Russo A, Pesce E, Ricciardi S, Khanim F, Cheroni C, Alfieri R, Mancino M, Gorrini C, Rossetti G, Peluso I, Pagani M, Medina DL, Rommens J, Biffo S.
PLoS Genet (2017) 13:e1006552

Improvement of ALT decay kinetics by all-oral HCV treatment: Role of NS5A inhibitors and differences with IFN-based regimens.
Cento V, Nguyen THT, Di Carlo D, Biliotti E, Gianserra L, Lenci I, Di Paolo D, Calvaruso V, Teti E, Cerrone M, Romagnoli D, Melis M, Danieli E, Menzaghi B, Polilli E, Siciliano M, Nicolini LA, Di Biagio A, Magni CF, Bolis M, Antonucci FP, Di Maio VC, Alfieri R, Sarmati L, Casalino P, Bernardini S, Micheli V, Rizzardini G, Parruti G, Quirino T, Puoti M, Babudieri S, D’Arminio Monforte A, Andreoni M, Craxi A, Angelico M, Pasquazzi C, Taliani G, Guedj J, Perno CF, Ceccherini-Silberstein F.
PLoS One (2017) 12:e0177352

Eukaryotic initiation factor eIF6 modulates the expression of Kermit 2/XGIPC in IGF- regulated eye development.
De Marco N, Tussellino M, Carotenuto R, Ronca R, Rizzolio S, Biffo S, Campanella C.
Dev Biol (2017) 427:148-154

Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease.
Donati B, Pietrelli A, Pingitore P, Dongiovanni P, Caddeo A, Walker L, Baselli G, Pelusi S, Rosso C, Vanni E, Daly A, Mancina RM, Grieco A, Miele L, Grimaudo S, Craxi A, Petta S, De Luca L, Maier S, Soardo G, Bugianesi E, Colli F, Romagnoli R, Anstee QM, Reeves HL, Fracanzani AL, Fargion S, Romeo S, Valenti L.
Cancer Med (2017) 6:1930-1940

Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
Dongiovanni P, Meroni M, Baselli GA, Bassani GA, Rametta R, Pietrelli A, Maggioni M, Facciotti F, Trunzo V, Badiali S, Fargion S, Gatti S, Valenti L.
Clin Sci (Lond) (2017) 131:1301-1315

Differentiation of human telencephalic progenitor cells into MSNs by inducible expression of Gsx2 and Ebf1.
Faedo A, Laporta A, Segnali A, Galimberti M, Besusso D, Cesana E, Belloli S, Moresco RM, Tropiano M, Fuca E, Wild S, Bosio A, Vercelli AE, Biella G, Cattaneo E.
Proc Natl Acad Sci U S A (2017) 114:E1234-E1242

Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells.
Fagnocchi L, Zippo A.
Front Cell Dev Biol (2017) 5:7

MicroRNA-26a/cyclin-dependent kinase 5 axis controls proliferation, apoptosis and in vivo tumor growth of diffuse large B-cell lymphoma cell lines.
Farina FM, Inguscio A, Kunderfranco P, Cortesi A, Elia L, Quintavalle M.
Cell Death Dis (2017) 8:e2890

Lack of evidence for post-vaccine onset of autoimmune/lymphoproliferative disorders, during a nine-month follow-up in multiply vaccinated Italian military personnel.
Ferlito C, Barnaba V, Abrignani S, Bombaci M, Sette A, Sidney J, Biselli R, Tomao E, Cattaruzza MS, Germano V, Biondo MI, Salerno G, Lulli P, Caporuscio S, Picchianti Diamanti A, Falco M, Biselli V, Cardelli P, Autore A, Lucertini E, De Cesare DP, Peragallo MS, Lista F, Martire C, Salemi S, Nisini R, D’Amelio R.
Clin Immunol (2017) 181:60-66

Immunological phenotype of the murine Lrba knockout.
Gamez-Diaz L, Neumann J, Jager F, Proietti M, Felber F, Soulas-Sprauel P, Perruzza L, Grassi F, Kogl T, Aichele P, Kilimann M, Grimbacher B, Jung S.
Immunol Cell Biol (2017) 95:789-802

The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?
Geginat J, Paroni M, Pagani M, Galimberti D, De Francesco R, Scarpini E, Abrignani S.
Trends Immunol (2017) 38:498-512

Purification of LAT-Containing Membranes from Resting and Activated T Lymphocytes.
Hivroz C, Larghi P, Jouve M, Ardouin L.
Methods Mol Biol (2017) 1584:355-368

The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets.
Iaconis D, Monti M, Renda M, van Koppen A, Tammaro R, Chiaravalli M, Cozzolino F, Pignata P, Crina C, Pucci P, Boletta A, Belcastro V, Giles RH, Surace EM, Gallo S, Pende M, Franco B.
Sci Rep (2017) 7:1224

Analysis of T Cell Activation by Confocal Microscopy.
Larghi P, Viola A, Molon B.
Methods Mol Biol (2017) 1514:63-81

Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation.
Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Adler T, Busch DH, Gailus-Durner V, Fuchs H, de Angelis MH, Biffo S.
Data Brief (2017) 14:653-658

High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans.
Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Brina D, Adler T, Busch DH, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Biffo S.
Dev Comp Immunol (2017) 77:69-76

CombiROC: an interactive web tool for selecting accurate marker combinations of omics data.
Mazzara S, Rossi RL, Grifantini R, Donizetti S, Abrignani S, Bombaci M.
Sci Rep (2017) 7:45477

Filamin A is reduced and contributes to the CASR sensitivity in human parathyroid tumors.
Mingione A, Verdelli C, Ferrero S, Vaira V, Guarnieri V, Scillitani A, Vicentini L, Balza G, Beretta E, Terranegra A, Vezzoli G, Soldati L, Corbetta S.
J Mol Endocrinol (2017) 58:91-103

Role of microRNAs in translation regulation and cancer.
Oliveto S, Mancino M, Manfrini N, Biffo S.
World J Biol Chem (2017) 8:45-56

Recognition of viral and self-antigens by TH1 and TH1/TH17 central memory cells in patients with multiple sclerosis reveals distinct roles in immune surveillance and relapses.
Paroni M, Maltese V, De Simone M, Ranzani V, Larghi P, Fenoglio C, Pietroboni AM, De Riz MA, Crosti MC, Maglie S, Moro M, Caprioli F, Rossi R, Rossetti G, Galimberti D, Pagani M, Scarpini E, Abrignani S, Geginat J.
J Allergy Clin Immunol (2017) 140:797-808

Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis.
Penatti A, Facciotti F, De Matteis R, Larghi P, Paroni M, Murgo A, De Lucia O, Pagani M, Pierannunzii L, Truzzi M, Ioan-Facsinay A, Abrignani S, Geginat J, Meroni PL.
Arthritis Res Ther (2017) 19:103

T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP.
Perruzza L, Gargari G, Proietti M, Fosso B, D’Erchia AM, Faliti CE, Rezzonico-Jost T, Scribano D, Mauri L, Colombo D, Pellegrini G, Moregola A, Mooser C, Pesole G, Nicoletti M, Norata GD, Geuking MB, McCoy KD, Guglielmetti S, Grassi F.
Cell Rep (2017) 18:2566-2575

Dopamine receptor type 2 (DRD2) and somatostatin receptor type 2 (SSTR2) agonists are effective in inhibiting proliferation of progenitor/stem-like cells isolated from nonfunctioning pituitary tumors.
Peverelli E, Giardino E, Treppiedi D, Meregalli M, Belicchi M, Vaira V, Corbetta S, Verdelli C, Verrua E, Serban AL, Locatelli M, Carrabba G, Gaudenzi G, Malchiodi E, Cassinelli L, Lania AG, Ferrero S, Bosari S, Vitale G, Torrente Y, Spada A, Mantovani G.
Int J Cancer (2017) 140:1870-1880

Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression.
Poli A, Fiume R, Baldanzi G, Capello D, Ratti S, Gesi M, Manzoli L, Graziani A, Suh PG, Cocco L, Follo MY.
J Cell Physiol (2017) 232:2550-2557

Nuclear translocation of PKC-alpha is associated with cell cycle arrest and erythroid differentiation in myelodysplastic syndromes (MDSs).
Poli A, Ratti S, Finelli C, Mongiorgi S, Clissa C, Lonetti A, Cappellini A, Catozzi A, Barraco M, Suh PG, Manzoli L, McCubrey JA, Cocco L, Follo MY.
FASEB J (2017)

Next-Generation Sequencing Analysis of Long Noncoding RNAs in CD4+ T Cell Differentiation.
Ranzani V, Arrigoni A, Rossetti G, Panzeri I, Abrignani S, Bonnal RJ, Pagani M.
Methods Mol Biol (2017) 1514:173-185

Human macrophage ferroportin biology and the basis for the ferroportin disease.
Sabelli M, Montosi G, Garuti C, Caleffi A, Oliveto S, Biffo S, Pietrangelo A.
Hepatology (2017) 65:1512-1525

Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity.
Torri A, Carpi D, Bulgheroni E, Crosti MC, Moro M, Gruarin P, Rossi RL, Rossetti G, Di Vizio D, Hoxha M, Bollati V, Gagliani C, Tacchetti C, Paroni M, Geginat J, Corti L, Venegoni L, Berti E, Pagani M, Matarese G, Abrignani S, de Candia P.
J Biol Chem (2017) 292:2903-2915

 

 

 

 

 

miR-17∼92 family clusters control iNKT cell ontogenesis via modulation of TGF-β signaling.
Fedeli M, Riba M, Garcia Manteiga JM, Tian L, Viganò V, Rossetti G, Pagani M, Xiao C, Liston A, Stupka E, Cittaro D, Abrignani S, Provero P, Dellabona P, Casorati G
Proc Natl Acad Sci U S A. (2016). 113(51):E8286-E8295.

 

The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery.
Stunnenberg HG; International Human Epigenome Consortium, Hirst M.
Cell. (2016); 167(7):1897.

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.
Bedogni F, Cobolli Gigli C, Pozzi D, Rossi RL, Scaramuzza L, Rossetti G, Pagani M, Kilstrup-Nielsen C, Matteoli M, Landsberger N.
Cereb Cortex. (2016). (6):2517-2529.

In-Vivo Validation of Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism.
Baj-Rossi C, Cavallini A, Kilinc EG, Stradolini F, Rezzonico Jost T, Proietti M, De Micheli G, Grassi F, Dehollain C, Carrara S.
IEEE Trans Biomed Circuits Syst. (2016) doi: 10.1109/TBCAS.2016.2584239. [Epub ahead of print]

Determination of Polycomb Group of Protein Compartmentalization Through Chromatin Fractionation Procedure.
Marasca F, Marullo F, Lanzuolo C
Methods Mol Biol. (2016);1480:167-80.

Analysis RNA-seq and Noncoding RNA.
Arrigoni A, Ranzani V, Rossetti G, Panzeri I, Abrignani S, Bonnal RJ, Pagani M.
Methods Mol Biol (2016) 1480:125-35

FALDO: a semantic standard for describing the location of nucleotide and protein feature annotation.
Bolleman JT, Mungall CJ, Strozzi F, Baran J, Dumontier M, Bonnal RJ, Buels R, Hoehndorf R, Fujisawa T, Katayama T, Cock PJ.
J Biomed Semantics (2016) 7:39

DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection.
Burza MA, Motta BM, Mancina RM, Pingitore P, Pirazzi C, Lepore SM, Spagnuolo R, Doldo P, Russo C, Lazzaro V, Fischer J, Berg T, Aghemo A, Cheroni C, De Francesco R, Fargion S, Colombo M, Datz C, Stickel F, Valenti L, Romeo S.
Hepatology (2016) 63:418-27

A neuronal network of mitochondrial dynamics regulates metastasis.
Caino MC, Seo JH, Aguinaldo A, Wait E, Bryant KG, Kossenkov AV, Hayden JE, Vaira V, Morotti A, Ferrero S, Bosari S, Gabrilovich DI, Languino LR, Cohen AR, Altieri DC.
Nat Commun (2016) 7:13730

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.
Chae YC, Vaira V, Caino MC, Tang HY, Seo JH, Kossenkov AV, Ottobrini L, Martelli C, Lucignani G, Bertolini I, Locatelli M, Bryant KG, Ghosh JC, Lisanti S, Ku B, Bosari S, Languino LR, Speicher DW, Altieri DC.
Cancer Cell (2016) 30:257-272

Fluorescence Resonance Energy Transfer Microscopy for Measuring Chromatin Complex Structure and Dynamics.
Cherubini A, Zippo A.
Methods Mol Biol (2016) 1480:143-52

The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells.
Chiaruttini G, Piperno GM, Jouve M, De Nardi F, Larghi P, Peden AA, Baj G, Muller S, Valitutti S, Galli T, Benvenuti F.
Cell Rep (2016) 14:2624-36

Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer.
Ciardiello C, Cavallini L, Spinelli C, Yang J, Reis-Sobreiro M, de Candia P, Minciacchi VR, Di Vizio D.
Int J Mol Sci (2016) 17:175

Chromosome Conformation Capture in Primary Human Cells.
Cortesi A, Bodega B.
Methods Mol Biol (2016) 1480:213-21

The circulating microRNome demonstrates distinct lymphocyte subset-dependent signatures.
de Candia P, Torri A, Fedeli M, Vigano V, Carpi D, Gorletta T, Casorati G, Pagani M, Dellabona P, Abrignani S.
Eur J Immunol (2016) 46:725-31

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells.
De Simone M, Arrigoni A, Rossetti G, Gruarin P, Ranzani V, Politano C, Bonnal RJ, Provasi E, Sarnicola ML, Panzeri I, Moro M, Crosti M, Mazzara S, Vaira V, Bosari S, Palleschi A, Santambrogio L, Bovo G, Zucchini N, Totis M, Gianotti L, Cesana G, Perego RA, Maroni N, Pisani Ceretti A, Opocher E, De Francesco R, Geginat J, Stunnenberg HG, Abrignani S, Pagani M.
Immunity (2016) 45:1135-1147

Analysis of NSCLC tumour heterogeneity, proliferative and 18F-FDG PET indices reveals Ki67 prognostic role in adenocarcinomas.
Del Gobbo A, Pellegrinelli A, Gaudioso G, Castellani M, Zito Marino F, Franco R, Palleschi A, Nosotti M, Bosari S, Vaira V, Ferrero S.
Histopathology (2016) 68:746-51

Phosphoinositides in the nucleus and myogenic differentiation: how a nuclear turtle with a PHD builds muscle.
Divecha N.
Biochem Soc Trans (2016) 44:299-306

The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage.
Donati B, Motta BM, Pingitore P, Meroni M, Pietrelli A, Alisi A, Petta S, Xing C, Dongiovanni P, del Menico B, Rametta R, Mancina RM, Badiali S, Fracanzani AL, Craxi A, Fargion S, Nobili V, Romeo S, Valenti L.
Hepatology (2016) 63:787-98

Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIalpha and Oxysterol-Binding Protein.
Dorobantu CM, Albulescu L, Lyoo H, van Kampen M, De Francesco R, Lohmann V, Harak C, van der Schaar HM, Strating JR, Gorbalenya AE, van Kuppeveld FJ.
mSphere (2016) 1

IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus.
Facciotti F, Gagliani N, Haringer B, Alfen JS, Penatti A, Maglie S, Paroni M, Iseppon A, Moro M, Crosti MC, Stolzel K, Romagnani C, Moroni G, Ingegnoli F, Torretta S, Pignataro L, Annoni A, Russo F, Pagani M, Abrignani S, Meroni P, Flavell R, Geginat J.
J Allergy Clin Immunol (2016) 137:318-321 e5

A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity.
Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, Berno V, Rossi RL, Reinbold R, Endele M, Schroeder T, Rocchigiani M, Szkarlat Z, Oliviero S, Dalton S, Zippo A.
Nat Commun (2016) 7:11903

Integration of Signaling Pathways with the Epigenetic Machinery in the Maintenance of Stem Cells.
Fagnocchi L, Mazzoleni S, Zippo A.
Stem Cells Int (2016) 2016:8652748

Ectonucleotidase activity and immunosuppression in astrocyte-CD4 T cell bidirectional signaling.
Filipello F, Pozzi D, Proietti M, Romagnani A, Mazzitelli S, Matteoli M, Verderio C, Grassi F.
Oncotarget (2016) 7:5143-56

PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis.
Fiume R, Jones DR, Divecha N.
Trends Biochem Sci (2016) 41:473-475

The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer.
Geginat J, Larghi P, Paroni M, Nizzoli G, Penatti A, Pagani M, Gagliani N, Meroni P, Abrignani S, Flavell RA.
Cytokine Growth Factor Rev (2016) 30:87-93

Reverse plasticity: TGF-beta and IL-6 induce Th1-to-Th17-cell transdifferentiation in the gut.
Geginat J, Paroni M, Kastirr I, Larghi P, Pagani M, Abrignani S.
Eur J Immunol (2016) 46:2306-2310

ERMP1, a novel potential oncogene involved in UPR and oxidative stress defense, is highly expressed in human cancer.
Grandi A, Santi A, Campagnoli S, Parri M, De Camilli E, Song C, Jin B, Lacombe A, Castori-Eppenberger S, Sarmientos P, Grandi G, Viale G, Terracciano L, Chiarugi P, Pileri P, Grifantini R.
Oncotarget (2016) 7:63596-63610

An Automatic Segmentation Method Combining an Active Contour Model and a Classification Technique for Detecting Polycomb-group Proteinsin High-Throughput Microscopy Images.
Gregoretti F, Cesarini E, Lanzuolo C, Oliva G, Antonelli L.
Methods Mol Biol (2016) 1480:181-97

Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.
Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Vondran FW, De Francesco R, Rice CM, Bartenschlager R, Lohmann V.
Nat Microbiol (2016) 2:16247

Role of CXCR4-mediated bone marrow colonization in CNS infiltration by T cell acute lymphoblastic leukemia.
Jost TR, Borga C, Radaelli E, Romagnani A, Perruzza L, Omodho L, Cazzaniga G, Biondi A, Indraccolo S, Thelen M, Te Kronnie G, Grassi F.
J Leukoc Biol (2016) 99:1077-87

Platelet-derived growth factor-alpha receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer.
Kabanova A, Marcandalli J, Zhou T, Bianchi S, Baxa U, Tsybovsky Y, Lilleri D, Silacci-Fregni C, Foglierini M, Fernandez-Rodriguez BM, Druz A, Zhang B, Geiger R, Pagani M, Sallusto F, Kwong PD, Corti D, Lanzavecchia A, Perez L.
Nat Microbiol (2016) 1:16082

Normalization of circulating microRNA expression data obtained by quantitative real-time RT-PCR.
Marabita F, de Candia P, Torri A, Tegner J, Abrignani S, Rossi RL.
Brief Bioinform (2016) 17:204-12

The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling.
Marfia G, Navone SE, Hadi LA, Paroni M, Berno V, Beretta M, Gualtierotti R, Ingegnoli F, Levi V, Miozzo M, Geginat J, Fassina L, Rampini P, Tremolada C, Riboni L, Campanella R.
Stem Cells Dev (2016) 25:1095-107

Nucleoplasmic Lamin A/C and Polycomb group of proteins: An evolutionarily conserved interplay.
Marullo F, Cesarini E, Antonelli L, Gregoretti F, Oliva G, Lanzuolo C.
Nucleus (2016) 7:103-11

Translational control by mTOR-independent routes: how eIF6 organizes metabolism.
Miluzio A, Ricciardi S, Manfrini N, Alfieri R, Oliveto S, Brina D, Biffo S.
Biochem Soc Trans (2016) 44:1667-1673

CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization.
Nawaz MS, Giarda E, Bedogni F, La Montanara P, Ricciardi S, Ciceri D, Alberio T, Landsberger N, Rusconi L, Kilstrup-Nielsen C.
PLoS One (2016) 11:e0148634

IL-10 promotes homeostatic proliferation of human CD8(+) memory T cells and, when produced by CD1c(+) DCs, shapes naive CD8(+) T-cell priming.
Nizzoli G, Larghi P, Paroni M, Crosti MC, Moro M, Neddermann P, Caprioli F, Pagani M, De Francesco R, Abrignani S, Geginat J.
Eur J Immunol (2016) 46:1622-32

Uncontrolled IL-17 Production by Intraepithelial Lymphocytes in a Case of non-IPEX Autoimmune Enteropathy.
Paroni M, Magarotto A, Tartari S, Nizzoli G, Larghi P, Ercoli G, Gianelli U, Pagani M, Elli L, Abrignani S, Conte D, Geginat J, Caprioli F.
Clin Transl Gastroenterol (2016) 7:e182

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.
Pema M, Drusian L, Chiaravalli M, Castelli M, Yao Q, Ricciardi S, Somlo S, Qian F, Biffo S, Boletta A.
Nat Commun (2016) 7:10786

Dopamine receptor type 2 (DRD2) inhibits migration and invasion of human tumorous pituitary cells through ROCK-mediated cofilin inactivation.
Peverelli E, Giardino E, Treppiedi D, Locatelli M, Vaira V, Ferrero S, Bosari S, Lania AG, Spada A, Mantovani G.
Cancer Lett (2016) 381:279-86

Role of Strain Rate in the Pathogenesis of Ventilator-Induced Lung Edema.
Protti A, Maraffi T, Milesi M, Votta E, Santini A, Pugni P, Andreis DT, Nicosia F, Zannin E, Gatti S, Vaira V, Ferrero S, Gattinoni L
Crit Care Med (2016) 44:e838-45

Protein O-mannosylation is crucial for human mesencyhmal stem cells fate.
Ragni E, Lommel M, Moro M, Crosti M, Lavazza C, Parazzi V, Saredi S, Strahl S, Lazzari L.
Cell Mol Life Sci (2016) 73:445-58

Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects.
Rigoni R, Fontana E, Guglielmetti S, Fosso B, D’Erchia AM, Maina V, Taverniti V, Castiello MC, Mantero S, Pacchiana G, Musio S, Pedotti R, Selmi C, Mora JR, Pesole G, Vezzoni P, Poliani PL, Grassi F, Villa A, Cassani B.
J Exp Med (2016) 213:355-75

RAGs and BUGS: An alliance for autoimmunity.
Rigoni R, Grassi F, Villa A, Cassani B.
Gut Microbes (2016) 7:503-511

 

 

 

 

 

Daclatasvir: a team player rather than a prima donna in the treatment of hepatitis C.
Aghemo A, De Francesco R.
Gut (2015) 64:860-2

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.
Arner E, Daub CO, Vitting-Seerup K, Andersson R, Lilje B, Drablos F, Lennartsson A, Ronnerblad M, Hrydziuszko O, Vitezic M, Freeman TC, Alhendi AM, Arner P, Axton R, Baillie JK, Beckhouse A, Bodega B, Briggs J, Brombacher F, Davis M, Detmar M, Ehrlund A, Endoh M, Eslami A, Fagiolini M, Fairbairn L, Faulkner GJ, Ferrai C, Fisher ME, Forrester L, Goldowitz D, Guler R, Ha T, Hara M, Herlyn M, Ikawa T, Kai C, Kawamoto H, Khachigian LM, Klinken SP, Kojima S, Koseki H, Klein S, Mejhert N, Miyaguchi K, Mizuno Y, Morimoto M, Morris KJ, Mummery C, Nakachi Y, Ogishima S, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov D, Passier R, Patrikakis M, Pombo A, Qin XY, Roy S, Sato H, Savvi S, Saxena A, Schwegmann A, Sugiyama D, Swoboda R, Tanaka H, Tomoiu A, Winteringham LN, Wolvetang E, Yanagi-Mizuochi C, Yoneda M, Zabierowski S, Zhang P, Abugessaisa I, Bertin N, Diehl AD, Fukuda S, Furuno M, Harshbarger J, Hasegawa A, Hori F, Ishikawa-Kato S, Ishizu Y, Itoh M, Kawashima T, Kojima M, Kondo N, Lizio M, Meehan TF, Mungall CJ, Murata M, Nishiyori-Sueki H, Sahin S, Nagao-Sato S, Severin J, de Hoon MJ, Kawai J, Kasukawa T, Lassmann T, Suzuki H, Kawaji H, Summers KM, Wells C, Consortium F, Hume DA, Forrest AR, Sandelin A, Carninci P, Hayashizaki Y.
Science (2015) 347:1010-4

Dissection of the cord blood stromal component reveals predictive parameters for culture outcome.
Barilani M, Lavazza C, Vigano M, Montemurro T, Boldrin V, Parazzi V, Montelatici E, Crosti M, Moro M, Giordano R, Lazzari L.
Stem Cells Dev (2015) 24:104-14

G-Force PD: a global initiative in coordinating stem cell-based dopamine treatments for Parkinson’s disease.
Barker RA, Studer L, Cattaneo E, Takahashi J, consortium GFP.
NPJ Parkinsons Dis (2015) 1:15017

De novo transcriptome profiling of highly purified human lymphocytes primary cells.
Bonnal RJ, Ranzani V, Arrigoni A, Curti S, Panzeri I, Gruarin P, Abrignani S, Rossetti G, Pagani M.
Sci Data (2015) 2:150051

miRiadne: a web tool for consistent integration of miRNA nomenclature.
Bonnal RJ, Rossi RL, Carpi D, Ranzani V, Abrignani S, Pagani M.
Nucleic Acids Res (2015) 43:W487-92

eIF6 anti-association activity is required for ribosome biogenesis, translational control and tumor progression.
Brina D, Miluzio A, Ricciardi S, Biffo S.
Biochim Biophys Acta (2015) 1849:830-5

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.
Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen PK, Viero G, Tebaldi T, Offenhauser N, Rozman J, Rathkolb B, Neschen S, Klingenspor M, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Quattrone A, Falciani F, Biffo S.
Nat Commun (2015) 6:8261

Gaps in knowledge and prospects for research of adjuvanted vaccines.
Seder R, Reed SG, O’Hagan D, Malyala P, D’Oro U, Laera D, Abrignani S, Cerundolo V, Steinman L, Bertholet S
Vaccine (2015) 33 Suppl 2:B40-3

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.
Caino MC, Ghosh JC, Chae YC, Vaira V, Rivadeneira DB, Faversani A, Rampini P, Kossenkov AV, Aird KM, Zhang R, Webster MR, Weeraratna AT, Bosari S, Languino LR, Altieri DC.
Proc Natl Acad Sci U S A (2015) 112:8638-43

Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes.
Cesarini E, Mozzetta C, Marullo F, Gregoretti F, Gargiulo A, Columbaro M, Cortesi A, Antonelli L, Di Pelino S, Squarzoni S, Palacios D, Zippo A, Bodega B, Oliva G, Lanzuolo C.
J Cell Biol (2015) 211:533-51

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.
Cheroni C, Donnici L, Aghemo A, Balistreri F, Bianco A, Zanoni V, Pagani M, Soffredini R, D’Ambrosio R, Rumi MG, Colombo M, Abrignani S, Neddermann P, De Francesco R.
PLoS One (2015) 10:e0138546

Systematic comparison of single-chain Fv antibody-fusion toxin constructs containing Pseudomonas Exotoxin A or saporin produced in different microbial expression systems.
Della Cristina P, Castagna M, Lombardi A, Barison E, Tagliabue G, Ceriotti A, Koutris I, Di Leandro L, Giansanti F, Vago R, Ippoliti R, Flavell SU, Flavell DJ, Colombatti M, Fabbrini MS.
Microb Cell Fact (2015) 14:19

The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.
Di Cristofori A, Ferrero S, Bertolini I, Gaudioso G, Russo MV, Berno V, Vanini M, Locatelli M, Zavanone M, Rampini P, Vaccari T, Caroli M, Vaira V.
Oncotarget (2015) 6:17514-31

The calcineurin-NFAT pathway controls activity-dependent circadian gene expression in slow skeletal muscle.
Dyar KA, Ciciliot S, Tagliazucchi GM, Pallafacchina G, Tothova J, Argentini C, Agatea L, Abraham R, Ahdesmaki M, Forcato M, Bicciato S, Schiaffino S, Blaauw B.
Mol Metab (2015) 4:823-33

Deregulation of MiR-34b/Sox2 Predicts Prostate Cancer Progression.
Forno I, Ferrero S, Russo MV, Gazzano G, Giangiobbe S, Montanari E, Del Nero A, Rocco B, Albo G, Languino LR, Altieri DC, Vaira V, Bosari S.
PLoS One (2015) 10:e0130060

The Contrasting Role of p16Ink4A Patterns of Expression in Neuroendocrine and Non-Neuroendocrine Lung Tumors: A Comprehensive Analysis with Clinicopathologic and Molecular Correlations.
Fusco N, Guerini-Rocco E, Del Gobbo A, Franco R, Zito-Marino F, Vaira V, Bulfamante G, Ercoli G, Nosotti M, Palleschi A, Bosari S, Ferrero S.
PLoS One (2015) 10:e0144923

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
Gagliani N, Amezcua Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limon P, Paiva RS, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire LX, Cotton MJ, Drier Y, Bernstein B, Geginat J, Stockinger B, Esplugues E, Huber S, Flavell RA.
Nature (2015) 523:221-5

Working hard at the nexus between cell signaling and the ribosomal machinery: An insight into the roles of RACK1 in translational regulation.
Gallo S, Manfrini N.
Translation (Austin) (2015) 3:e1120382

Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets.
Geginat J, Nizzoli G, Paroni M, Maglie S, Larghi P, Pascolo S, Abrignani S.
Front Immunol (2015) 6:527

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.
Ghosh JC, Siegelin MD, Vaira V, Faversani A, Tavecchio M, Chae YC, Lisanti S, Rampini P, Giroda M, Caino MC, Seo JH, Kossenkov AV, Michalek RD, Schultz DC, Bosari S, Languino LR, Altieri DC.
J Natl Cancer Inst (2015) 107

Signal Strength and Metabolic Requirements Control Cytokine-Induced Th17 Differentiation of Uncommitted Human T Cells.
Kastirr I, Crosti M, Maglie S, Paroni M, Steckel B, Moro M, Pagani M, Abrignani S, Geginat J.
J Immunol (2015) 195:3617-27

Two of Them Do It Better: Novel Serum Biomarkers Improve Autoimmune Hepatitis Diagnosis.
Mazzara S, Sinisi A, Cardaci A, Rossi RL, Muratori L, Abrignani S, Bombaci M.
PLoS One (2015) 10:e0137927

Transmembrane 6 superfamily member 2 gene E167K variant impacts on steatosis and liver damage in chronic hepatitis C patients.
Milano M, Aghemo A, Mancina RM, Fischer J, Dongiovanni P, De Nicola S, Fracanzani AL, D’Ambrosio R, Maggioni M, De Francesco R, Fargion S, Berg T, Stickel F, Hampe J, Romeo S, Colombo M, Valenti L.
Hepatology (2015) 62:111-7

Expression and activity of eIF6 trigger malignant pleural mesothelioma growth in vivo.
Miluzio A, Oliveto S, Pesce E, Mutti L, Murer B, Grosso S, Ricciardi S, Brina D, Biffo S.
Oncotarget (2015) 6:37471-85

Epigenetic alterations in cancer and personalized cancer treatment.
Miozzo M, Vaira V, Sirchia SM.
Future Oncol (2015) 11:333-48

Reference proteome of highly purified human Th1 cells reveals strong effects on metabolism and protein ubiquitination upon differentiation.
Pagani M, Rockstroh M, Schuster M, Rossetti G, Moro M, Crosti M, Tomm JM.
Proteomics (2015) 15:3644-7

Long Intergenic Non-Coding RNAs: Novel Drivers of Human Lymphocyte Differentiation.
Panzeri I, Rossetti G, Abrignani S, Pagani M.
Front Immunol (2015) 6:175

Direct and high throughput (HT) interactions on the ribosomal surface by iRIA.
Pesce E, Minici C, Babetaler J, Hurt E, Degano M, Calamita P, Biffo S.
Sci Rep (2015) 5:15401

The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.
Ranzani V, Rossetti G, Panzeri I, Arrigoni A, Bonnal RJ, Curti S, Gruarin P, Provasi E, Sugliano E, Marconi M, De Francesco R, Geginat J, Bodega B, Abrignani S, Pagani M.
Nat Immunol (2015) 16:318-325

Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation.
Ricciardi S, Miluzio A, Brina D, Clarke K, Bonomo M, Aiolfi R, Guidotti LG, Falciani F, Biffo S.
J Thromb Haemost (2015) 13:2108-18

A new mouse avatar model of non-small cell lung cancer.
Russo MV, Faversani A, Gatti S, Ricca D, Del Gobbo A, Ferrero S, Palleschi A, Vaira V, Bosari S.
Front Oncol (2015) 5:52

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth.
Zanconato F, Forcato M, Battilana G, Azzolin L, Quaranta E, Bodega B, Rosato A, Bicciato S, Cordenonsi M, Piccolo S.
Nat Cell Biol (2015) 17:1218-27

Enhancement of Muscle T Regulatory Cells and Improvement of Muscular Dystrophic Process in mdx Mice by Blockade of Extracellular ATP/P2X Axis.
Gazzerro E, Baldassari S, Assereto S, Fruscione F, Pistorio A, Panicucci C, Volpi S, Perruzza L, Fiorillo C, Minetti C, Traggiai E, Grassi F, Bruno C.
Am J Pathol. (2015); 185(12):3349-60.

 

 

 

 

 

Absence of a role for interleukin-13 in inflammatory bowel disease.
Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque SS, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza GR, MacDonald TT.
Eur J Immunol (2014) 44:370-85

Repetitive elements dynamics in cell identity programming, maintenance and disease.
Bodega B, Orlando V.
Curr Opin Cell Biol (2014) 31:67-73

Third trimester NG2-positive amniotic fluid cells are effective in improving repair in spinal cord injury.
Bottai D, Scesa G, Cigognini D, Adami R, Nicora E, Abrignani S, Di Giulio AM, Gorio A.
Exp Neurol (2014) 254:121-33

The association of IL28B genotype with the histological features of chronic hepatitis C is HCV genotype dependent.
D’Ambrosio R, Aghemo A, De Francesco R, Rumi MG, Galmozzi E, De Nicola S, Cheroni C, Clark PJ, Ronchi G, Lampertico P, Colombo M.
Int J Mol Sci (2014) 15:7213-24

Serum microRNAs as Biomarkers of Human Lymphocyte Activation in Health and Disease.
de Candia P, Torri A, Pagani M, Abrignani S.
Front Immunol (2014) 5:43

Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C.
De Nicola S, Dongiovanni P, Aghemo A, Cheroni C, D’Ambrosio R, Pedrazzini M, Marabita F, Donnici L, Maggioni M, Fargion S, Colombo M, De Francesco R, Valenti L.
PLoS One (2014) 9:e106022

Interleukin 28B genotype and insulin resistance in chronic hepatitis C patients.
Degasperi E, Valenti L, Aghemo A, De Francesco R, Rumi M, Soffredini R, Donnici L, Cheroni C, Fargion S, Zanoni V, Orsi E, Colombo M.
Antivir Ther (2014) 19:747-53

iNKT-cell help to B cells: a cooperative job between innate and adaptive immune responses.
Dellabona P, Abrignani S, Casorati G.
Eur J Immunol (2014) 44:2230-7

In vitro antibiofilm activity of bioactive glass S53P4.
Drago L, Vassena C, Fenu S, De Vecchi E, Signori V, De Francesco R, Romano CL.
Future Microbiol (2014) 9:593-601

Plasticity of human CD4 T cell subsets.
Geginat J, Paroni M, Maglie S, Alfen JS, Kastirr I, Gruarin P, De Simone M, Pagani M, Abrignani S.
Front Immunol (2014) 5:630

A proteomic approach to investigate AuNPs effects in Balb/3T3 cells.
Gioria S, Chassaigne H, Carpi D, Parracino A, Meschini S, Barboro P, Rossi F.
Toxicol Lett (2014) 228:111-26

IL-21 is a central memory T cell-associated cytokine that inhibits the generation of pathogenic Th1/17 effector cells.
Kastirr I, Maglie S, Paroni M, Alfen JS, Nizzoli G, Sugliano E, Crosti MC, Moro M, Steckel B, Steinfelder S, Stolzel K, Romagnani C, Botti F, Caprioli F, Pagani M, Abrignani S, Geginat J.
J Immunol (2014) 193:3322-31

Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.
McGivern DR, Masaki T, Williford S, Ingravallo P, Feng Z, Lahser F, Asante-Appiah E, Neddermann P, De Francesco R, Howe AY, Lemon SM.
Gastroenterology (2014) 147:453-62 e7

The characterization of a novel monoclonal antibody against CD93 unveils a new antiangiogenic target.
Orlandini M, Galvagni F, Bardelli M, Rocchigiani M, Lentucci C, Anselmi F, Zippo A, Bini L, Oliviero S.
Oncotarget (2014) 5:2750-60

Diet composition transiently modulates proliferative and potency features of human cord blood-derived mesenchymal stem cells.
Ragni E, Parazzi V, Crosti M, Moro M, Giordano R, Lazzari L.
Int J Biochem Cell Biol (2014) 55:269-78

NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIalpha complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes.
Reghellin V, Donnici L, Fenu S, Berno V, Calabrese V, Pagani M, Abrignani S, Peri F, De Francesco R, Neddermann P.
Antimicrob Agents Chemother (2014) 58:7128-40

Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis.
Selmi C, Cavaciocchi F, Lleo A, Cheroni C, De Francesco R, Lombardi SA, De Santis M, Meda F, Raimondo MG, Crotti C, Folci M, Zammataro L, Mayo MJ, Bach N, Shimoda S, Gordon SC, Miozzo M, Invernizzi P, Podda M, Scavelli R, Martin MR, Seldin MF, Lasalle JM, Gershwin ME.
Front Immunol (2014) 5:128

Photodynamic antibacterial and antibiofilm activity of RLP068/Cl against Staphylococcus aureus and Pseudomonas aeruginosa forming biofilms on prosthetic material.
Vassena C, Fenu S, Giuliani F, Fantetti L, Roncucci G, Simonutti G, Romano CL, De Francesco R, Drago L.
Int J Antimicrob Agents (2014) 44:47-55

Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.
Wang H, Perry JW, Lauring AS, Neddermann P, De Francesco R, Tai AW.
Gastroenterology (2014) 146:1373-85 e1-11

Why is it so difficult to develop a hepatitis C virus preventive vaccine?
Zingaretti C, De Francesco R, Abrignani S.
Clin Microbiol Infect (2014) 20 Suppl 5:103-9

 

 

 

 

 

 

New horizons in hepatitis C antiviral therapy with direct-acting antivirals.
Aghemo A, De Francesco R.
Hepatology (2013) 58:428-38

Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients.
Aghemo A, Degasperi E, Rumi MG, Galmozzi E, Valenti L, De Francesco R, De Nicola S, Cheroni C, Grassi E, Colombo M.
Biomed Res Int (2013) 2013:580796

 

Reduction of CD68+ macrophages and decreased IL-17 expression in intestinal mucosa of patients with inflammatory bowel disease strongly correlate with endoscopic response and mucosal healing following infliximab therapy.
Caprioli F, Bose F, Rossi RL, Petti L, Vigano C, Ciafardini C, Raeli L, Basilisco G, Ferrero S, Pagani M, Conte D, Altomare G, Monteleone G, Abrignani S, Reali E.
Inflamm Bowel Dis (2013) 19:729-39

 

Intracellular modulation, extracellular disposal and serum increase of MiR-150 mark lymphocyte activation.
de Candia P, Torri A, Gorletta T, Fedeli M, Bulgheroni E, Cheroni C, Marabita F, Crosti M, Moro M, Pariani E, Romano L, Esposito S, Mosca F, Rossetti G, Rossi RL, Geginat J, Casorati G, Dellabona P, Pagani M, Abrignani S.
PLoS One (2013) 8:e75348

 

Hepatitis C virus-specific directly acting antiviral drugs.
Delang L, Neyts J, Vliegen I, Abrignani S, Neddermann P, De Francesco R.
Curr Top Microbiol Immunol (2013) 369:289-320

 

The CD4-centered universe of human T cell subsets.
Geginat J, Paroni M, Facciotti F, Gruarin P, Kastirr I, Caprioli F, Pagani M, Abrignani S.
Semin Immunol (2013) 25:252-62

 

IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B.
Lampertico P, Vigano M, Cheroni C, Facchetti F, Invernizzi F, Valveri V, Soffredini R, Abrignani S, De Francesco R, Colombo M.
Hepatology (2013) 57:890-6

 

A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans.
Law JL, Chen C, Wong J, Hockman D, Santer DM, Frey SE, Belshe RB, Wakita T, Bukh J, Jones CT, Rice CM, Abrignani S, Tyrrell DL, Houghton M.
PLoS One (2013) 8:e59776

 

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.
Nizzoli G, Krietsch J, Weick A, Steinfelder S, Facciotti F, Gruarin P, Bianco A, Steckel B, Moro M, Crosti M, Romagnani C, Stolzel K, Torretta S, Pignataro L, Scheibenbogen C, Neddermann P, De Francesco R, Abrignani S, Geginat J.
Blood (2013) 122:932-42

 

Role of microRNAs and long-non-coding RNAs in CD4(+) T-cell differentiation.
Pagani M, Rossetti G, Panzeri I, de Candia P, Bonnal RJ, Rossi RL, Geginat J, Abrignani S.
Immunol Rev (2013) 253:82-96

 

 

 

 

 

 

 

 

Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case.
Bensi G, Mora M, Tuscano G, Biagini M, Chiarot E, Bombaci M, Capo S, Falugi F, Manetti AG, Donato P, Swennen E, Gallotta M, Garibaldi M, Pinto V, Chiappini N, Musser JM, Janulczyk R, Mariani M, Scarselli M, Telford JL, Grifantini R, Norais N, Margarit I, Grandi G.
Mol Cell Proteomics (2012) 11:M111 015693

 

Metabolism of phosphatidylinositol 4-kinase IIIalpha-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity.
Bianco A, Reghellin V, Donnici L, Fenu S, Alvarez R, Baruffa C, Peri F, Pagani M, Abrignani S, Neddermann P, De Francesco R.
PLoS Pathog (2012) 8:e1002576

 

Biogem: an effective tool-based approach for scaling up open source software development in bioinformatics.
Bonnal RJ, Aerts J, Githinji G, Goto N, MacLean D, Miller CA, Mishima H, Pagani M, Ramirez-Gonzalez R, Smant G, Strozzi F, Syme R, Vos R, Wennblom TJ, Woodcroft BJ, Katayama T, Prins P.
Bioinformatics (2012) 28:1035-7

 

Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4.
De Nicola S, Aghemo A, Rumi MG, Galmozzi E, Valenti L, Soffredini R, De Francesco R, Prati GM, D’Ambrosio R, Cheroni C, Donato MF, Colombo M.
Hepatology (2012) 55:336-42

 

Surface interactome in Streptococcus pyogenes.
Galeotti CL, Bove E, Pezzicoli A, Nogarotto R, Norais N, Pileri S, Lelli B, Falugi F, Balloni S, Tedde V, Chiarot E, Bombaci M, Soriani M, Bracci L, Grandi G, Grifantini R.
Mol Cell Proteomics (2012) 11:M111 015206

 

Identification of new hematopoietic cell subsets with a polyclonal antibody library specific for neglected proteins.
Moro M, Crosti M, Creo P, Gallina P, Curti S, Sugliano E, Scavelli R, Cattaneo D, Canidio E, Marconi M, Rebulla P, Sarmientos P, Viale G, Pagani M, Abrignani S.
PLoS One (2012) 7:e34395

 

Circulating hepatitis B surface antigen particles carry hepatocellular microRNAs.
Novellino L, Rossi RL, Bonino F, Cavallone D, Abrignani S, Pagani M, Brunetto MR.
PLoS One (2012) 7:e31952

 

Development of an influenza virus protein array using Sortagging technology.
Sinisi A, Popp MW, Antos JM, Pansegrau W, Savino S, Nissum M, Rappuoli R, Ploegh HL, Buti L.
Bioconjug Chem (2012) 23:1119-26

 

Follicular helper NKT cells induce limited B cell responses and germinal center formation in the absence of CD4(+) T cell help.
Tonti E, Fedeli M, Napolitano A, Iannacone M, von Andrian UH, Guidotti LG, Abrignani S, Casorati G, Dellabona P.
J Immunol (2012) 188:3217-22

 

Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis.
Zingaretti C, Arigo M, Cardaci A, Moro M, Crosti M, Sinisi A, Sugliano E, Cheroni C, Marabita F, Nogarotto R, Bonnal RJ, Marcatili P, Marconi M, Zignego A, Muratori P, Invernizzi P, Colombatto P, Brunetto M, Bonino F, De Francesco R, Geginat J, Pagani M, Muratori L, Abrignani S, Bombaci M.
Mol Cell Proteomics (2012) 11:1885-97

 

 

 

 

 

 

 

 

Dual role of anti-TNF therapy: enhancement of TCR-mediated T cell activation in peripheral blood and inhibition of inflammation in target tissues.
Bose F, Raeli L, Garutti C, Frigerio E, Cozzi A, Crimi M, Caprioli F, Scavelli R, Altomare G, Geginat J, Abrignani S, Reali E.
Clin Immunol (2011) 139:164-76

 

Substantial histone reduction modulates genomewide nucleosomal occupancy and global transcriptional output.
Celona B, Weiner A, Di Felice F, Mancuso FM, Cesarini E, Rossi RL, Gregory L, Baban D, Rossetti G, Grianti P, Pagani M, Bonaldi T, Ragoussis J, Friedman N, Camilloni G, Bianchi ME, Agresti A.
PLoS Biol (2011) 9:e1001086

 

Nutritional limitation sensitizes mammalian cells to GSK-3beta inhibitors and leads to growth impairment.
de Candia P, Minopoli G, Verga V, Gargiulo A, Vanoni M, Alberghina L.
Am J Pathol (2011) 178:1814-23

 

A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dolle P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A.
PLoS Biol (2011) 9:e1000582

 

A novel polyclonal antibody library for expression profiling of poorly characterized, membrane and secreted human proteins.
Grifantini R, Pagani M, Pierleoni A, Grandi A, Parri M, Campagnoli S, Pileri P, Cattaneo D, Canidio E, Pontillo A, De Camilli E, Bresciani A, Marinoni F, Pedrazzoli E, Nogarotto R, Abrignani S, Viale G, Sarmientos P, Grandi G.
J Proteomics (2011) 75:532-47

 

Genetic variation in the interleukin-28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection.
Marabita F, Aghemo A, De Nicola S, Rumi MG, Cheroni C, Scavelli R, Crimi M, Soffredini R, Abrignani S, De Francesco R, Colombo M.
Hepatology (2011) 54:1127-34

 

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase.
Narjes F, Crescenzi B, Ferrara M, Habermann J, Colarusso S, Ferreira Mdel R, Stansfield I, Mackay AC, Conte I, Ercolani C, Zaramella S, Palumbi MC, Meuleman P, Leroux-Roels G, Giuliano C, Fiore F, Di Marco S, Baiocco P, Koch U, Migliaccio G, Altamura S, Laufer R, De Francesco R, Rowley M.
J Med Chem (2011) 54:289-301

 

Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b.
Rossi RL, Rossetti G, Wenandy L, Curti S, Ripamonti A, Bonnal RJ, Birolo RS, Moro M, Crosti MC, Gruarin P, Maglie S, Marabita F, Mascheroni D, Parente V, Comelli M, Trabucchi E, De Francesco R, Geginat J, Abrignani S, Pagani M.
Nat Immunol (2011) 12:796-803

 

Immunization of human volunteers with hepatitis C virus envelope glycoproteins elicits antibodies that cross-neutralize heterologous virus strains.
Stamataki Z, Coates S, Abrignani S, Houghton M, McKeating JA.
J Infect Dis (2011) 204:811-3

 

Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells.
Steinfelder S, Floess S, Engelbert D, Haeringer B, Baron U, Rivino L, Steckel B, Gruetzkau A, Olek S, Geginat J, Huehn J, Hamann A.
Blood (2011) 117:2839-46

 

 

 

 

 

 

 

Reliable resequencing of the human dystrophin locus by universal long polymerase chain reaction and massive pyrosequencing.
Bonnal RJ, Severgnini M, Castaldi A, Bordoni R, Iacono M, Trimarco A, Torella A, Piluso G, Aurino S, Condorelli G, De Bellis G, Nigro V.
Anal Biochem (2010) 406:176-84

 

Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults.
Frey SE, Houghton M, Coates S, Abrignani S, Chien D, Rosa D, Pileri P, Ray R, Di Bisceglie AM, Rinella P, Hill H, Wolff MC, Schultze V, Han JH, Scharschmidt B, Belshe RB.
Vaccine (2010) 28:6367-73

 

BioRuby: bioinformatics software for the Ruby programming language.
Goto N, Prins P, Nakao M, Bonnal R, Aerts J, Katayama T.
Bioinformatics (2010) 26:2617-9

 

RSSsite: a reference database and prediction tool for the identification of cryptic Recombination Signal Sequences in human and murine genomes.
Merelli I, Guffanti A, Fabbri M, Cocito A, Furia L, Grazini U, Bonnal RJ, Milanesi L, McBlane F.
Nucleic Acids Res (2010) 38:W262-7

 

Characterization of nucleotide misincorporation patterns in the iceman’s mitochondrial DNA.
Olivieri C, Ermini L, Rizzi E, Corti G, Bonnal R, Luciani S, Marota I, De Bellis G, Rollo F.
PLoS One (2010) 5:e8629

 

Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines.
Powdrill MH, Deval J, Narjes F, De Francesco R, Gotte M.
Antimicrob Agents Chemother (2010) 54:977-83

 

Characterization of antibodies induced by vaccination with hepatitis C virus envelope glycoproteins.
Ray R, Meyer K, Banerjee A, Basu A, Coates S, Abrignani S, Houghton M, Frey SE, Belshe RB.
J Infect Dis (2010) 202:862-6

 

CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function.
Rivino L, Gruarin P, Haringer B, Steinfelder S, Lozza L, Steckel B, Weick A, Sugliano E, Jarrossay D, Kuhl AA, Loddenkemper C, Abrignani S, Sallusto F, Lanzavecchia A, Geginat J.
J Exp Med (2010) 207:565-77

 

Biology of interleukin-10.
Sabat R, Grutz G, Warszawska K, Kirsch S, Witte E, Wolk K, Geginat J.
Cytokine Growth Factor Rev (2010) 21:331-44

 

Streptococcus pyogenes SpyCEP: a chemokine-inactivating protease with unique structural and biochemical features.
Zingaretti C, Falugi F, Nardi-Dei V, Pietrocola G, Mariani M, Liberatori S, Gallotta M, Tontini M, Tani C, Speziale P, Grandi G, Margarit I.
FASEB J (2010) 24:2839-48

 

 

 

 

 

B cell helper assays.
Abrignani S, Tonti E, Casorati G, Dellabona P.
Methods Mol Biol (2009) 514:15-26

The mitochondrial genome, a growing interest inside an organelle.
Crimi M, Rigolio R.
Int J Nanomedicine (2008) 3:51-7