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Nicola Manfrini received his Master’s degree in Industrial Biotechnologies at the University of Milano-Bicocca in 2007 and obtained a Ph.D. in Biology at the same University in 2011. During his doctoral studies and throughout his first post-doc in the lab of Professor Maria Pia Longhese, he focused on characterizing the DNA damage checkpoint, using S. cerevisiae as a model system. In this period he won a three-year AIRC fellowship and collaborated, as visiting scientist, with Professor Antonin Morillon at the Curie Institute in Paris, France.
For his second postdoc, in 2015 he moved to the lab of Professor Stefano Biffo at the INGM Institute, shifting towards a more applied type of research, finalised at defining: 1) how translation regulates cell metabolism, in both physiological and pathological contexts and 2) novel altered pathways in cancer, focusing primarily on characterizing the role of the new tumour suppressor FAM46C.
He is Assistant Professor at the University of Milan since 2021 and in 2022 he started his independent career at the INGM Institute after winning the MFAG grant from AIRC.
Currently, his line of research is focused on identifying, characterising and evaluating the targetability of new cancer-associated genes and pathways, giving special attention to the ones modulated by the oncosuppressor complex FAM46C/FNDC3A.

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