• GRUPPI DI RICERCA
  • Abrignani Lab
  • – Albanese Lab
  • Biffo Lab
  • – Manfrini Lab
  • Bodega Lab
  • – Marasca Lab
  • Cattaneo Lab
  • De Francesco Lab
  • Geginat Lab
  • Grassi Lab
  • Grifantini Lab
  • Lanzavecchia Lab
  • Lanzuolo Lab
  • Manganaro Lab
  • Montini Lab
  • Rizzello Lab
• PIATTAFORME
  • Bioinformatica
  • Citofluorimetria
  • Microscopia
  • Centro Organoidi
• PUBBLICAZIONI
  • Anno corrente
  • Archivio

• Decoration of gold nanoparticles with glycopeptides leads to a lower cellular uptake and liver retention.
  Soliman MG, Alarcon JF, Lüdtke TU, Violatto MB, Dobricic M, Cordiglieri C, Corbelli A, Fiordaliso F, Sitia G, O’Donnell JS, Spencer DIR, Moya S, Bigini P, Monopoli MP.
  Nanoscale Adv. 2025 Aug 12.
• Coupling mechanisms coordinating mRNA translation with stages of the mRNA lifecycle.
  Famà V, Coscujuela Tarrero L, Albanese R, Calviello L, Biffo S, Pelizzola M, Furlan M.
  RNA Biol. 2025 Dec;22(1):1-12.
• Lamin A/C regulates cerebellar granule cell maturation.
  Vilardo L, Cifola I, Nardella M, Pelucchi P, Ciotti MT, Bianchi A, Rinaldi A, Arisi I, Brandi R, d’Onofrio M, Galvanetto N, Gatti G, Catalano M, Lanzuolo C, Guglielmi L, D’Agnano I.
  Cell Biol Toxicol. 2025 Apr 5;41(1):66.
• The power of microRNA regulation-insights into immunity and metabolism.
  Oliveto S, Manfrini N, Biffo S.
  FEBS Lett. 2025 Jul;599(13):1821-1851.
• Nucleotide composition shapes gene expression in Wolbachia pipientis: a role for MidA methyltransferase?
  Papaleo S, Panelli S, Bitar I, Sterzi L, Nodari R, Comandatore F.
  mSystems. 2025 Aug 15:e0077925.
• Recent developments in managing luminal microbial ecology in patients with inflammatory bowel disease: from evidence to microbiome-based diagnostic and personalized therapy.
  Bonazzi E, De Barba C, Lorenzon G, Maniero D, Bertin L, Barberio B, Facciotti F, Caprioli F, Scaldaferri F, Zingone F, Savarino EV.
  Expert Rev Gastroenterol Hepatol. 2025 Apr-May;19(5):563-576.
• Nanotechnology in brain cancer treatment: The role of gold nanoparticles as therapeutic enhancers.
  Tarantino S, Bianco A, De Matteis V, Scarpa E, Rinaldi R.
  Ibrain. 2025 May 10;11(2):119-145.
• Six-month follow-up of antibody response to bivalent mRNA SARS-CoV-2 vaccine booster in healthcare workers.
  Fedele G, Schiavoni I, Trentini F, Leone P, Olivetta E, Fiore S, Di Martino A, Abrignani S, Bandera A, Clerici P, De Paschale M, Fallucca A, Fortunato F, Gori A, Grifantini R, Lazzarotto T, Lodi V, Orsi A, Prato R, Restivo V, Ricucci V, Palamara AT, Stefanelli P; COVAC-2 Study Group.
  Vaccine. 2025 Jul 30:62:127524.
• Exploring Human Use of Monoclonal Antibodies Against Critical Bacteria: A Scoping Review of Clinical Trials.
  Piscaglia M, Scaglione G, Genovese C, Borgonovo F, Brivio F, Rampichini F, Grifantini R, Bandera A, Gori A, Colaneri M, Palomba E.
  Infect Dis Ther. 2025 Aug;14(8):1619-1647.
• GMMA decorated with mucin 1 Tn/STn mimetics elicit specific antibodies response and inhibit tumor growth.
  Pesce E, Sodini A, Palmieri E, Valensin S, Tinti C, Rossi M, De Rosa A, Fragai M, Papi F, Cordiglieri C, Berti F, Grifantini R*, Micoli F*, Nativi C*.
  NPJ Vaccines. 2025 Apr 15;10(1):71.
• A rapid and robust luciferase-based reporter system to assess SARS-CoV-2 protease activity.
  Lucini Paioni A, Donnici L, Nodari R, Longo Minnolo M, Ferraro A, Alberico A , Brindisi M, MejíasPérez E, Keppler OT , Summa V , Guidotti LG , Albanese M & De Francesco R
  Virology 2025, doi:10.1016/j.virol.2025.110659
• FAM46C Expression Sensitizes Multiple Myeloma Cells to PF-543-Induced Cytotoxicity.
  Miluzio A, De Grossi F, Mancino M, Biffo S, Manfrini N.
  Biomolecules. 2025 Apr 26;15(5):623.
• Nanoenabling MbtI Inhibitors for Next-Generation Tuberculosis Therapy.
  Cazzaniga G, Mori M, Griego A, Scarpa E, Moschetti G, Muzzioli S, Stelitano G, Chiarelli LR, Cocorullo M, Casali E, Porta A, Zanoni G, Tresoldi A, Pini E, Batalha ÍL, Battaglia G, Tuccinardi T, Rizzello L, Villa S, Meneghetti F.
  J Med Chem. 2025 Mar 13;68(5):5312-5332.
• Biomimetic Recognition of SARS-CoV-2 Receptor-Binding Domain N-Glycans by an Antiviral Synthetic Receptor.
  Santambrogio C, Toccafondi M, Donnici L, Pesce E, De Francesco R, Grifantini R, Ponzini E, Milanesi F, Fragai M, Nativi C, Roelens S, Grandori R, Francesconi O.
  Chembiochem. 2025 Feb 21:e202500106.
• V-ATPase in glioma stem cells: a novel metabolic vulnerability.
  Storaci AM, Bertolini I, Martelli C, De Turris G, Mansour N, Crosti M, De Filippo MR, Ottobrini L, Valenti L, Polledri E, Fustinoni S, Caroli M, Fanizzi C, Bosari S, Ferrero S, Zadra G, Vaira V.
  J Exp Clin Cancer Res. 2025 Jan 17;44(1):17.
• Navigating triplet repeats sequencing: concepts, methodological challenges and perspective for Huntington’s disease.
  Maestri S, Scalzo D, Damaggio G, Zobel M, Besusso D, Cattaneo E.
  Nucleic Acids Res. 2025 Jan 7;53(1):gkae1155.
• When repetita no-longer iuvant: somatic instability of the CAG triplet in Huntington’s disease.
  Cattaneo E, Scalzo D, Zobel M, Iennaco R, Maffezzini C, Besusso D, Maestri S.
  Nucleic Acids Res. 2025 Jan 7;53(1):gkae1204.
• Macrophages producing chondroitin sulfate proteoglycan-4 induce neuro-cardiac junction impairment in Duchenne muscular dystrophy.
  Milan M, Maiullari F, Chirivì M, Ceraolo MG, Zigiotto R, Soluri A, Maiullari S, Landoni E, Silvestre DD, Brambilla F, Mauri P, De Paolis V, Fratini N, Crosti MC, Cordiglieri C, Parisi C, Calogero A, Seliktar D, Torrente Y, Lanzuolo C, Dotti G, Toccafondi M, Bombaci M, De Falco E, Bearzi C, Rizzi R.
  J Pathol. 2025 Jan;265(1):1-13.
• eIF3d specialized translation requires a RACK1-driven eIF3d binding to 43S PIC in proliferating SH-SY5Y neuroblastoma cells.
  Silvestri F, Montuoro R, Catalani E, Tilesi F, Willems D, Romano N, Ricciardi S, Cervia D, Ceci M.
  Cell Signal. 2025 Jan;125:111494.
• Modulation of Autophagy by Oncosuppressor FAM46C and Its Implications for Cancer Therapy: An Intriguing Perspective.
  Manfrini N.
  Biomolecules. 2025 Jan 30;15(2):196.
• Dual Activation-Induced Marker Combinations Efficiently Identify and Discern Antigen-Specific and Bystander-Activated Human CD4+ T Cells.
  Ceraolo MG, Leccese M, Cassotta A, Triolo S, Bombaci M, Coluccio E, Prati D, Ungaro R, Abrignani S, Bandera A, Sallusto F, Lanzavecchia A, Notarbartolo S.
  Eur J Immunol. 2025 Feb;55(2):e202451404.
• Reduced spike specific T-cell responses in COVID-19 vaccinated subjects undergoing SARS-CoV-2 breakthrough infection
  Varchetta S, Golfetto FS, Bono P, Callegaro A, Fabbris T, Favalli A, Crosti M, De Feo TM, Iannotti N, Bozzi G, Castelli V, Mariani B, Muscatello A, Abrignani S, Grifantini R, Bandera A, Lombardi A.
  Front Immunol. 2025 Sep 5;16:1657082
• Impact of chemotherapy on humoral and cellular immune responses to COVID-19 vaccination in patients with solid tumors
  Favalli A, Patelli G, Gruarin P, Gobbini A, Pesce E, Mariano S, Bombaci M, Vincenti F, Donnici L, Marchese S, Piscazzi D, Amatu A, Tosi F, Ghezzi S, Pani A, Principato S, Lombardi A, Bandera A, Abrignani S, Siena S, Sartore-Bianchi A, Grifantini R.
  Front Immunol. 2025 Sep 25;16:1664072.
• The molecular basis of lamin-specific chromatin interactions.
  Wang B, Kronenberg-Tenga R, Rosti V, Di Patrizio Soldateschi E, Luo Q, Iannacchero UM, Pinet L, Eibauer M, Boujemaa-Paterski R, Schuler B, Lanzuolo C, Medalia O.
  Nat Struct Mol Biol. 2025 Oct;32(10):1999-2011.
• Secretory IgA amplification during immune checkpoint blockade enhances the control of tumor growth by enterotropic T cells.
  De Ponte Conti B, Marino R, Rezzonico-Jost T, Forcato M, Mangani D, Notario E, Gargari G, Carelli E, Rinaldi A, Raimondi A, Moro S, Marzano M, Visci G, Perruzza L, Raneri M, Dallavalle D, Mantegazza G, Montani L, Prisco F, Takur R, Geginat J, Seehusen F, Notarbartolo S, Pesole G, Bicciato S, Guglielmetti S, Grassi F.
  Sci Adv. 2025 Oct 3;11(40):eaeb5308.
• The Human Bone Marrow May Offer an IL-15-Dependent Survival Niche for EOMES+ Tr1-Like Cells.
  Pulvirenti N, Vasco C, Righetti C, Dadova P, Boffa G, Laroni A, Vigo T, Raiola AM, Crosti MC, Maglie S, Valenti L, Prati D, Abrigani S, Uccelli A, Geginat J.
  Eur J Immunol. 2025 May;55(5):e202451644.
• Therapeutic potential of targeting the FLNA-regulated Wee1 kinase in adrenocortical carcinomas.
  Esposito E, Marra G, Catalano R, Maioli S, Nozza E, Barbieri AM, Hantel C, Di Dalmazi G, Sigala S, Geginat J, Cassinotti E, Baldari L, Palmieri S, Mangone A, Berruti A, Ferrante E, Mantovani G, Peverelli E.
  Int J Cancer. 2025 Mar 15;156(6):1256-1271.
• Nintedanib for patients with lymphangioleiomyomatosis: a phase 2, open-label, single-arm study.
  Harari S, Elia D, Caminati A, Geginat J, Luisi F, Pelosi G, Specchia C, Torre O, Trevisan R, Vasco C, Zompatori M, Cassandro R.
  Lancet Respir Med. 2024 Dec;12(12):967-974.
• Mechanical Cues Regulate Cargo Sorting and Export at the Golgi.
  Serafino G, Forciniti S, Scarpa E, Ranieri A, Santorelli L, De Blasi G, Costantini S, Lee EJ, Galeone A, Calcagnì A, Pirozzi M, Del Mercato LL, Venditti R, D’Angelo G, Parashuraman S, Verri T, Gigli G, Sztul ES, Grumati P, Rizzello L, Russo D, Rizzo R.
  Adv Sci (Weinh). 2025 Oct 14:e06241.
• Stem Cell Revolutions: An alliance for Parkinson’s disease driven by European Commission consortia.
  Cattaneo E, Besusso D.
  Pharmacol Res. 2025 Feb;212:107569.
• Transplanted human striatal progenitors exhibit functional integration and modulate host circuitry in a Huntington’s disease animal model.
  Scaramuzza L, Ribodino M, Cassarino C, Morrocchi M, Gomez Gonzalez GB, Parolisi R, Sozzi E, Turrini G, Cerrato V, Conforti P, Hoxha E, Tognato R, Galeotti G, Cordiglieri C, Crosti MC, Zucca S, Lorenzati M, Bovetti S, Spaiardi P, de’Sperati C, Biella G, Ottoboni L, Parmar M, Maestri S, Besusso D, Cattaneo E, Buffo A.
  Pharmacol Res. 2025 Sep;219:107905.
• Genetic Deletion of the Purinergic Receptor P2rx7 Worsens the Phenotype of α‑Sarcoglycan Muscular Dystrophy.
  Astigiano C, Principi E, Pintus S, Benzi A, Baratto S, Panicucci C, Passalacqua M, Sierra-Marquez J, Nicke A, Antonini F, Del Zotto G, Cicatiello AG, Raffaghello L, Rezzonico Jost T, Grassi F, Bruzzone S, Bruno C, Gazzerro E.
  ACS Pharmacol Transl Sci. 2025 Sep 11;8(10):3477-3489.
• Abundant Yet Aberrant T Helper Cell Responses to Candida albicans Underlie Mucosal Candidiasis in Humans and Mice.
  Basso C, De Gregorio C, Marzi R, Kirchner F, Gyülveszi G, Migaud M, Paul S, Sette A, Lanzavecchia A, LeibundGut-Landmann S, Casanova JL, Puel A, Becattini S, Sallusto F.
  Eur J Immunol. 2025 Oct;55(10):e70065.
• Clonal analysis of SepSecS-specific B and T cells in autoimmune hepatitis.
  Kramer M, Mele F, Jovic S, Fernandez BM, Jarrossay D, Low JS, Sokollik C, Filipowicz Sinnreich M, Ferrari-Lacraz S, Mieli-Vergani G, Vergani D, Lanzavecchia A, Cassotta A, Terziroli Beretta-Piccoli B, Sallusto F.
  J Clin Invest. 2025 Jan 16;135(2):e183776.
• Unmet needs in autoimmune liver diseases
  Kolev M, Kremer AE, Sokollik C, Gershwin ME, Terziroli Beretta-Piccoli B; speakers of 4th Swiss Autoimmune Liver Disease Meeting.
  Curr Opin Immunol. 2025 Aug;95:102565.
• Engineered monoclonal antibody tobevibart enhances HBsAg capture by Fc receptor-positive cells and activates HBV-specific T cells.
  Vincenzetti L, Wong R, Marzi R, Guarino B, Stefanutti E, Gupta SV, Rosen LE, Belnap DM, Wang L, Chen YP, di Iulio J, Momin A, Tracy KE, Deshpande S, Errico JM, Giovannoni F, Sprugasci N, Peter A, Seu L, Cloutier D, Tay CH, Snell G, Czudnochowski N, Lempp FA, Havenar-Daughton C, Benigni F, Lanzavecchia A, Agarwal K, Yuen MF, Wedemeyer H, Gane E, Arvin A, Corti D, Schmid MA.
  J Hepatol. 2025 Aug 27:S0168-8278(25)02452-3.
• Intrathecal monovalent fragments from two human monoclonal antibodies block tetanus neurotoxin in rodents.
  Fabris F, Meglić P, Šoštarić P, Corti D, Lanzavecchia A, Grinzato A, Rossetto O, Matak I, Pirazzini M.
  iScience. 2025 Aug 22;28(9):113422.
• Translon: a single term for translated regions.
  Świrski MI, […], Biffo S, et al.
  Nat Methods. 2025 Oct;22(10):2002-2006.
• The many ways to inhibit translation by Sorafenib in liver cancer cells.
  Contreras L, Ricciardi S, Biffo S, Muntané J, de la Cruz J.
  Mol Cell Biochem. 2025 Sep 15.
• Chromatin remodeling restrains oncogenic functions in prostate cancer.
  Rosti V, Lembo G, Petrini C, Gorini F, Quadri R, Cordiglieri C, Mutarelli M, Salviato E, Casari E, Di Patrizio Soldateschi E, Montanari E, Albo G, Ripa F, Fasciani A, Crosti M, De Lorenzis E, Maggioni M, Vaira V, Vivo M, Ferrari F, Lanzuolo C.
  Nat Commun. 2025 Oct 16;16(1):9174.

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